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View article: Uneven Implementation of Nirsevimab Prophylaxis Resulted in Non-Uniform Reductions in RSV-Related Hospitalizations in Italy
Uneven Implementation of Nirsevimab Prophylaxis Resulted in Non-Uniform Reductions in RSV-Related Hospitalizations in Italy Open
Background/Objectives: Respiratory syncytial virus (RSV) bronchiolitis remains a leading cause of hospitalization in infants. In the 2024–2025 season, passive newborn immunization with nirsevimab, a long-acting anti-RSV monoclonal antibody…
View article: Bronchiolitis: A Real-Life Report of Increasing Compliance to Treatment Guidelines
Bronchiolitis: A Real-Life Report of Increasing Compliance to Treatment Guidelines Open
Background: Bronchiolitis accounts for a substantial number of pediatric hospitalizations and its epidemiology closely parallels that of respiratory syncytial virus (RSV), its principal etiological agent. International guidelines recommend…
View article: Bridging the Gap: A Systematic Review with Expert Opinion on the Use of Dalbavancin for In-Label and Off-Label Indications in Pediatric Patients
Bridging the Gap: A Systematic Review with Expert Opinion on the Use of Dalbavancin for In-Label and Off-Label Indications in Pediatric Patients Open
Objectives: The aim of this work was to perform a systematic review assessing the pharmacokinetic/pharmacodynamic (PK/PD) properties of dalbavancin and the clinical use for in-label and off-label indications in pediatric patients. Methods:…
View article: Missed vaccines in pregnant women: A contributing factor to pertussis outbreak in newborns and infants
Missed vaccines in pregnant women: A contributing factor to pertussis outbreak in newborns and infants Open
View article: Echovirus 11 lineage I and other enteroviruses in hospitalized children with acute respiratory infection in Southern Italy, 2022- 2023
Echovirus 11 lineage I and other enteroviruses in hospitalized children with acute respiratory infection in Southern Italy, 2022- 2023 Open
View article: Real-World Use of Dalbavancin for Treatment of Soft Tissue and Bone Infection in Children: Safe, Effective and Hospital-Time Sparing
Real-World Use of Dalbavancin for Treatment of Soft Tissue and Bone Infection in Children: Safe, Effective and Hospital-Time Sparing Open
Acute bacterial skin and skin structure infections (ABSSSI) and osteoarticular infections compound the burden of morbidity, mortality and prolonged hospitalizations among gram-positive infections. Dalbavancin, a second-generation, intraven…
View article: Policy of vaccination of “fragile children”: Results of a survey of 14 Italian children’s hospitals
Policy of vaccination of “fragile children”: Results of a survey of 14 Italian children’s hospitals Open
Children with chronic disease are at higher risk of invasive infectious disease, including several vaccine-preventable infections. The Italian Association of Pediatric Hospitals (AOPI) carried out a survey of immunization practices: 14/16 …
View article: Hospitalization for bronchiolitis in children aged ≤ 1year, Southern Italy, year 2021: need for new preventive strategies?
