Explanipedia

Acute and Long-Term Healthcare Utilization and Expenditures for Serious Bacterial Infections among Newborns in US Hospitals Open

Kristen N. Noble, Katharina Schley, Jennifer C. Moïsi, Derek Weycker · 2025

Serious bacterial infections among newborns place a substantial burden on the US healthcare system for the treatment of acute illness as well as long-term complications. Interventions targeting the prevention of newborn bacterial infection…

Diagnostic Journey and Health Care Burden of Patients With Creutzfeldt-Jakob Disease in the United States Open

Emily Kutrieb, Montserrat Vera Llonch, Derek Weycker, Steven Kymes, Duncan Brown , et al. · 2025

[This corrects the article DOI: 10.1212/CPJ.0000000000200502.].

Rates of acute pancreatitis and cardiovascular events among adults with severe or extreme hypertriglyceridemia in US clinical practice Open

Asia Sikora Kessler, Seth J. Baum, Emily Kutrieb, Montserrat Vera Llonch, Alexander Lonshteyn , et al. · 2025

Background Severe and extreme hypertriglyceridemia (sHTG [TG 500–879 mg/dL; 5.65–9.93 mmol/L]; eHTG [TG ≥ 880 mg/dL; ≥ 9.94 mmol/L]) are important risk factors for acute pancreatitis (AP) and cardiovascular (CV) events. The objective of th…

Disparities in invasive pneumococcal disease, pneumonia, and otitis media among US children by comorbidity profile and insurance status Open

Rotem Lapidot, Ahuva Averin, Derek Weycker, Liping Huang, Jeffrey Vietri , et al. · 2025

Background Near-universal pediatric use of pneumococcal conjugate vaccines in the United States (US) has yielded substantive reductions childhood invasive pneumococcal disease (IPD), pneumonia (PNE), and otitis media (OM), especially among…

Uptake of Pneumococcal Vaccines Among U.S. Adults After 2022 Update to Recommendations Open

Ahuva Averin, Jeffrey Vietri, Adriano Arguedas Mohs, Sarah J. Willis, Alexander Lonshteyn , et al. · 2025

Diagnostic Journey and Health Care Burden of Patients With Creutzfeldt-Jakob Disease in the United States Open

Emily Kutrieb, Montserrat Vera Llonch, Derek Weycker, Steven Kymes, Duncan Brown , et al. · 2025

Study findings suggest that, in US clinical practice, patients with CJD present with one or more clinical symptoms affecting motor, cognitive, or other domains, and many alternative diagnoses are considered, which may prolong the diagnosti…

Cost-effectiveness of bivalent respiratory syncytial virus Prefusion F (RSVpreF) maternal vaccine among infants in the United States Open

Ahuva Averin, Erin Quinn, Mark Atwood, Derek Weycker, Kimberly M. Shea , et al. · 2025

Maternal vaccination with RSVpreF would substantially reduce the clinical and economic burden of RSV in infants, resulting in a cost-effectiveness ratio of $89,733 per QALY if administered year-round or cost savings if administered seasona…

Potential public health and economic impact of maternal vaccination with bivalent respiratory syncytial virus prefusion F (RSVpreF) vaccine for the prevention of acute respiratory infection among infants in the United States Open

Ahuva Averin, Amy Law, Derek Weycker, Mark Atwood, Erin Quinn , et al. · 2025

Even with limited uptake and without considering benefits to pregnant persons or reductions in RSV-related sequelae, maternal vaccination with RSVpreF would substantially reduce the public health and economic burden of RSV-ARI in US infant…

Cost of invasive pneumococcal disease, all-cause pneumonia, and all-cause otitis media among commercial-insured US children Open

Ahuva Averin, Derek Weycker, Rotem Lapidot, Mark H. Rozenbaum, Liping Huang , et al. · 2025

Costs of IPD, all-cause PNE, and all-cause OM are high, particularly in the hospital setting. All-cause PNE, one of the most common causes of hospitalization for children, is particularly costly for children with comorbidities.

