Derek Yecies
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View article: Motion Detection and Correction for Frame-Based Stereotactic Localization
Motion Detection and Correction for Frame-Based Stereotactic Localization Open
View article: IMG-02. Improved prediction of postoperative paediatric cerebellar mutism syndrome using an artificial neural network
IMG-02. Improved prediction of postoperative paediatric cerebellar mutism syndrome using an artificial neural network Open
BACKGROUND: Postoperative paediatric cerebellar mutism syndrome (pCMS) is a common but severe complication which may arise following the resection of posterior fossa tumours in children. Two previous studies have aimed to preoperatively pr…
View article: Improved prediction of postoperative pediatric cerebellar mutism syndrome using an artificial neural network
Improved prediction of postoperative pediatric cerebellar mutism syndrome using an artificial neural network Open
Background Postoperative pediatric cerebellar mutism syndrome (pCMS) is a common but severe complication that may arise following the resection of posterior fossa tumors in children. Two previous studies have aimed to preoperatively predic…
View article: Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome
Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome Open
Cerebellar mutism syndrome, characterised by mutism, emotional lability and cerebellar motor signs, occurs in up to 39% of children following resection of medulloblastoma, the most common malignant posterior fossa tumour of childhood. Its …
View article: Rapid intraoperative diagnosis of pediatric brain tumors using Raman spectroscopy: A machine learning approach
Rapid intraoperative diagnosis of pediatric brain tumors using Raman spectroscopy: A machine learning approach Open
Background Surgical resection is a mainstay in the treatment of pediatric brain tumors to achieve tissue diagnosis and tumor debulking. While maximal safe resection of tumors is desired, it can be challenging to differentiate normal brain …
View article: Radiomic signatures of posterior fossa ependymoma: Molecular subgroups and risk profiles
Radiomic signatures of posterior fossa ependymoma: Molecular subgroups and risk profiles Open
Background The risk profile for posterior fossa ependymoma (EP) depends on surgical and molecular status [Group A (PFA) versus Group B (PFB)]. While subtotal tumor resection is known to confer worse prognosis, MRI-based EP risk-profiling i…
View article: Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome
Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome Open
Aims Cerebellar mutism syndrome occurs in 25% of children following resection of posterior fossa tumours. Characterised by mutism, emotional lability and cerebellar motor signs, the syndrome is usually reversible over weeks to months. Its …
View article: Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome
Spatiotemporal changes in along-tract profilometry of cerebellar peduncles in cerebellar mutism syndrome Open
Cerebellar mutism syndrome, characterised by mutism, emotional lability and cerebellar motor signs, occurs in up to 39% of children following resection of medulloblastoma, the most common malignant posterior fossa tumour of childhood. Its …
View article: Machine Assist for Pediatric Posterior Fossa Tumor Diagnosis: A Multinational Study
Machine Assist for Pediatric Posterior Fossa Tumor Diagnosis: A Multinational Study Open
BACKGROUND Clinicians and machine classifiers reliably diagnose pilocytic astrocytoma (PA) on magnetic resonance imaging (MRI) but less accurately distinguish medulloblastoma (MB) from ependymoma (EP). One strategy is to first rule out the…
View article: IMG-13. MRI-BASED RADIOMICS PROGNOSTIC MARKERS OF POSTERIOR FOSSA EPENDYMOMA
IMG-13. MRI-BASED RADIOMICS PROGNOSTIC MARKERS OF POSTERIOR FOSSA EPENDYMOMA Open
PURPOSE Posterior fossa ependymomas (PFE) are common pediatric brain tumors often assessed with MRI before surgery. Advanced radiomic analysis show promise in stratifying risk and outcome in other pediatric brain tumors. Here, we extracted…
View article: The landscape of somatic copy-number alteration across human cancers
The landscape of somatic copy-number alteration across human cancers Open
A powerful way to discover key genes playing causal roles in oncogenesis is to identify genomic regions that undergo frequent alteration in human cancers. Here, we report high-resolution analyses of somatic copy-number alterations (SCNAs) …
View article: Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors
Locoregionally administered B7-H3-targeted CAR T cells for treatment of atypical teratoid/rhabdoid tumors Open
Atypical teratoid/rhabdoid tumors (ATRTs) typically arise in the central nervous system (CNS) of children under 3 years of age. Despite intensive multimodal therapy (surgery, chemotherapy and, if age permits, radiotherapy), median survival…
View article: Difference-Frequency Ultrasound Imaging With Non-Linear Contrast
