Devanjan Dey
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View article: Defining the Immune States of the Cholinergic Anti-Inflammatory Pathway in Obesity-Driven Chronic Inflammation 4692
Defining the Immune States of the Cholinergic Anti-Inflammatory Pathway in Obesity-Driven Chronic Inflammation 4692 Open
Description Background Obesity is a state of chronic low-grade inflammation, where alterations in the immune landscape plays a central role. Cholinergic anti-inflammatory pathway (CAP), mediated by acetylcholine (ACh) and its receptor α7nA…
View article: Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets
Co-transplantation of mesenchymal stem cells and endothelial cells with islet grafts: A strategy to improve post-tx engraftment of pancreatic islets Open
Though islet transplantation is now being considered as a gold standard to cure type 1 diabetes in patients without the threat of unaware hypoglycemia and severe hypoglycemia episode, post-transplantation islet loss due to the loss of intr…
View article: Using human fetal neural stem cells to elucidate the role of the JAK-STAT cell signaling pathway in oligodendrocyte differentiation in vitro
Using human fetal neural stem cells to elucidate the role of the JAK-STAT cell signaling pathway in oligodendrocyte differentiation in vitro Open
Oligodendrocytes (OL) are the myelinating cells of the central nervous system that mediate nerve conduction. Loss of oligodendrocytes results in demyelination, triggering neurological deficits. Developing a better understanding of the cell…
View article: Phenotypic Profiling of Immune Cells and Their Mediators in Chronic Obstructive Pulmonary Disease
Phenotypic Profiling of Immune Cells and Their Mediators in Chronic Obstructive Pulmonary Disease Open
Background: Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder and has been proposed to have an imbalance between pro-inflammatory and anti-inflammatory factors. Methods: This study was conducted on 41 participants {1…
View article: Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway
Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway Open
Fetal neural stem cells (FNSCs) present in the human fetal brain, differentiate into cells of neuronal and glial lineages. The developing fetus is exposed to lower oxygen concentrations compared to adults and this physiological hypoxia may…
View article: Glutamate Uptake Is Not Impaired by Hypoxia in a Culture Model of Human Fetal Neural Stem Cell-Derived Astrocytes
Glutamate Uptake Is Not Impaired by Hypoxia in a Culture Model of Human Fetal Neural Stem Cell-Derived Astrocytes Open
Hypoxic ischemic injury to the fetal and neonatal brain is a leading cause of death and disability worldwide. Although animal and culture studies suggest that glutamate excitotoxicity is a primary contributor to neuronal death following hy…
View article: Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway
Hypoxia induces early neurogenesis in human fetal neural stem cells by activating the WNT pathway Open
Fetal neural stem cells (FNSCs) are present in the brain of human fetuses that differentiate into cells of neuronal and glial lineages. Difference in oxygen concentration between maternal and fetal circulation indicates that the developing…
View article: Human fetal neural stem cell-derived astrocytes maintain glutamate transport after hypoxic injury <i>in vitro</i>
Human fetal neural stem cell-derived astrocytes maintain glutamate transport after hypoxic injury <i>in vitro</i> Open
Astrocytes are the most abundant glial cells that play many critical roles in the central nervous system physiology including the uptake of excess glutamate from the synapse by Excitatory Amino Acid Transporters (EAATs). Among the EAATs, E…