Hospitalization for bronchiolitis in children aged ≤ 1year, Southern Italy, year 2021: need for new preventive strategies? Open
View article: Appropriate Use of Antibiotic and Principles of Antimicrobial Stewardship in Children
Appropriate Use of Antibiotic and Principles of Antimicrobial Stewardship in Children Open
Antibiotics account for over 10% of the overall drug expense of the National Health System in Italy in 2021. Their use in children is of particular interest on one side, because acute infections are very common in children, while they buil…
View article: Bronchiolitis 2021–2022 epidemic: multicentric analysis of the characteristics and treatment approach in 214 children from different areas in Italy
Bronchiolitis 2021–2022 epidemic: multicentric analysis of the characteristics and treatment approach in 214 children from different areas in Italy Open
View article: Correction to: Outbreak of Respiratory Syncytial Virus Bronchiolitis in Italy
Correction to: Outbreak of Respiratory Syncytial Virus Bronchiolitis in Italy Open
View article: Correction to: Stopping Hospital Infections With Environmental Services (SHINE): A Cluster-randomized Trial of Intensive Monitoring Methods for Terminal Room Cleaning on Rates of Multidrug-resistant Organisms in the Intensive Care Unit
Correction to: Stopping Hospital Infections With Environmental Services (SHINE): A Cluster-randomized Trial of Intensive Monitoring Methods for Terminal Room Cleaning on Rates of Multidrug-resistant Organisms in the Intensive Care Unit Open
View article: Le vaccinazioni nei bambini con patologia renale cronica
Le vaccinazioni nei bambini con patologia renale cronica Open
View article: Out-of-Season Epidemic of Respiratory Syncytial Virus during the COVID-19 Pandemic: The High Burden of Child Hospitalization in an Academic Hospital in Southern Italy in 2021
Out-of-Season Epidemic of Respiratory Syncytial Virus during the COVID-19 Pandemic: The High Burden of Child Hospitalization in an Academic Hospital in Southern Italy in 2021 Open
Respiratory syncytial virus (RSV) infection is the most common cause of hospitalization in young children. In the last 2 years, public health measures aimed at controlling the spread of SARS-CoV-2 have affected the epidemiology and seasona…
View article: Acute, Severe Hepatitis of Unknown Origin: Should We Really Be Afraid of Another Obscure Enemy of Our Children?
Acute, Severe Hepatitis of Unknown Origin: Should We Really Be Afraid of Another Obscure Enemy of Our Children? Open
On 31 March 2022, Public Health Scotland was alerted to five children aged 3–5 years, presenting to the Glasgow children’s hospital with severe hepatitis of unknown etiology within a 3-week period [...]
View article: Limited Additive Diagnostic Impact of Isolated Gastrointestinal Involvement for the Triage of Children with Suspected COVID-19
Limited Additive Diagnostic Impact of Isolated Gastrointestinal Involvement for the Triage of Children with Suspected COVID-19 Open
The strategy for the selection of patients with a suspected SARS-CoV-2 infection is relevant for the organization of a children’s hospital to provide optimal separation into COVID-19 and non-COVID-19 areas and pathways. We analyzed the pro…
View article: Uso appropriato degli antibiotici e stewardship in pediatria
Uso appropriato degli antibiotici e stewardship in pediatria Open
Antimicrobial resistance is a public health problem emerging in all areas of the world, making difficult to treat many common infections. Antimicrobial stewardship is an instrument to fight antimicrobial resistance. Antimicrobial stewardsh…
View article: Frequency of Bacteremia due to Carbapenemase-producing Enterobacteriaceae in Pediatric Hematology-Oncology Can Be Reduced by Measures of Hospital Infection Control
Frequency of Bacteremia due to Carbapenemase-producing Enterobacteriaceae in Pediatric Hematology-Oncology Can Be Reduced by Measures of Hospital Infection Control Open
Objectives: The spread of carbapenemase-producing Enterobacteriaceae (CPE) is an emerging problem in children undergoing cancer-directed chemotherapy. A previous Italian survey reported a threefold increase in CPE colonization rate and a f…
View article: Effectiveness of Preventive Measures in Keeping Low Prevalence of SARS-CoV-2 Infection in Health Care Workers in a Referral Children’s Hospital in Southern Italy
Effectiveness of Preventive Measures in Keeping Low Prevalence of SARS-CoV-2 Infection in Health Care Workers in a Referral Children’s Hospital in Southern Italy Open
The coronavirus disease 2019 (COVID-19) pandemic now represents a major threat to public health. Health care workers (HCW) are exposed to biological risk. Little is currently known about the risk of HCW operating in pediatric wards for SAR…
View article: SARS-CoV-2 Vaccination for Children—An Open Issue
SARS-CoV-2 Vaccination for Children—An Open Issue Open
The Covid-19 pandemic is still raging [...]
