Desiree A. Marshall
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View article: Supporting the Deceased, Their Families, and Their Communities – Part 2: Practical Guidance for Building an Office of Decedent Affairs
Supporting the Deceased, Their Families, and Their Communities – Part 2: Practical Guidance for Building an Office of Decedent Affairs Open
Context.— After-death care can be complicated and time-consuming for clinical staff, and frustrating for bereaved families. Delays and errors can have damaging legal and reputational consequences for hospitals. Offices of Decedent Affairs …
View article: Supporting the Deceased, Their Families, and Their Communities – Part 1: Why Establish an Office of Decedent Affairs
Supporting the Deceased, Their Families, and Their Communities – Part 1: Why Establish an Office of Decedent Affairs Open
Context.— Decedent Affairs Offices and Programs can serve as an avenue to assist medical centers in facilitating efficient and comprehensive decedent management, despite a paucity of literature on their roles, establishment, and efficacy. …
View article: Challenges in autopsy training for pathology residents: A survey of autopsy directors
Challenges in autopsy training for pathology residents: A survey of autopsy directors Open
View article: Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity.
Immune checkpoint dysregulation in COVID-19 pathogenesis and disease severity. Open
Accumulating evidence suggests dysregulated immune checkpoint (IC) signaling can exacerbate COVID-19 severity, but the role of these molecules in the pathogenesis of fatal COVID-19-related diffuse alveolar damage (DAD) remains elusive. Und…
View article: Organ-specific immunity: A tissue analysis framework for investigating local immune responses to SARS-CoV-2
Organ-specific immunity: A tissue analysis framework for investigating local immune responses to SARS-CoV-2 Open
Local immune activation at mucosal surfaces, mediated by mucosal lymphoid tissues, is vital for effective immune responses against pathogens. While pathogens like severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can spread to m…
View article: Pulmonary Co-Infections Detected Premortem Underestimate Postmortem Findings in a COVID-19 Autopsy Case Series
Pulmonary Co-Infections Detected Premortem Underestimate Postmortem Findings in a COVID-19 Autopsy Case Series Open
Bacterial and fungal co-infections are reported complications of coronavirus disease 2019 (COVID-19) in critically ill patients but may go unrecognized premortem due to diagnostic limitations. We compared the premortem with the postmortem …
View article: Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury
Pontine pathology mediates common symptoms of blast-induced chronic mild traumatic brain injury Open
Understanding how diffuse mild traumatic brain injuries can provoke common and persistent post-concussive symptoms (PCS), such as impaired sleep, is crucial to prevent and treat chronic disability and neurodegeneration. We mapped the spati…
View article: Death Certification: An Interactive Teaching Session
Death Certification: An Interactive Teaching Session Open
Death certification is a key competency for physicians. Our virtual workshop improved participants' skills in completing death certificates. Although a significant number of errors remained after the workshop, most of these residual errors…
View article: Identification of Metastatic Conjunctival Squamous Cell Carcinoma through Neck Palpation
Identification of Metastatic Conjunctival Squamous Cell Carcinoma through Neck Palpation Open
An 80-year-old male with a distant 10 pack-years smoking history and squamous cell carcinoma (SCCA) of the scalp diagnosed 15 years ago presented with a new right nasal bulbar conjunctival lesion found to be invasive SCCA. The patient was …
View article: Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds
Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds Open
Background Activating variants in platelet‐derived growth factor receptor beta (PDGFRB), including a variant we have previously described (p.Tyr562Cys [g.149505130T>C [GRCh37/hg19]; c.1685A>G]), are associated with development of multiorga…
View article: Author Correction: Human neocortical expansion involves glutamatergic neuron diversification
Author Correction: Human neocortical expansion involves glutamatergic neuron diversification Open
View article: Oblivion1: Autopsy Findings of a 31-year-old Man with Sudden Cardiac Arrest, a Case Report of a Sequalae of Kawasaki Disease
Oblivion1: Autopsy Findings of a 31-year-old Man with Sudden Cardiac Arrest, a Case Report of a Sequalae of Kawasaki Disease Open
A 31-year-old man presented to the hospital after suffering a sudden cardiac arrest. Despite optimal therapy, the patient passed away. His medical history included febrile rash at age 2. At autopsy, there was aneurysmal dilation and severe…
