Explanipedia

Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys Open

Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec , et al. · 2025

Caloric restriction (CR) is a dietary intervention that delays the onset of age‐related diseases and enhances survival in diverse organisms, and although changes in adipose tissues have been implicated in the beneficial effects of CR, the …

The draft genome of the Wisconsin Miniature SwineTM, a valuable biomedical research tool Open

Alex Veith, Jennifer J. Meudt, Jamie L. Reichert, Jennifer M. Frank, Derek M. Pavelec , et al. · 2025

Porcine biomedical models have emerged as valuable tools in biomedical research due to their physiological, anatomical, metabolic, immunological, and genetic similarities to humans. As a result, they offer greater relevance for translation…

Caloric restriction reprograms adipose tissues in rhesus monkeys Open

Josef P. Clark, Timothy W. Rhoads, Sean J. McIlwain, Michael A. Polewski, Derek M. Pavelec , et al. · 2025

Caloric restriction (CR) is a dietary intervention that delays the onset of age-related diseases and enhances survival in diverse organisms, and although changes in adipose tissues have been implicated in the beneficial effects of CR the m…

P194: Advancing diagnostic precision in rare genetic disorders: Insights from the University of Wisconsin Undiagnosed Disease Program Open

Bryn D. Webb, Jadin Heilmann, April Hall, Kim M. Keppler‐Noreuil, Derek M. Pavelec , et al. · 2025

Impact of acid blocker therapy on growth, gut microbiome, and lung disease in young children with cystic fibrosis Open

Xiaoyue Cathy Liu, Taiya R. Bach, Philip M. Farrell, Derek M. Pavelec, Nicholas Antos , et al. · 2024

Objective Acid blocker therapy (ABT) has become common in cystic fibrosis (CF), despite insufficient evidence for benefits and studies showing potentially negative effects. We examined associations between ABT usage and growth, gut microbi…

Single-cell RNA sequencing of neurofibromas reveals a tumor microenvironment favorable for neural regeneration and immune suppression in a neurofibromatosis type 1 porcine model Open

Dalton McLean, Jennifer J. Meudt, Loren D. Lopez Rivera, Dominic T. Schomberg, Derek M. Pavelec , et al. · 2023

Neurofibromatosis Type 1 (NF1) is one of the most common genetically inherited disorders that affects 1 in 3000 children annually. Clinical manifestations vary widely but nearly always include the development of cutaneous, plexiform and di…

Chronic jetlag accelerates pancreatic neoplasia in conditional Kras -mutant mice Open

Patrick B. Schwartz, Morgan T. Walcheck, Manabu Nukaya, Derek M. Pavelec, Kristina A. Matkowskyj , et al. · 2023

Misalignment of the circadian clock compared to environmental cues causes circadian desynchrony, which is pervasive in humans. Clock misalignment can lead to various pathologies including obesity and diabetes, both of which are associated …

Whole genome sequencing of CCR5 CRISPR-Cas9-edited Mauritian cynomolgus macaque blastomeres reveals large-scale deletions and off-target edits Open

Jenna Kropp Schmidt, Yun Hee Kim, Nick Strelchenko, Sarah R. Gierczic, Derek M. Pavelec , et al. · 2023

Introduction: Genome editing by CRISPR-Cas9 approaches offers promise for introducing or correcting disease-associated mutations for research and clinical applications. Nonhuman primates are physiologically closer to humans than other labo…

Chronic jetlag accelerates pancreatic neoplasia in conditional Kras-mutant mice Open

Patrick B. Schwartz, Morgan T. Walcheck, Manabu Nukaya, Derek M. Pavelec, Kristina A. Matkowskyj , et al. · 2023

Misalignment of the circadian clock compared to environmental cues causes circadian desynchrony, which is pervasive in humans. Clock misalignment can lead to various pathologies including obesity and diabetes, both of which are associated …

Chronic Jetlag Accelerates Pancreatic Neoplasia in ConditionalKras-Mutant Mice Open

Patrick B. Schwartz, Morgan T. Walcheck, Manabu Nukaya, Derek M. Pavelec, Kristina A. Matkowskyj , et al. · 2022

