Davangere P. Devanand
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View article: Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory
Disrupted Energetic and Entropic Landscape in Individuals With Mild Cognitive Impairment: Insights From Network Control Theory Open
The energetic and entropic organization of the brain's functional activity in mild cognitive impairment (MCI) has yet to be fully characterized. Network Control Theory (NCT) is a multi‐modal approach that captures alterations in the brain'…
View article: A proof-of-concept study: investigating the impact of COMT genotype and proline on negative symptoms in Alzheimer’s disease
A proof-of-concept study: investigating the impact of COMT genotype and proline on negative symptoms in Alzheimer’s disease Open
Background Negative neuropsychiatric symptoms, such as apathy, are a core feature of Alzheimer’s disease. Previous studies have shown that levels of fasting plasma proline and differential activity of the catechol-O-methyltransferase (COMT…
View article: Performance on a novel odor recognition memory test preferentially associates with specific cognitive measures and psychophysical characteristics
Performance on a novel odor recognition memory test preferentially associates with specific cognitive measures and psychophysical characteristics Open
Background Olfaction and memory are each independently disrupted in Alzheimer's disease (AD) early in the clinical course. Odor memory measures combining these two systems may be more capable of distinguishing these disorders than measure …
View article: Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Clinical Trial
Antiviral therapy: Valacyclovir Treatment of Alzheimer's Disease (VALAD) Clinical Trial Open
Background Infections may be etiologic or contribute to Alzheimer’s disease (AD) pathology. Evidence from neuroscience, epidemiology, and electronic health records data implicates herpes simplex viruses in AD, but controlled clinical trial…
View article: The Tau Progression Index (TPI): an individualized, clinically applicable, multimodally‐derived score to predict AD progression
The Tau Progression Index (TPI): an individualized, clinically applicable, multimodally‐derived score to predict AD progression Open
Background Alzheimer's Disease (AD) prognosis is extremely heterogeneous, even with a similar burden of global tau and amyloid (Aβ) deposition in the brain, which makes it challenging to develop targeted therapeutic interventions and to co…
View article: Disrupted Energy Landscape in Individuals with Mild Cognitive Impairment: Insights from Network Control Theory
Disrupted Energy Landscape in Individuals with Mild Cognitive Impairment: Insights from Network Control Theory Open
Introduction Patients with mild cognitive impairment (MCI) have shown disruptions in both brain structure and function, often studied separately. However, understanding the relationship between brain structure and function can provide valu…
View article: Performance of a smell identification test versus the Mini-Mental Status Exam for the detection of dementia and cognitive impairment among persons with cognitive concerns in primary care
Performance of a smell identification test versus the Mini-Mental Status Exam for the detection of dementia and cognitive impairment among persons with cognitive concerns in primary care Open
Background Odor identification deficits predict Alzheimer's disease (AD) in epidemiological studies. Objective To compare the accuracy of a short odor identification test with a short cognitive screening test for the detection of dementia …
View article: Interrelatedness of Neurocognitive Domain Functioning Between Unprompted and Prompted Identification Testing With Psychophysical Olfactory Evaluation in a Post‐COVID‐19 Cohort
Interrelatedness of Neurocognitive Domain Functioning Between Unprompted and Prompted Identification Testing With Psychophysical Olfactory Evaluation in a Post‐COVID‐19 Cohort Open
Objective Assessment of olfactory function with psychophysical testing requires cognitive demand to correctly pair test odors with remembered scents. Individuals suffering from long‐Corona Virus Disease 2019 (long‐COVID‐19) may develop a d…
View article: Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium
Exploring the role of T cells in Alzheimer's and other neurodegenerative diseases: Emerging therapeutic insights from the T Cells in the Brain symposium Open
This proceedings article summarizes the inaugural “T Cells in the Brain” symposium held at Columbia University. Experts gathered to explore the role of T cells in neurodegenerative diseases. Key topics included characterization of antigen‐…
View article: Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction
Depression, Anxiety, and Neuropsychiatric Symptom Burden in a Longitudinal Cohort with Persistent Psychophysical Post-COVID Olfactory Dysfunction Open
Background/Objectives: Olfactory dysfunction (OD) is associated with a variety of neurologic deficits and impacts socialization decisions, mood, and overall quality of life. As a common symptom comprising the long COVID condition, persiste…
View article: Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference
Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference Open
The immune system is a key player in the onset and progression of neurodegenerative disorders. While brain resident immune cell‐mediated neuroinflammation and peripheral immune cell (eg, T cell) infiltration into the brain have been shown …
View article: Decreased entropy of functional MRI signals in individuals with mild cognitive impairment compared to cognitively normal controls
Decreased entropy of functional MRI signals in individuals with mild cognitive impairment compared to cognitively normal controls Open
Background Mild cognitive impairment (MCI) is a clinical cognitive deficit that is not severe enough to meet the threshold for Alzheimer's Disease (AD); however, MCI patients have an increased risk of developing AD. Therefore, a diagnosis …
View article: Accuracy of intact performance on measures of odor identification, global cognition, and amyloid imaging for identifying lack of cognitive decline and dementia in the Mayo Clinic Study of Aging cohort
Accuracy of intact performance on measures of odor identification, global cognition, and amyloid imaging for identifying lack of cognitive decline and dementia in the Mayo Clinic Study of Aging cohort Open
Background Previous studies have linked impaired odor identification and global cognition with increased risk of cognitive decline and transition to dementia. However, the reverse question remains: if individuals have intact performance on…
View article: Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database
Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database Open
Background Our goal in this study was to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) …
