Desmond N. Jackson
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View article: Unpacking rural Heterogeneity: A proof-of-concept study of how varying rural contexts shape breast cancer screening behaviors
Unpacking rural Heterogeneity: A proof-of-concept study of how varying rural contexts shape breast cancer screening behaviors Open
Addressing rural BrCa screening inequities requires more than generic rural interventions; this study demonstrates that inequities may manifest differently across rural types, with distinct underlying dynamics shaping barriers. By showing …
View article: Functional Amyloids in Adhesion of Non-albicans Candida Species
Functional Amyloids in Adhesion of Non-albicans Candida Species Open
Candida fungal species are the most common fungal opportunistic pathogens. Their ability to form antifungal resistant biofilms contributes to their increasing clinical frequency. These fungi express surface-anchored adhesins including memb…
View article: Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and Infections
Amyloid-Like β-Aggregates as Force-Sensitive Switches in Fungal Biofilms and Infections Open
SUMMARY Cellular aggregation is an essential step in the formation of biofilms, which promote fungal survival and persistence in hosts. In many of the known yeast cell adhesion proteins, there are amino acid sequences predicted to form amy…
View article: Force Sensitivity in Saccharomyces cerevisiae Flocculins
Force Sensitivity in Saccharomyces cerevisiae Flocculins Open
The Saccharomyces cerevisiae flocculins mediate the formation of cellular aggregates and biofilm-like mats, useful in clearing yeast from fermentations. An important property of fungal adhesion proteins, including flocculins, is the abilit…
View article: The Human Disease-Associated Aβ Amyloid Core Sequence Forms Functional Amyloids in a Fungal Adhesin
The Human Disease-Associated Aβ Amyloid Core Sequence Forms Functional Amyloids in a Fungal Adhesin Open
There is increasing evidence that many amyloids in living cells have physiological functions. On the surfaces of fungal cells, amyloid core sequences in adhesins can aggregate into 100- to 1,000-nm-wide patches to form high-avidity adhesio…