Misalignment of the circadian clock compared to environmental cues causes circadian desynchrony, which is pervasive in humans. Clock misalignment can lead to various pathologies including obesity and diabetes, both of which are associated …

PC3. IDENTIFICATION OF GENETIC VARIANTS IN PARRY ROMBERG DISEASE USING WHOLE EXOME SEQUENCING Open

Sarah Lyon, Jacqueline S. Israel, Rebecca Farmer, Mark E. Berres, Derek M. Pavelec , et al. · 2022

PURPOSE: The causative genetic changes underlying hemifacial atrophy (Parry Romberg disease) have yet to be identified. The purpose of this study was to investigate critical genetic loci that may cause phenotypic changes observed in this p…

A protocol for locating and counting transgenic sequences from laboratory animals using a map-then-capture (MapCap) sequencing workflow: procedure and application of results Open

Sidney S. Dicke, C. Dustin Rubinstein, James M. Speers, Mark E. Berres, Derek M. Pavelec , et al. · 2022

Transgenic rodent models for human diseases have been widely used over the past 50 years and are a mainstay of many biomedical research programs. Oftentimes the sequence of the transgenic segment of DNA is carefully designed but incorporat…

Milan Interobserver Reproducibility Study (MIRST): Milan System 2018 Open

Daniel Kurtycz, E Rossi, Zubair Baloch, Derek M. Pavelec, Emilio Madrigal , et al. · 2020

PGC‐1a integrates a metabolism and growth network linked to caloric restriction Open

Karl N. Miller, Josef P. Clark, Stephen A. Martin, Porsha R. Howell, Maggie S. Burhans , et al. · 2019

Deleterious changes in energy metabolism have been linked to aging and disease vulnerability, while activation of mitochondrial pathways has been linked to delayed aging by caloric restriction (CR). The basis for these associations is poor…

Schwann cell transcript biomarkers for hereditary neuropathy skin biopsies Open

John Svaren, John J. Moran, Xingyao Wu, Riccardo Zuccarino, Chelsea Bacon , et al. · 2019

Objective Charcot‐Marie‐Tooth (CMT) disease is most commonly caused by duplication of a chromosomal segment surrounding Peripheral Myelin Protein 22 , or PMP22 gene, which is classified as CMT1A. Several candidate therapies reduce Pmp22 mR…

Carrier frequency estimation of Zellweger spectrum disorder using ExAC database and bioinformatics tools Open

Eva Vasiljevic, Zhan Ye, Derek M. Pavelec, Burcu F. Darst, Corinne D. Engelman , et al. · 2019

The Integrative Conjugative Element clc (ICEclc) of Pseudomonas aeruginosa JB2 Open

C. Chioma, Shivangi Vayla, Vidya de Gannes, Mark E. Berres, Jason Walker , et al. · 2018

Integrative conjugative elements (ICE) are a diverse group of chromosomally integrated, self-transmissible mobile genetic elements (MGE) that are active in shaping the functions of bacteria and bacterial communities. Each type of ICE carri…

Caloric Restriction Engages Hepatic RNA Processing Mechanisms in Rhesus Monkeys Open

Timothy W. Rhoads, Maggie S. Burhans, Vincent B. Chen, Paul D. Hutchins, Matthew J. P. Rush , et al. · 2018

Molecular profiles of the hepatic response to caloric restriction in rhesus monkeys Open

Tim Rhoads, Maggie S. Burhans, Vincent Chen, Paul D. Hutchins, Matthew J. P. Rush , et al. · 2018

This dataset contains data derived from liver biopsy tissue collected at two time points from young adult rhesus macaques (Macaca mulatta). The animals were an all-male subset of a larger study begun at the University of Wisconsin-Madison …

Exome Sequence Analysis of 14 Families With High Myopia Open

Bethany A. Kloss, Stuart W. Tompson, Kristina N. Whisenhunt, Krystina Quow, Samuel J. Huang , et al. · 2017

Whole exome sequencing was performed to determine gene variants implicated in the pathogenesis of AD high myopia. This study provides new genes for consideration in the pathogenesis of high myopia, and may aid in the development of genetic…

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