Desmaré van Rooyen
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View article: SUN-240 High Discordance between Imaging and Aldosterone Synthase Immunohistochemistry in Lateralized Primary Aldosteronism
SUN-240 High Discordance between Imaging and Aldosterone Synthase Immunohistochemistry in Lateralized Primary Aldosteronism Open
Disclosure: L.M. Mermejo: None. Y. Liu: None. E. Caoili: None. D. Rooyen: None. J. Rege: None. T. Giordano: None. W. Rainey: None. A.F. Turcu: None. Background: Primary aldosteronism (PA) can originate in one or both adrenal glands. The cl…
View article: SUN-241 Comparison of Aldosterone-Producing Adenomas Harboring ATP1A1 and ATP2B3 Aldosterone-Driver Mutations
SUN-241 Comparison of Aldosterone-Producing Adenomas Harboring ATP1A1 and ATP2B3 Aldosterone-Driver Mutations Open
Disclosure: Y. Liu: None. C. Lee: None. D. Van Rooyen: None. J. Rege: None. P. Vibhatavata: None. A. Udager: None. W.E. Rainey: None. A. Turcu: None. Background: Over 90% of aldosterone-producing adenomas (APAs) harbor somatic mutations in…
View article: OR05-07 Somatic Mutations in MCOLN3 Drives Dysregulated Aldosterone Production in Aldosterone-Producing Adenomas
OR05-07 Somatic Mutations in MCOLN3 Drives Dysregulated Aldosterone Production in Aldosterone-Producing Adenomas Open
Disclosure: D. van Rooyen: None. S. Bandulik: None. G. Coon: None. M. Laukemper: None. C. Kumar-Sinha: None. A. Udager: None. A.M. Lerario: None. C. Lee: None. H. Wachtel: None. D. Cohen: None. J.M. Luther: None. T.J. Giordano: None. F. Bu…
View article: Somatic Mutations in<i>MCOLN3</i>in Aldosterone-Producing Adenomas cause Primary Aldosteronism
Somatic Mutations in<i>MCOLN3</i>in Aldosterone-Producing Adenomas cause Primary Aldosteronism Open
Primary aldosteronism is characterized by renin-independent hyperaldosteronism that originates from aldosterone-producing lesions in the adrenal glands. Under physiological conditions, aldosterone synthase ( CYP11B2 ) expression is confine…
View article: 7312 Tumor Size and Mutation Prevalence in Black Americans with Primary Aldosteronism
7312 Tumor Size and Mutation Prevalence in Black Americans with Primary Aldosteronism Open
Disclosure: D. van Rooyen: None. K. Nanba: Other; Self; AstraZeneca. D.R. Sapiro: None. A. Blinder: None. H. Wachtel: None. D. Cohen: None. J.M. Luther: Advisory Board Member; Self; consulted with Mineralys. A. Vaidya: None. T.J. Giordano:…
View article: Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens
Circulating adrenal and gonadal steroid hormones heterogeneity in active young males and the contribution of 11-oxy androgens Open
The classical androgens, testosterone and dihydrotestosterone, together with dehydroepiandrosterone, the precusrsor to all androgens, are generally included in diagnostic steroid evaluations of androgen excess and deficiency disorders and …
View article: Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism
Chronic activation of adrenal Gq signaling induces Cyp11b2 expression in the zona fasciculata and hyperaldosteronism Open
View article: C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors
C11-hydroxy and C11-oxo C19 and C21 Steroids: Pre-Receptor Regulation and Interaction with Androgen and Progesterone Steroid Receptors Open
C11-oxy C19 and C11-oxy C21 steroids have been identified as novel steroids but their function remains unclear. This study aimed to investigate the pre-receptor regulation of C11-oxy steroids by 11β-hydroxysteroid dehydrogenase (11βHSD) in…
