Explanipedia

Effects of Oxygen Manipulation on Myofibroblast Phenotypic Transformation in Patients With Radiation‐Induced Fibrosis Open

Eric V. Mastrolonardo, Sarah Sussman, Bo Hyon Yun, Victor Jegede, Dev Amin , et al. · 2025

We tested if hyperoxic conditions can reduce the proportion of active myofibroblasts, which are assumed to be a major driver of head and neck radiation‐induced fibrosis, as measured by expression levels of pro‐fibrotic genes. Radiated, non…

Improved survival with elevated BMI following immune checkpoint inhibition across various solid tumor cancer types Open

Eric V. Mastrolonardo, Pablo Llerena, Emma De Ravin, Kathryn L. Nunes, Praneet C. Kaki , et al. · 2025

Studies investigating the clinical benefits of obesity across various cancer types are limited. This big data study demonstrates that obesity is associated with improved overall survival up to 5 years after treatment with immune checkpoint…

Outcomes and Complications of 2‐Stage Versus 3‐Stage Paramedian Forehead Flaps Open

William J. Palmer, Dev Amin, Praneet C. Kaki, Matthew M. Davis, Eric Fei , et al. · 2025

Objective This study aims to explore outcomes among 2‐stage paramedian forehead flaps (PFFs), 3‐stage PFFs, and PFFs undergoing accelerated pedicle takedown. Study Design A retrospective review. Setting A tertiary care institution. Methods…

Patient‐Reported Outcome Measures for Mohs Reconstruction: A Systematic Review Open

Neha Garg, Shreya Mandloi, Natalia Queenan, Jay Trivedi, Adam McCann , et al. · 2024

Objective Mohs micrographic surgery (MMS) and subsequent reconstructive procedures for the treatment of facial nonmelanoma skin cancers (NMSCs) significantly impact quality of life (QoL). A validated patient‐reported outcome measure (PROM)…

Obesity and Survival After Immune Checkpoint Inhibition for Head and Neck Squamous Cell Carcinoma Open

Eric V. Mastrolonardo, Pablo Llerena, Joseph Lu, Kathryn L. Nunes, Grace Choi , et al. · 2024

Importance For patients treated with immune checkpoint inhibitors (ICIs), recent data suggest that obesity has a beneficial effect on survival outcomes in various cancer types. Reports on this association in head and neck cancer are limite…

Modified Frailty Index Associates With Transoral Robotic Surgery Complications and Survival: A National Database Study Open

Amiti Jain, Zachary N. Goldberg, Erin E. Briggs, Dev Amin, Zachary D. Urdang , et al. · 2024

Objective The modified frailty index (mFI‐5) is a National Surgical Quality Improvement Program‐derived 5‐factor index that has been proven to reflect frailty and predict morbidity and mortality. We hypothesize that mFI‐5 is a valid predic…

A novel staging system to consolidate silent sinus syndrome and chronic maxillary atelectasis: A systematic review and case series Open

Dev Amin, Shreya Mandloi, Kathryn L. Nunes, Neha Garg, Chase Kahn , et al. · 2024

Key points Silent sinus syndrome (SSS) and chronic maxillary atelectasis (CMA) represent an overlapping clinical entity, both likely lying on the spectrum of one disease process. There is widespread inconsistency of diagnosis in the litera…

Safety of Ambulatory Surgery For Obstructive Sleep Apnea: A Retrospective Review Open

Dylan Bertoni, Emily Garvey, Neha Garg, Dev Amin, Sruti Tekumalla , et al. · 2024

Objective Assess the safety of ambulatory surgery performed for obstructive sleep apnea. Study Design Retrospective chart review. Setting Tertiary care hospital. Methods Demographic data including age, gender, race, body mass index, insura…

Microvascular reconstruction of medication related osteonecrosis of the head and neck Open

Larissa Sweeny, Sallie Long, Patrik Pipkorn, Mark K. Wax, Carissa M. Thomas , et al. · 2024

Background Medication related osteonecrosis of the jaw (MRONJ) requiring free flap (FF) reconstruction is uncommon with limited reported findings. Methods Multicenter, retrospective case series of 49 consecutive adult patients presenting w…

Effect of preoperative programmed death‐1 or programmed death ligand‐1 immune check point inhibition on complications after surgery for primary head and neck cancer Open

Ramez Philips, Angela Alnemri, Dev Amin, Jena Patel, Michael C. Topf , et al. · 2023

Background There is sparse literature on the effect of preoperative immunotherapy on complications after surgery for primary head and neck squamous cell carcinoma (HNSCC). The objectives are to compare complication rates in patients receiv…

Complications and Functional Outcomes After Esophageal Reconstruction with an Intact Larynx Open

Aarti Agarwal, Ramez Philips, Michele Fiorella, Dev Amin, Howard Krein , et al. · 2023

Background Esophageal defects can result from primary pathologies such as malignancy or stricture, or secondary ones such as perforation due to trauma or iatrogenic injury. Techniques, management, and outcomes of reconstruction in this set…

Evaluating ChatGPT responses on obstructive sleep apnea for patient education Open

Daniel J. Campbell, Leonard E. Estephan, Eric V. Mastrolonardo, Dev Amin, Colin Huntley , et al. · 2023

Differences in Functional and Survival Outcomes Between Patients Receiving Primary Surgery vs Chemoradiation Therapy for Treatment of T1-T2 Oropharyngeal Squamous Cell Carcinoma Open

Dev Amin, Ramez Philips, Dylan Bertoni, Eric V. Mastrolonardo, Daniel J. Campbell , et al. · 2023

Importance Due to lack of data from high-powered randomized clinical trials, the differences in functional and survival outcomes for patients with oropharyngeal squamous cell carcinoma (OPSCC) undergoing primary transoral robotic surgery (…

Metformin Clinical Trial in HPV+ and HPV– Head and Neck Squamous Cell Carcinoma: Impact on Cancer Cell Apoptosis and Immune Infiltrate Open

Joseph Curry, Jennifer M. Johnson, Mehri Mollaee, Patrick Tassone, Dev Amin , et al. · 2018

Background: Metformin, an oral anti-hyperglycemic drug which inhibits mitochondrial complex I and oxidative phosphorylation has been reported to correlate with improved outcomes in head and neck squamous cell carcinoma (HNSCC) and o…

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