Desmond Campbell
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View article: Developing a synthetic Brazilian population derived from the 2010 Census
Developing a synthetic Brazilian population derived from the 2010 Census Open
The 2010 Brazilian Census contains a wealth of information that could enable research and inform policies in health, education, the economy, and other sectors. The census provides publicly available information in two forms. Firstly, conti…
View article: Exploring the Design of Pedagogical Agent Roles in Collaborative STEM+C Learning
Exploring the Design of Pedagogical Agent Roles in Collaborative STEM+C Learning Open
View article: Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study
Effects of alcohol consumption on employment and social outcomes: a Mendelian randomisation study Open
Aims Alcohol consumption is associated with socioeconomic disadvantage, but causality is unclear. We used Mendelian randomisation (MR) to estimate the effect of alcohol consumption on socioeconomic and employment-related outcomes. Methods …
View article: Investigating causal effects of income on health using two-sample Mendelian randomisation
Investigating causal effects of income on health using two-sample Mendelian randomisation Open
View article: A workshop to enrich physiological understanding through hands-on learning about mitochondria-endoplasmic reticulum contact sites
A workshop to enrich physiological understanding through hands-on learning about mitochondria-endoplasmic reticulum contact sites Open
This manuscript offers a design for a workshop that utilizes blended learning to engage middle school, high school, and undergraduate students while teaching them about mitochondria-endoplasmic reticulum contact sites.
View article: A workshop to showcase the diversity of scientists to middle school students
A workshop to showcase the diversity of scientists to middle school students Open
We observed positive sentiments from middle school students following a workshop that showcased diversity in science. This workshop uniquely encourages students to recognize that physiologists and scientists today are much more diverse tha…
View article: A workshop on mitochondria for students to improve understanding of science and hypothesis forming
A workshop on mitochondria for students to improve understanding of science and hypothesis forming Open
Here we employ a workshop that utilizes blended and tactile learning to teach middle schoolers about mitochondrial structure. By creating an approachable and fun workshop that can be utilized for middle school students, we seek to encourag…
View article: Biases arising from linked administrative data for epidemiological research: a conceptual framework from registration to analyses
Biases arising from linked administrative data for epidemiological research: a conceptual framework from registration to analyses Open
View article: Impact of Brazil’s Bolsa Família Programme on cardiovascular and all-cause mortality: a natural experiment study using the 100 Million Brazilian Cohort
Impact of Brazil’s Bolsa Família Programme on cardiovascular and all-cause mortality: a natural experiment study using the 100 Million Brazilian Cohort Open
Background Cardiovascular disease (CVD) has a disproportionate effect on mortality among the poorest people. We assessed the impact on CVD and all-cause mortality of the world's largest conditional cash transfer, Brazil’s Bolsa Família Pro…
View article: Comparing Anxiety and Depression in Information Technology Workers with Others in Employment: A UK Biobank Cohort Study
Comparing Anxiety and Depression in Information Technology Workers with Others in Employment: A UK Biobank Cohort Study Open
Objectives Despite reported psychological hazards of information technology (IT) work, studies of diagnosed mental health conditions in IT workers are lacking. We investigated self-reported mental health outcomes and incident anxiety/depre…
View article: Biases arising from using linked administrative data for research: A conceptual framework from registration to analysis.
