Derrick E. Johnson
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View article: Intercept‐AD: Development and qualification of a highly sensitive immunoassay to detect total sabirnetug (ACU193) in human CSF
Intercept‐AD: Development and qualification of a highly sensitive immunoassay to detect total sabirnetug (ACU193) in human CSF Open
Background Sabirnetug (ACU193) is a humanized monoclonal antibody targeting soluble amyloid beta (Aβ) oligomers, which are early contributors to the pathogenesis of Alzheimer’s Disease (AD). An ultrasensitive assay was developed to measure…
View article: Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin
Noncompetitive immunoassay optimized for pharmacokinetic assessments of biologically active efruxifermin Open
Efruxifermin (EFX) is a homodimeric human IgG1 Fc-FGF21 fusion protein undergoing investigation for treatment of liver fibrosis due to nonalcoholic steatohepatitis (NASH), a prevalent and serious metabolic disease for which there is no app…
View article: ODP178 Development and Validation of a Noncompetitive Immunoassay Optimized for the Assessment of Pharmacokinetics of Biologically Active Efruxifermin in Humans
ODP178 Development and Validation of a Noncompetitive Immunoassay Optimized for the Assessment of Pharmacokinetics of Biologically Active Efruxifermin in Humans Open
Efruxifermin (EFX) is a novel fusion biotherapeutic consisting of two modified human fibroblast growth factor (FGF21) variants tethered via short linkers to a hIgG1 Fc domain. EFX is under clinical development by Akero Therapeutics, Inc. f…
View article: Using the Predicted Structure of the Amot Coiled Coil Homology Domain to Understand Lipid Binding
Using the Predicted Structure of the Amot Coiled Coil Homology Domain to Understand Lipid Binding Open
Angiomotins (Amots) are a family of adapter proteins that modulate cellular polarity, differentiation, proliferation, and migration. Amot family members also have a characteristic lipid-binding domain, the coiled coil homology (ACCH) domai…
View article: Activation State-Dependent Substrate Gating in Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II
Activation State-Dependent Substrate Gating in Ca<sup>2+</sup>/Calmodulin-Dependent Protein Kinase II Open
Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly concentrated in the brain where its activation by the Ca 2+ sensor CaM, multivalent structure, and complex autoregulatory features make it an ideal translator of Ca 2+ signa…
View article: Constitutive regulation of the glutamate/aspartate transporter <scp>EAAT</scp>1 by Calcium‐Calmodulin‐Dependent Protein Kinase II
Constitutive regulation of the glutamate/aspartate transporter <span>EAAT</span>1 by Calcium‐Calmodulin‐Dependent Protein Kinase II Open
Glutamate clearance by astrocytes is an essential part of normal excitatory neurotransmission. Failure to adapt or maintain low levels of glutamate in the central nervous system is associated with multiple acute and chronic neurodegenerati…
View article: Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling
Novel Roles for Peroxynitrite in Angiotensin II and CaMKII Signaling Open
Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) oxidation controls excitability and viability. While hydrogen peroxide (H 2 O 2 ) affects Ca 2+ -activated CaMKII in vitro , Angiotensin II (Ang II)-induced CaMKIIδ signaling in cardio…