Derrick Callahan
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View article: STAT3 Ser727 phosphorylation is required for regulating the balance of plasma cell differentiation and germinal center B cell proliferation via optimizing STAT3-mediated transcription 2790
STAT3 Ser727 phosphorylation is required for regulating the balance of plasma cell differentiation and germinal center B cell proliferation via optimizing STAT3-mediated transcription 2790 Open
Description IL-21R, which signals via STAT3, is critical for normal germinal center (GC) responses. Though IL-21 promotes STAT3 phosphorylation at Tyr705, STAT3 is also phosphorylated at Ser727, a conserved site across STAT proteins and sp…
View article: Epigenetic priming in memory B cells versus naive B cells results in differential induction genes related to T-B interactions 3391
Epigenetic priming in memory B cells versus naive B cells results in differential induction genes related to T-B interactions 3391 Open
Description Naïve B cells (NBCs) and memory B cell (MBC) subsets can be distinguished by unique epigenetic states, which often results in meaningful gene expression in the resting cells. However, these cells also differ in genes that are r…
View article: BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4
BLIMP1 controls GC B cell expansion and exit through regulating cell cycle progression and key transcription factors BCL6 and IRF4 Open
In B cells, BLIMP1 is required for plasma cell differentiation. BLIMP1 is also expressed in some germinal center (GC) B cells (GCBC), yet the role of BLIMP1 in GCBC is not understood. Here we generated mixed bone marrow (BM) chimeric mice …
View article: 804 Genetic dissection of TLR9 reveals complex regulatory and cryptic pro-inflammatory roles in murine lupus
804 Genetic dissection of TLR9 reveals complex regulatory and cryptic pro-inflammatory roles in murine lupus Open
In lupus, TLR7 and TLR9 mediate loss of tolerance to RNA and DNA, respectively. Yet, TLR7 promotes while TLR9 protects from disease, implying differences in signaling. To dissect this 'TLR paradox', we generated two TLR9 point mutants—lac…
View article: Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states
Memory B cell subsets have divergent developmental origins that are coupled to distinct imprinted epigenetic states Open
View article: IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells
IL-21R signal reprogramming cooperates with CD40 and BCR signals to select and differentiate germinal center B cells Open
Both B cell receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to synergistically induce c-MYC and phosphorylated S6 ribosomal protein (p-S6), markers of positive selection. How interleukin-21 (IL-21), a …
View article: Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus
Genetic dissection of TLR9 reveals complex regulatory and cryptic proinflammatory roles in mouse lupus Open
View article: Surface phenotypes of naive and memory B cells in mouse and human tissues
Surface phenotypes of naive and memory B cells in mouse and human tissues Open
View article: GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation
GPR18 Controls Reconstitution of Mouse Small Intestine Intraepithelial Lymphocytes following Bone Marrow Transplantation Open
Specific G protein coupled receptors (GPRs) regulate the proper positioning, function, and development of immune lineage subsets. Here, we demonstrate that GPR18 regulates the reconstitution of intraepithelial lymphocytes (IELs) of the sma…