View article: Response to ‘No evidence of SARS‐CoV‐2 infection by polymerase chain reaction or serology in children with pseudo‐chilblain’. Reply from the authors
Response to ‘No evidence of SARS‐CoV‐2 infection by polymerase chain reaction or serology in children with pseudo‐chilblain’. Reply from the authors Open
Dear Editor, Recalcati et al. conclude that chilblain-like lesions (CLLs) are part of the spectrum of COVID-19 based on reports of SARS-CoV-2 in endothelial cells of skin biopsies assessed by immunohistochemistry and electron microscopy (E…
View article: SARS-CoV-2 Infection in Children in Southern Italy: A Descriptive Case Series
SARS-CoV-2 Infection in Children in Southern Italy: A Descriptive Case Series Open
At the beginning of the coronavirus-2019 (COVID-19) pandemic, Italy was one of the most affected countries in Europe. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is less frequent and less severe in children than …
View article: No evidence of SARS‐CoV‐2 infection by polymerase chain reaction or serology in children with pseudo‐chilblain
No evidence of SARS‐CoV‐2 infection by polymerase chain reaction or serology in children with pseudo‐chilblain Open
Despite its aggressive clinical course, leading to 6.4% fatality rate as of May 25, 2020 (https://qap.ecdc.europa.eu/public/extensions/COVID-19/COVID-19.html), COVID-19 turned out to be only marginally aggressive in children. In a report f…
View article: 2019-nCoV: Polite with Children!
2019-nCoV: Polite with Children! Open
A novel epidemic is challenging the global health care system. Starting from probably November to December 2019, another Coronavirus entered the arena of human pathogens, to be then defined 2019-nCoV.[...]
View article: Use of Micafungin for the Management of a Cluster of Invasive Aspergillosis in Children with Cancer
Use of Micafungin for the Management of a Cluster of Invasive Aspergillosis in Children with Cancer Open
Background: Progressive increase of the capacity to cure children with cancer makes their rescue from life-threatening infectious complications, such as invasive fungal infections, a compelling challenge. Local outbreak among patients at r…
View article: Voriconazole treatment in adults and children with hematological diseases: can it be used without measurement of plasma concentration?
Voriconazole treatment in adults and children with hematological diseases: can it be used without measurement of plasma concentration? Open
Indication and timing of trough plasma-voriconazole (VCZ)-concentration (t-PVC) measurement during VCZ treatment is a debated issue. Patterns of t-PVC were prospectively evaluated in pediatric (50 courses) and adult (95 courses) hematologi…
View article: Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration?
Posaconazole oral suspension primary prophylaxis in acute leukemia and allogeneic stem cell transplant patients: can it be used without measurement of plasma concentration? Open
Posaconazole oral suspension (PCZ-susp) can display a variable degree of inter and intra-individual absorption. However, there is no agreement on the need of plasma-posaconazole-concentration (PPC) monitoring as a routine practice in patie…
View article: Biosimilars in the management of neutropenia: focus on filgrastim
Biosimilars in the management of neutropenia: focus on filgrastim Open
Advances in chemotherapy and surgery allows the majority of patients to survive cancer diseases. Yet, the price may be a proportion of patients dying of complications due to treatment-induced infectious complications, such as neutropenia. …
View article: Incidence of colonization and bloodstream infection with carbapenem-resistant <i>Enterobacteriaceae</i> in children receiving antineoplastic chemotherapy in Italy
Incidence of colonization and bloodstream infection with carbapenem-resistant <i>Enterobacteriaceae</i> in children receiving antineoplastic chemotherapy in Italy Open
Few data are available on the incidence of carbapenemase-producing Enterobacteriaceae (CPE) infection or colonization in children receiving anticancer chemotherapy. We performed a nationwide survey among centers participating in the pediat…