View article: FRI192 Serum Steroid Biomarkers For The Differential Diagnosis Of Adrenocortical Carcinoma (ACC) And Adrenocortical Adenoma (ACA)
FRI192 Serum Steroid Biomarkers For The Differential Diagnosis Of Adrenocortical Carcinoma (ACC) And Adrenocortical Adenoma (ACA) Open
Disclosure: D. van Rooyen: None. R. Scheske: None. A.M. Lerario: None. W.E. Rainey: None. R.J. Auchus: None. G.D. Hammer: None. T. Else: None. Background: Adrenal tumors are very common, with the vast majority being benign adrenocortical a…
View article: SAT263 Osteocalcin Promotes Cortisol Production In Human Adrenal Cells
SAT263 Osteocalcin Promotes Cortisol Production In Human Adrenal Cells Open
Disclosure: R. Scheske: None. D. van Rooyen: None. W.E. Rainey: None. Background: Osteocalcin (OCN) is a peptide exclusively produced by osteoblasts in bone. In an uncarboxylated form, OCN has been shown to function as a hormone affecting …
View article: OR13-5 Bone Morphogenetic Protein-4 (BMP4) Inhibits Adrenal Cell Cortisol Synthesis by Blocking CYP17A1 and CYP11B1 Expression.
OR13-5 Bone Morphogenetic Protein-4 (BMP4) Inhibits Adrenal Cell Cortisol Synthesis by Blocking CYP17A1 and CYP11B1 Expression. Open
Background Cytochrome P450c17 (17α-hydroxylase, encoded by CYP17A1) and cytochrome P450c11 (11β-hydroxylase, encoded by CYP11B1) are essential for production of adrenal cortisol. The expression of CYP17A1 and CYP11B1 in adrenocortical cell…
View article: LBMON273 Not All Men Are Created Equal
LBMON273 Not All Men Are Created Equal Open
Background Clinical assessment of androgens in the diagnosis of androgen excess, hypogonadism, androgen replacement or suppressive therapy and in anti-doping practices is generally limited to a few C19 steroids. More accurate evaluations m…
View article: RF33 | PSAT79 Chronic Activation of Gq-Signaling in the Mouse Adrenal Cortex Disrupts Zonation and Causes Aldosterone Production in the Zona Fasciculata
RF33 | PSAT79 Chronic Activation of Gq-Signaling in the Mouse Adrenal Cortex Disrupts Zonation and Causes Aldosterone Production in the Zona Fasciculata Open
Background The mammalian adrenal cortex is composed of the zona glomerulosa (ZG), zona fasciculata (ZF), and in some species the zona reticularis (ZR). Each layer is characterized by a specific steroidogenic enzyme expression pattern that …
View article: Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma
Primary aldosteronism caused by a pI157S somatic KCNJ5 mutation in a black adolescent female with aldosterone-producing adenoma Open
Aldosterone-producing adenoma is a rare cause of hypertension in children. Only a limited number of cases of aldosterone-producing adenomas with somatic KCNJ5 gene mutations have been described in children. Blacks are particularly more sus…
View article: OR02-5 Novel Intermediates Are Catalysed By 11βHSD And CYP17A1 In The C11-oxy Backdoor Pathway Leading To The Production Of 11-ketodihydrotestosterone
OR02-5 Novel Intermediates Are Catalysed By 11βHSD And CYP17A1 In The C11-oxy Backdoor Pathway Leading To The Production Of 11-ketodihydrotestosterone Open
Adrenal C(19) steroids, testosterone and androstenedione, have long been the only androgens considered contributing to clinical conditions characterised by androgen excess. More recently, we showed that adrenal 11β-hydroxyandrostenedione i…
View article: The metabolism of adrenal 11beta-hydroxyprogesterone, 11keto-progesterone and 16alpha-hydroxyprogesterone by steroidogenic enzymes
The metabolism of adrenal 11beta-hydroxyprogesterone, 11keto-progesterone and 16alpha-hydroxyprogesterone by steroidogenic enzymes Open