Biases arising from using linked administrative data for research: A conceptual framework from registration to analysis. Open
ObjectivesAdministrative data are primarily collected for operational processes and these processes can lead to sources of bias that may not be adequately considered by researchers. We provide a framework to help understand how biases migh…
View article: Effects of depression on employment and social outcomes: a Mendelian randomisation study
Effects of depression on employment and social outcomes: a Mendelian randomisation study Open
Background Depression is associated with socioeconomic disadvantage. However, whether and how depression exerts a causal effect on employment remains unclear. We used Mendelian randomisation (MR) to investigate whether depression affects e…
View article: Effects of increased body mass index on employment status: a Mendelian randomisation study
Effects of increased body mass index on employment status: a Mendelian randomisation study Open
View article: Clinical burden, risk factor impact and outcomes following myocardial infarction and stroke: A 25-year individual patient level linkage study
Clinical burden, risk factor impact and outcomes following myocardial infarction and stroke: A 25-year individual patient level linkage study Open
View article: Mental health and health behaviours before and during the initial phase of the COVID-19 lockdown: longitudinal analyses of the UK Household Longitudinal Study
Mental health and health behaviours before and during the initial phase of the COVID-19 lockdown: longitudinal analyses of the UK Household Longitudinal Study Open
Background There are concerns that COVID-19 mitigation measures, including the ‘lockdown’, may have unintended health consequences. We examined trends in mental health and health behaviours in the UK before and during the initial phase of …
View article: Mental health and health behaviours before and during the initial phase of the COVID-19 lockdown: Longitudinal analyses of the UK Household Longitudinal Study
Mental health and health behaviours before and during the initial phase of the COVID-19 lockdown: Longitudinal analyses of the UK Household Longitudinal Study Open
Background There are concerns that COVID-19 mitigation measures, including the “lockdown”, may have unintended health consequences. We examined trends in mental health and health behaviours in the UK before and during the initial phase of …
View article: The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank
The causal effects of health conditions and risk factors on social and socioeconomic outcomes: Mendelian randomization in UK Biobank Open
Background We aimed to estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments, polic…
View article: Estimated effects of health conditions and risk factors on social and socioeconomic outcomes: mendelian randomisation of UK Biobank data
Estimated effects of health conditions and risk factors on social and socioeconomic outcomes: mendelian randomisation of UK Biobank data Open
View article: The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes: Mendelian Randomization in UK Biobank
The Causal Effects of Health Conditions and Risk Factors on Social and Socioeconomic Outcomes: Mendelian Randomization in UK Biobank Open
Objectives To estimate the causal effect of health conditions and risk factors on social and socioeconomic outcomes in UK Biobank. Evidence on socioeconomic impacts is important to understand because it can help governments, policy-makers …
View article: Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes
Salt stress in the renal tubules is linked to TAL-specific expression of uromodulin and an upregulation of heat shock genes Open
Previously, our comprehensive cardiovascular characterization study validated Uromodulin as a blood pressure gene. Uromodulin is a glycoprotein exclusively synthesized at the thick ascending limb of the loop of Henle and is encoded by the …
View article: 133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study
133. Interplay Between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study Open
Background: A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosi…
View article: Sacral agenesis: a pilot whole exome sequencing and copy number study
Sacral agenesis: a pilot whole exome sequencing and copy number study Open
View article: Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes
Genetic study of congenital bile-duct dilatation identifies de novo and inherited variants in functionally related genes Open
Our data supports a strong genetic basis for CDD and show that CDD is not only genetically heterogeneous but also non-monogenic, requiring mutations in more than one genes for the disease to develop. The data is consistent with the rarity …
View article: Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study
Interplay between Schizophrenia Polygenic Risk Score and Childhood Adversity in First-Presentation Psychotic Disorder: A Pilot Study Open
A history of childhood adversity is associated with psychotic disorder, with an increase in risk according to number or severity of exposures. However, it is not known why only some exposed individuals go on to develop psychosis. One possi…
View article: Sacral agenesis: A pilot whole exome sequencing and copy number study
Sacral agenesis: A pilot whole exome sequencing and copy number study Open
Background Caudal regression syndrome (CRS) or sacral agenesis is a rare congenital disorder characterized by a constellation of congenital caudal anomalies affecting the caudal spine and spinal cord, the hindgut, the urogenital system, an…
View article: Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study
Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study Open
View article: A Single Nucleotide Variant in HNF-1β is Associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family.
A Single Nucleotide Variant in HNF-1β is Associated with Maturity-Onset Diabetes of the Young in a Large Chinese Family. Open
This novel SNV of HNF-1β contributes to the diabetes development in the family through regulating gene expression most likely. The findings help presymptomatic diagnosis, and imply that mutations in the non-coding areas, as well as in the …
View article: Erratum: Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort
Erratum: Reciprocal causation models of cognitive vs volumetric cerebral intermediate phenotypes for schizophrenia in a pan-European twin cohort Open
View article: Cost effective assay choice for rare disease study designs
Cost effective assay choice for rare disease study designs Open