Difference-Frequency Ultrasound Imaging With Non-Linear Contrast Open
Conventional ultrasound imaging is based on the scattering of sound from inhomogeneities in the density and the speed of sound and is often used in medicine to resolve pathologic compared to normal tissue. Here we demonstrate a difference-…
View article: Stereotactic laser ablation for completion corpus callosotomy
Stereotactic laser ablation for completion corpus callosotomy Open
OBJECTIVE Completion corpus callosotomy can offer further remission from disabling seizures when a prior partial corpus callosotomy has failed and residual callosal tissue is identified on imaging. Traditional microsurgical approaches to s…
View article: Molecular correlates of cerebellar mutism syndrome in medulloblastoma
Molecular correlates of cerebellar mutism syndrome in medulloblastoma Open
Background Cerebellar mutism syndrome (CMS) is a common complication following resection of posterior fossa tumors, most commonly after surgery for medulloblastoma. Medulloblastoma subgroups have historically been treated as a single entit…
View article: Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging
Speckle modulation enables high-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging Open
View article: Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells <i>in Vivo</i> through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation
Spatiotemporal Tracking of Brain-Tumor-Associated Myeloid Cells <i>in Vivo</i> through Optical Coherence Tomography with Plasmonic Labeling and Speckle Modulation Open
By their nature, tumors pose a set of profound challenges to the immune system with respect to cellular recognition and response coordination. Recent research indicates that leukocyte subpopulations, especially tumor-associated macrophages…
View article: RADI-03. ASL PERFUSION IMAGING OF THE FRONTAL LOBES PREDICTS THE OCCURRENCE AND RESOLUTION OF POSTERIOR FOSSA SYNDROME
RADI-03. ASL PERFUSION IMAGING OF THE FRONTAL LOBES PREDICTS THE OCCURRENCE AND RESOLUTION OF POSTERIOR FOSSA SYNDROME Open
INTRODUCTION: Posterior fossa syndrome (PFS) is a common complication following the resection of posterior fossa tumors in children. The pathophysiology of PFS remains incompletely elucidated, however the wide-ranging symptoms of PFS sugge…
View article: Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near Infrared Window for Enhanced Angiography in Live Animals
Gold Nanoprisms as Optical Coherence Tomography Contrast Agents in the Second Near Infrared Window for Enhanced Angiography in Live Animals Open
Optical coherence tomography angiography (OCTA) is an important tool for investigating vascular networks and microcirculation in living tissue. Traditional OCTA detects blood vessels via intravascular dynamic scattering signals derived fro…
View article: High-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging
High-resolution wide-field human brain tumor margin detection and in vivo murine neuroimaging Open
Current in vivo neuroimaging techniques provide limited field of view or spatial resolution and often require exogenous contrast. These limitations prohibit detailed structural imaging across wide fields of view and hinder intraoperative t…
View article: Wide-field dynamic monitoring of immune cell trafficking in murine models of glioblastoma
Wide-field dynamic monitoring of immune cell trafficking in murine models of glioblastoma Open
Leukocyte populations, especially tumor-associated macrophages (TAMs), are capable of mediating both anti- and pro-tumor processes and play significant roles in the tumor microenvironment. Moreover, TAMs have been shown to exert substantia…
View article: Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children
Long-term outcomes of primarily metastatic juvenile pilocytic astrocytoma in children Open
OBJECTIVE Primarily metastatic juvenile pilocytic astrocytoma (JPA) is rare, likely representing 2%–3% of all cases of JPA. Due to the rarity of primarily metastatic JPA, there is currently no standard treatment paradigm and the long-term …
View article: Near-Fatal Gastrointestinal Hemorrhage in a Child with Medulloblastoma on High Dose Dexamethasone
Near-Fatal Gastrointestinal Hemorrhage in a Child with Medulloblastoma on High Dose Dexamethasone
Open
A four-year-old female was admitted to a university-based children's hospital with a newly-diagnosed posterior fossa tumor. She was started on famotidine and high-dose dexamethasone and underwent gross total resection of a medulloblastoma.…
View article: Giant Prolactinoma Presenting with Neck Pain and Structural Compromise of the Occipital Condyles
Giant Prolactinoma Presenting with Neck Pain and Structural Compromise of the Occipital Condyles Open
Prolactinomas are the most common form of endocrinologically active pituitary adenoma; they account for ∼ 45% of pituitary adenomas encountered in clinical practice. Giant adenomas are those > 4 cm in diameter. Less than 0.5% of pituitary …