Explanipedia

184 Experience of Hypothermic Oxygenated Machine Perfusion for Liver Transplantation and Ex-vivo Liver Resection-largest reported single centre experience in the UK Open

Rodrigo Figueiredo, Bhargava Chikkala, Abdullah Malik, Samuel J Tingle, Emily Thompson , et al. · 2025

Background Hypothermic oxygenated machine perfusion (HOPE) is being increasingly utilised in deceased donor liver transplantation to recondition expanded-criteria livers prior to transplantation as well as reducing night time liver transpl…

168 Pancreas transplant outcomes after allocation though the NHSBT pancreas fast-track scheme (FTS) Open

Ruth Owen, Lewis Simmonds, Emily Thompson, Samuel J Tingle, Chris Callaghan , et al. · 2025

Background The fast-track pancreas scheme (FTS) was brought in to improve pancreas utilisation. It created a scheme for the allocation of pancreas grafts not yet allocated at the time retrieval commenced. There are no previous reports of p…

80 Selective internal radiotherapy (SIRT) versus Hepatic artery embolization (HAE) for the treatment of neuroendocrine liver metastases Open

Connor Lynch, Samuel J Tingle, Georgios Kourounis, Rodrigo Figueiredo, Jeremy French , et al. · 2025

Introduction Liver-directed therapies are an important component of palliative control of disease burden and carcinoid syndrome for unresectable liver metastases of neuroendocrine tumours. Hepatic artery embolization (HAE) and selective in…

Heart Transplantation and Donation After Circulatory Death in Children. A Review of the Technological, Logistical and Ethical Framework Open

Louise Kenny, Liz Armstrong, Marius Berman, Joe Brierley, David Crossland , et al. · 2025

Heart transplant for adults following Donation after Circulatory Death (DCD) is well established in many parts of the world, including the United Kingdom (UK). Small child DCD hearts have now been recovered in the UK and internationally ut…

Guidelines Development Group for the British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma Open

Shahid A. Khan, Simon Rushbrook, Timothy J. Kendall, Yoh Zen, Raneem Albazaz , et al. · 2024

Severe Cholestasis Predicts Recurrent Primary Sclerosing Cholangitis Following Liver Transplantation Open

Bishoi Aziz, Beverley Kok, Matthew Cheah, Ellina Lytvyak, Carlos Moctezuma‐Velázquez , et al. · 2024

INTRODUCTION: Primary sclerosing cholangitis (PSC) may reoccur following liver transplantation (LT), and the diagnosis established once imaging studies demonstrate the diagnostic cholangiographic appearance. To evaluate whether the develop…

Does Time to Asystole in Donors After Circulatory Death Impact Recipient Outcome in Liver Transplantation? Open

Abdullah Malik, Samuel J Tingle, Chris Varghese, Ruth Owen, Balaji Mahendran , et al. · 2024

Background. The agonal phase can vary following treatment withdrawal in donor after circulatory death (DCD). There is little evidence to support when procurement teams should stand down in relation to donor time to death (TTD). We assessed…

The impact of time to death in donors after circulatory death on recipient outcome in simultaneous pancreas-kidney transplantation Open

Abdullah Malik, Samuel J Tingle, Nicholas Chung, Ruth Owen, Balaji Mahendran , et al. · 2024

Multi-Centre UK Analysis of Simultaneous Pancreas and Kidney (SPK) Transplant in Recipients With Type 2 Diabetes Mellitus Open

Ruth Owen, Harry Carr, Claire Counter, Samuel J Tingle, Emily Thompson , et al. · 2024

90% of the UK diabetic population are classified as T2DM. This study aims to compare outcomes after SPK transplant between recipients with T1DM or T2DM. Data on all UK SPK transplants from 2003–2019 were obtained from the NHSBT Registry ( …

Racial disparities in outcomes after liver transplantation in the UK: registry analysis Open

Balaji Mahendran, Samuel J Tingle, Abdullah Malik, Rodrigo Figueiredo, John Hammond , et al. · 2024