View article: Comparison of Relative Change with Effect Size Metrics in Alzheimer’s Disease Anti‐amyloid Clinical Trials
Comparison of Relative Change with Effect Size Metrics in Alzheimer’s Disease Anti‐amyloid Clinical Trials Open
Background Percent slowing of decline is frequently used as a metric of outcome in Alzheimer’s disease (AD) clinical trials, but it may be misleading. Our objective was to determine whether percent slowing of decline or Cohen’s d is the mo…
View article: Performance of a smell identification test vs. the mini‐mental status exam for the detection of dementia and cognitive impairment among ethnically diverse persons with cognitive concerns in primary care
Performance of a smell identification test vs. the mini‐mental status exam for the detection of dementia and cognitive impairment among ethnically diverse persons with cognitive concerns in primary care Open
Background Early detection of dementia and cognitive impairment is recommended for persons 65 years and older during wellness primary care visits. The importance of early detection has increased with the availability of new treatments for …
View article: Comparison of olfactory and cognitive measures to neuroimaging biomarkers in the prediction of cognitive decline and dementia in the MCSA cohort
Comparison of olfactory and cognitive measures to neuroimaging biomarkers in the prediction of cognitive decline and dementia in the MCSA cohort Open
Background Inexpensive, non‐invasive tests may improve the identification of persons at increased risk for cognitive decline and dementia. We compared impairment in odor identification and global cognition with neuro‐imaging biomarkers to …
View article: Comparison of brief olfactory and cognitive assessments to neuroimaging biomarkers in the prediction of cognitive decline and dementia in the MCSA cohort
Comparison of brief olfactory and cognitive assessments to neuroimaging biomarkers in the prediction of cognitive decline and dementia in the MCSA cohort Open
INTRODUCTION We evaluated impaired odor identification and global cognition as simple, cost‐effective alternatives to neuroimaging biomarkers to predict cognitive decline and dementia in the Mayo Clinic Study of Aging. METHODS Six hundred …
View article: Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures
Novel measures of cognition and function for the AD spectrum in the Novel Measures for Alzheimer's Disease Prevention Trials (NoMAD) project: Psychometric properties, convergent validation, and contrasts with established measures Open
INTRODUCTION This study derived composite scores for two novel cognitive measures, the No Practice Effect (NPE) battery and the Miami Computerized Functional Skills Assessment and Training system for use in early‐stage Alzheimer's disease …
View article: Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort – CORRIGENDUM
Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort – CORRIGENDUM Open
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View article: Recovery rates of persistent post‐COVID‐19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study
Recovery rates of persistent post‐COVID‐19 olfactory dysfunction using psychophysical assessment: A longitudinal cohort study Open
Objectives Persistent olfactory dysfunction (OD) following loss of smell associated with SARS‐CoV‐2 infection is a major feature of long COVID. Perspectives on the prevalence of persistent OD predominantly rely on self‐reported olfactory f…
View article: Sleep–wake behavior, perceived fatigability, and cognitive reserve in older adults
Sleep–wake behavior, perceived fatigability, and cognitive reserve in older adults Open
INTRODUCTION The effects of sleep–wake behavior on perceived fatigability and cognitive abilities when performing daily activities have not been investigated across levels of cognitive reserve (CR). METHODS CR Index Questionnaire (CRIq) da…
View article: Association Between Multisensory Impairment and Depression Among Older Adults: A Population‐Based Analysis
Association Between Multisensory Impairment and Depression Among Older Adults: A Population‐Based Analysis Open
Objective In this study, we examine how impairments in vision, hearing, touch, and olfaction relate to depression in older adults, considering both individual and multisensory impairments (MSIs). Study Design Analysis of cross‐sectional da…
View article: Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent
Remote Associations Between Tau and Cortical Amyloid-β Are Stage-Dependent Open
Background: Histopathologic studies of Alzheimer’s disease (AD) suggest that extracellular amyloid-β (Aβ) plaques promote the spread of neurofibrillary tau tangles. However, these two proteinopathies initiate in spatially distinct brain re…
View article: Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database
Effects of APOE e4 and Neuropathological Diagnoses on Neuropsychiatric Symptoms: Mediation Analyses and Likely Causation in an Integrated NACC Database Open
Background Our goal in this study was to identify paths from APOE e4 to neurobehaviors itemized on a neuropsychiatric inventory that involved neuropathologies associated with e4 (amyloid, tau, cerebral amyloid angiopathy, and Lewy bodies) …
View article: Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index
Characterizing Neighborhood Vulnerabilities in Mild Cognitive Impairment using the Environmental Justice Index Open
Background: There is a need for integration and comprehensive characterization of environmental determinants of Alzheimer’s disease. The Environmental Justice Index (EJI) is a new measure that consolidates multiple environmental health haz…
View article: Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort
Effects of age on the relationship between sleep quality and cognitive performance: Findings from the Human Connectome Project-Aging cohort Open
The sleep-cognition relationship may be modified by age. Individuals in the middle age to early older adulthood age band may be most vulnerable to sleep-related cognitive impairment.
View article: The risk of sleep‐related cognitive impairment increases in middle‐age to older adulthood
The risk of sleep‐related cognitive impairment increases in middle‐age to older adulthood Open
Background The association between sleep quality and cognition is widely established but the role of aging in this relationship has been unclear due to inconsistent findings with heterogeneous methods and a lack of studies in wide age rang…
View article: Hub brain regions for the remote spatial association between tau and Amyloid‐β proteins
Hub brain regions for the remote spatial association between tau and Amyloid‐β proteins Open
Background The pathology of Alzheimer’s disease (AD) is characterized by two types of proteins: intracellular neurofibrillary tau tangles and extracellular β‐amyloid (Aβ) plaques. In the present observational studies, spatial discrepancies…