Derek Sim
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View article: Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid
Divergent modulation of activated protein C pleiotropic functions by antibodies that differ by a single amino acid Open
Activated protein C (APC) is a pleiotropic plasma protease with diverse functions derived from its anticoagulant, anti-inflammatory, and cytoprotective activities. The selective uncoupling and/or modulation of these APC activities by antib…
View article: Peptide nucleic acid–dependent artifact can lead to false-positive triplex gene editing signals
Peptide nucleic acid–dependent artifact can lead to false-positive triplex gene editing signals Open
Significance Many current gene editing techniques rely on use of a donor template to elicit correction. While functional correction remains the strongest indicator of successful editing, many candidates are initially screened via in vitro–…
View article: In vitro characterization of CT‐001—a short‐acting factor VIIa with enhanced prohemostatic activity
In vitro characterization of CT‐001—a short‐acting factor VIIa with enhanced prohemostatic activity Open
View article: Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia
Targeted inhibition of activated protein C by a non-active-site inhibitory antibody to treat hemophilia Open
View article: Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease
Blockade of placental growth factor reduces vaso-occlusive complications in murine models of sickle cell disease Open
View article: Clot stability as a determinant of effective factor VIII replacement in hemophilia A
Clot stability as a determinant of effective factor VIII replacement in hemophilia A Open
Effective clot formation can be achieved in HemA by replacement therapy, which alters the architecture of the fibrin network and associated cells, thus increasing clot stiffness and decreasing clot permeability.
View article: Dataset for Wale et al. 2017 Proc R Soc B
Dataset for Wale et al. 2017 Proc R Soc B Open
Dataset used in the paper. Includes daily measurements of red blood cell densities and the weight of mouse hosts, as well as the density of each parasite strain. Information about units of measurements given in the sheet entitled 'Notes on…