Short-term and Long-term Mortality Following Hospitalized and Ambulatory Lower Respiratory Tract Illnesses Among US Adults Open

Ahuva Averin, Reiko Sato, Elizabeth Begier, Kari Yacisin, Linnea Houde , et al. · 2025

Background Lower respiratory tract illness (LRTI) is a significant cause of morbidity among adults, particularly older adults and adults with underlying medical conditions. Evidence on short- and long-term risks of mortality among adults r…

Real-World Evaluation of Treatment Patterns, Healthcare Costs, and Healthcare Resource Utilization Among Patients with Non-small Cell Lung Cancer in the US Receiving Sotorasib Open

Ihtisham Sultan, David Waterhouse, Divyan Chopra, Alexander Lonshteyn, Derek Weycker , et al. · 2024

Cost-Effectiveness of Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Vaccine During Pregnancy for Prevention of Respiratory Syncytial Virus Among Infants in Argentina Open

Lucila Rey‐Ares, Ahuva Averin, Nadia Zuccarino, Celina G. Vega, Emily Kutrieb , et al. · 2024

RSVpreF among pregnant persons would significantly reduce the clinical and economic burden of RSV-LRTI among infants in Argentina and would be considered a cost-effective intervention up to a price of approximately $75.

Modified blood cell GAP model as a prognostic biomarker in idiopathic pulmonary fibrosis Open

Michael Kreuter, Joyce Lee, Argyrios Tzouvelekis, Justin M. Oldham, Philip L. Molyneaux , et al. · 2024

Background The Gender, Age and Physiology (GAP) model is a simple mortality prediction tool in patients with idiopathic pulmonary fibrosis that uses demographic and physiological variables available at initial evaluation. White blood cell …

Cost-Effectiveness of 20-Valent Pneumococcal Conjugate Vaccine Among US Children with Underlying Medical Conditions Open

Mark H. Rozenbaum, Erica Chilson, Raymond Farkouh, Liping Huang, Alejandro Cané , et al. · 2024

Use of PCV20 among young children with CMC+ and IC in the USA would reduce the clinical burden of pneumococcal disease and yield overall cost savings from both the US healthcare system and societal perspectives. Higher PCV20 uptake could f…

Attributable Cost of Adult Respiratory Syncytial Virus Illness Beyond the Acute Phase Open

Ahuva Averin, Mark Atwood, Reiko Sato, Kari Yacisin, Elizabeth Begier , et al. · 2024

Background Estimates of the cost of medically attended lower respiratory tract illness (LRTI) due to respiratory syncytial virus (RSV) in adults, especially beyond the acute phase, is limited. This study was undertaken to estimate the attr…

A formula for predicting emphysema extent in combined idiopathic pulmonary fibrosis and emphysema Open

Athol U. Wells, Joseph Jacob, Nicola Sverzellati, Gary Cross, Joseph Barnett , et al. · 2024

Background No single pulmonary function test captures the functional effect of emphysema in idiopathic pulmonary fibrosis (IPF). Without experienced radiologists, other methods are needed to determine emphysema extent. Here, we report the …

Rates of Lower Respiratory Tract Illness in US Adults by Age and Comorbidity Profile Open

Derek Weycker, Ahuva Averin, Linnea Houde, Kevin Ottino, Kimberly M. Shea , et al. · 2024

Incidence of LRTI, including that due to RSV, especially for events requiring acute inpatient care, is markedly higher among older adults and adults of all ages with CMC or IC.

Lymphoscintigraphy is frequently recommended but seldom used in a “real world setting” Open

Tina Moon, Thomas F. O’Donnell, Derek Weycker, Mark D. Iafrati · 2023

OP78 Cost-effectiveness Of A 20-valent Pneumococcal Conjugate Vaccine To Directly Protect Adults Against Pneumococcal Disease In England Open

Diana Mendes, Ahuva Averin, Mark Atwood, Reiko Sato, Andrew Vyse , et al. · 2023

Introduction Adult vaccination with 13-valent pneumococcal conjugate vaccine is currently recommended in the UK only for very high-risk individuals, with 23-valent pneumococcal polysaccharide vaccine (PPV23) being recommended to all adults…

1942. Potential Public Health Impact of Bivalent Respiratory Syncytial Virus Prefusion F (RSVpreF) Maternal Vaccine for Prevention of RSV among US Infants Open