View article: Human neocortical expansion involves glutamatergic neuron diversification
Human neocortical expansion involves glutamatergic neuron diversification Open
View article: Altered Mental Status After Esophagogastroduodenoscopy
Altered Mental Status After Esophagogastroduodenoscopy Open
View article: Postmortem Findings Associated With SARS-CoV-2
Postmortem Findings Associated With SARS-CoV-2 Open
Coronavirus Disease 2019 (COVID-19), caused by the novel Severe Acute Respiratory Syndrome–associated Coronavirus 2 (SARS-CoV-2), has become a global threat to public health. COVID-19 is more pathogenic and infectious than the prior 2002 p…
View article: A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Large Multi-institutional Autopsy Survey Study
A Postmortem Portrait of the Coronavirus Disease 2019 (COVID-19) Pandemic: A Large Multi-institutional Autopsy Survey Study Open
Context.— This study represents the largest compilation to date of clinical and postmortem data from decedents with coronavirus disease 2019 (COVID-19). It will augment previously published small series of autopsy case reports, refine clin…
View article: Sensitive Identification of Bacterial DNA in Clinical Specimens by Broad-Range 16S rRNA Gene Enrichment
Sensitive Identification of Bacterial DNA in Clinical Specimens by Broad-Range 16S rRNA Gene Enrichment Open
The broad-range detection and identification of bacterial DNA from clinical specimens are a foundational approach in the practice of molecular microbiology. However, there are circumstances under which conventional testing may yield false-…
View article: Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series
Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series Open
View article: Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury
Nitric oxide synthase mediates cerebellar dysfunction in mice exposed to repetitive blast-induced mild traumatic brain injury Open
View article: Human Hair as a Possible Surrogate Marker of Retained Tissue Gadolinium
Human Hair as a Possible Surrogate Marker of Retained Tissue Gadolinium Open
Objectives We used laser ablation inductively coupled plasma mass spectrometry to quantify gadolinium in hair samples from autopsy cases with gadolinium-based contrast agent (GBCA) exposure. Hair gadolinium data were correlated with gadoli…
View article: Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections
Histopathology and Ultrastructural Findings of Fatal COVID-19 Infections Open
Background SARS-CoV-2 is the cause of an ongoing pandemic with a projected 100,000 to 240,000 U.S. deaths. To date, documentation of histopathologic features in fatal cases of COVID-19 has been limited due to small sample size and incomple…
View article: Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons
Human cortical expansion involves diversification and specialization of supragranular intratelencephalic-projecting neurons Open
The neocortex is disproportionately expanded in human compared to mouse, both in its total volume relative to subcortical structures and in the proportion occupied by supragranular layers that selectively make connections within the cortex…
View article: Neuropathological and transcriptomic characteristics of the aged brain
Neuropathological and transcriptomic characteristics of the aged brain Open
As more people live longer, age-related neurodegenerative diseases are an increasingly important societal health issue. Treatments targeting specific pathologies such as amyloid beta in Alzheimer’s disease (AD) have not led to effective tr…
View article: Author response: Neuropathological and transcriptomic characteristics of the aged brain
Author response: Neuropathological and transcriptomic characteristics of the aged brain Open
View article: Tracheal diverticula in advanced cystic fibrosis: Prevalence, features, and outcomes after lung transplantation
Tracheal diverticula in advanced cystic fibrosis: Prevalence, features, and outcomes after lung transplantation Open
View article: Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease
Performance of a Condensed Protocol That Reduces Effort and Cost of NIA-AA Guidelines for Neuropathologic Assessment of Alzheimer Disease Open
Concerns regarding resource expenditures have been expressed about the 2012 NIA-AA Sponsored Guidelines for neuropathologic assessment of Alzheimer disease (AD) and related dementias. Here, we investigated a cost-reducing Condensed Protoco…
View article: Genome sequencing in a case of Niemann–Pick type C
Genome sequencing in a case of Niemann–Pick type C Open
Adult-onset Niemann–Pick disease type C (NPC) is an infrequent presentation of a rare neurovisceral lysosomal lipid storage disorder caused by autosomal recessive mutations in NPC1 (∼95%) or NPC2 (∼5%). Our patient was diagnosed at age 33 …