Derek Nye
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View article: Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration
Kinetochore proteins suppress neuronal microtubule dynamics and promote dendrite regeneration Open
Kinetochores are quintessential mitotic structures that monitor microtubule connections to chromosomes. Here, it is shown that kinetochore proteins are required in mature neurons for normal regeneration of injured dendrites. At the subcell…
View article: The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons
The receptor tyrosine kinase Ror is required for dendrite regeneration in Drosophila neurons Open
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model of dendrite regeneration, we performed a candidate screen of r…
View article: Endosomal Wnt signaling proteins control microtubule nucleation in dendrites
Endosomal Wnt signaling proteins control microtubule nucleation in dendrites Open
Dendrite microtubules are polarized with minus-end-out orientation in Drosophila neurons. Nucleation sites concentrate at dendrite branch points, but how they localize is not known. Using Drosophila, we found that canonical Wnt signaling p…
View article: Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw
Degeneration of Injured Axons and Dendrites Requires Restraint of a Protective JNK Signaling Pathway by the Transmembrane Protein Raw Open
The degeneration of injured axons involves a self-destruction pathway whose components and mechanism are not fully understood. Here, we report a new regulator of axonal resilience. The transmembrane protein Raw is cell autonomously require…
View article: Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity
Regulation of mRNA Translation Is a Novel Mechanism for Phthalate Toxicity Open
Phthalates are a group of plasticizers that are widely used in many consumer products and medical devices, thus generating a huge burden to human health. Phthalates have been known to cause a number of developmental and reproductive disord…
View article: Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration
Mitochondria and Caspases Tune Nmnat-Mediated Stabilization to Promote Axon Regeneration Open
Axon injury can lead to several cell survival responses including increased stability and axon regeneration. Using an accessible Drosophila model system, we investigated the regulation of injury responses and their relationship. Axon injur…