Ahuva Hanau, Kimberly M. Shea, Derek Weycker, Mark Atwood, Erin Quinn , et al. · 2023

Background Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract illness (LRTI) among young children. A bivalent stabilized prefusion F subunit vaccine (RSVpreF) for pregnant people to protect their infants agains…

The critical role of phlebolymphedema in cellulitis associated with lymphedema: Its incidence and economic impact in a large real-world population Open

Alexandra Tedesco, Thomas O’Donnell, Derek Weycker, Payam Salehi · 2023

The incidence of cellulitis associated with LED varies by the etiology of LED. PLED has the highest rates of both an initial cellulitis episode and recurrent cellulitis events. Additionally, PLED has one of the largest cellulitis-related t…

Impact of Elexacaftor/Tezacaftor/Ivacaftor on Healthcare Resource Utilization and Associated Costs Among People With Cystic Fibrosis in the US: A Retrospective Claims Analysis Open

Michael S. Schechter, Natalia Sabater-Anaya, Gerry Oster, Derek Weycker, Hongsheng Wu , et al. · 2023

FRI090 Patterns Of Triglyceride Testing And Results Over Time Among Patients With Diabetes And Severe Hypertriglyceridemia In US Clinical Practice Open

Emily Kutrieb, Seth J. Baum, Ellen Dukes, Asia Sikora Kessler, Derek Weycker , et al. · 2023

Disclosure: E. Kutrieb: Consulting Fee; Self; Ionis Pharmaceuticals Inc. S.J. Baum: Advisory Board Member; Self; Altimmune, Amgen Inc, Axcella, Boehringer Ingelheim, Eli Lilly & Company, Esperion, Madrigal Pharmaceuticals, Novartis Pharmac…

Pneumococcal vaccine uptake among Medicare Beneficiaries aged ≥65 years following the shared clinical decision-making recommendation for 13-valent pneumococcal conjugate vaccine in 2019 Open

Jeffrey Vietri, Reiko Sato, Ahuva Averin, Derek Weycker, Mahesh Kumar , et al. · 2023

PCV13 use decreased among immunocompetent and immunocompromised persons alike, despite continued routine PCV13 recommendation for the latter group.

Correction to: Under recognition and treatment of lymphedema in head and neck cancer survivors – a database study Open

Michael D. Stubblefield, Derek Weycker · 2023

Under recognition and treatment of lymphedema in head and neck cancer survivors – a database study Open

Michael D. Stubblefield, Derek Weycker · 2023

Purpose Head and neck cancer (HNC) will be diagnosed in approximately 54,000 Americans in 2022 with more than 11,000 dying as a result. The treatment of HNC often involves aggressive multimodal therapy including surgery, radiotherapy, and …

Hemoglobin and End-Organ Damage in Individuals with Sickle Cell Disease Open

William B. Ershler, Laura M. De Castro, Zahra Pakbaz, Aaron Moynahan, Derek Weycker , et al. · 2023

2207. Rates of Lower Respiratory Tract Infections Among US Adults Aged ≥18 Years With and Without Chronic Medical Conditions Open

Derek Weycker, Ahuva Averin, Linnea Houde, Kevin Ottino, Kimberly M. Shea , et al. · 2022

Background While it is widely recognized that older adults and adults with chronic medical conditions are at increased risk of lower respiratory tract infections (LRTI), available evidence on the magnitude of increased risk is limited. Met…

Clinical Impact of Severe Obesity in Patients with Lymphoedema Open

Nicos Labropoulos, Ashna Raiker, Antonios Gasparis, Derek Weycker, Thomas O’Donnell · 2022

There was an increase in SO associated lymphoedema. Patients with lymphoedema SO+ have over a two and half fold increase in cellulitis incidence, with a significant increase in medical resource use and cost. Despite this, patients with lym…

Under Recognition and Treatment of Lymphedema in Head and Neck Cancer Survivors – A Database Study Open

Michael D. Stubblefield, Derek Weycker · 2022

Purpose: Head and neck cancer (HNC) will be diagnosed in approximately 54,000 Americans in 2022 with more than 11,000 dying as a result. The treatment of HNC often involves aggressive multimodal therapy including surgery, radiotherapy, and…

Derek Weycker YOU? Author Swipe