British Society of Gastroenterology guidelines for the diagnosis and management of cholangiocarcinoma Open

Simon Rushbrook, Timothy J. Kendall, Yoh Zen, Raneem Albazaz, Prakash Manoharan , et al. · 2023

These guidelines for the diagnosis and management of cholangiocarcinoma (CCA) were commissioned by the British Society of Gastroenterology liver section. The guideline writing committee included a multidisciplinary team of experts from var…

Impact of Hepatitis E Virus Screening in the UK Deceased Organ Donor Population Open

Ines Ushiro‐Lumb, John Forsythe, Becky Haywood, Christie Geoghegan, Victoria Maddox , et al. · 2023

Universal Hepatitis E Virus (HEV) screening of deceased organ donors was implemented by the UK national organ procurement organisation in October 2017. Donor testing for HEV infection is done post-transplant; detection of HEV ribonucleic a…

International consensus recommendations on face transplantation: A 2-step Delphi study Open

Benedetto Longo, Fay Bound Alberti, Bohdan Pomahač, Julian J. Pribaz, Jean‐Paul Meningaud , et al. · 2023

1221 Recipient Outcomes After Simultaneous Pancreas and Kidney Transplant Delineated by Donor eGFR Open

Ruth Owen, N Fitzpatrick, Claire Counter, Abdullah Malik, Bhuvanesh Mahendran , et al. · 2023

Aim This study aimed to assess if the use of kidneys with a decreased eGFR had an adverse effect on patient and graft survival. Method Data on all UK SPKT’s from 2001-2021 were obtained from the NHSBT UK Transplant Registry (n = 2,631). Ca…

Fibrin-based haemostatic agents for reducing blood loss in adult liver resection Open

Abdullah Malik, Aimen Amer, Samuel J Tingle, Emily Thompson, Steven A. White , et al. · 2023

The evidence for the outcomes in both comparisons (FBHAs versus no intervention and FBHAs versus non-FBHAs) was of very low certainty (or low certainty in one instance) and cannot justify the routine use of FBHAs to reduce blood loss in ad…

Incidental lymphadenopathy in renal transplantation Open

NX Ho, AK Malik, S Moulding, Frederick Farrow, David Talbot , et al. · 2023

There are currently no published guidelines on the management of incidentally enlarged iliac LNs during transplantation. Current literature suggests that clinically significant lymphadenopathy needs to be investigated in all patients. Base…

O041 Recipient outcomes after simultaneous pancreas and kidney transplant delineated by donor EGFR Open

Ruth Owen, N Fitzpatrick, Claire Counter, Abdullah Malik, Bhuvanesh Mahendran , et al. · 2023

Introduction This study aimed to assess if the use of kidneys from donors with a decreased eGFR had an adverse effect on patient and graft survival. Methods Data on all UK SPKT's from 2001-2021 were obtained from the NHSBT UK Transplant Re…

O004 Impact of normothermic regional perfusion on recipient outcomes after simultaneous pancreas and kidney transplantation – a UK analysis from the NHSBT Pancreas Advisory Group Open

Ruth Owen, C Counter, Samuel J Tingle, L. Simmonds, Chris Callaghan , et al. · 2023

Introduction A quarter of UK SPK transplants are from Deceased Cardiac Donors(DCD), with an increasing number recovered following in-situ normothermic regional perfusion(NRP). The aim of this study was to review the UK experience of SPK tr…

O037 VEGF-A: a potential prognostic biomarker for donor liver viability Open

G Cheemungtoo, J. W. Dobbins, Balaji Mahendran, Samuel J Tingle, Lucy Bates , et al. · 2023

Introduction Waitlist mortality for liver transplant recipients may be tackled by increasing graft utilisation from marginal donors. At present, there are no reliable methods of assessing the quality of potential donor grafts prior to post…

Data Supplement from DNA-PK—A Candidate Driver of Hepatocarcinogenesis and Tissue Biomarker That Predicts Response to Treatment and Survival Open