Deepak K. Gupta
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View article: Barriers and facilitators to accessing and providing palliative care to people with cancer in the Bathinda district in Punjab: a qualitative study
Barriers and facilitators to accessing and providing palliative care to people with cancer in the Bathinda district in Punjab: a qualitative study Open
Clinical Trials Registry of India (CTRI/2023/04/051357; dated 06/04/2023).
View article: Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF
Wnt5a-mediated Adipo-Cardiac Interorgan Communication in HFpEF Open
Background Obesity is an important risk factor in heart failure with preserved ejection fraction (HFpEF), but the precise mechanisms that drive obesity-associated cardiac remodeling are not well understood. Our previous work has shown that…
View article: Metabolomic Biomarkers and Signature of Ultra-processed Foods Intake and Cardiovascular Morbidity and Mortality
Metabolomic Biomarkers and Signature of Ultra-processed Foods Intake and Cardiovascular Morbidity and Mortality Open
Ultra-processed foods (UPFs) intake may increase cardiovascular disease (CVD) risk, but the mechanisms remain unclear and evidence on UPF biomarkers is limited. Leveraging untargeted blood metabolomics in three prospective cohorts, we iden…
View article: Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure
Integrated multiomics of pressure overload in the human heart prioritizes targets relevant to heart failure Open
Pressure overload initiates a series of alterations in the human heart that predate macroscopic organ-level remodeling and downstream heart failure. We study aortic stenosis through integrated proteomic, tissue transcriptomic, and genetic …
View article: Underexplored Corrective Chronotropy-Inotropy Especially Peri-Anaesthesia for Reconstructive Surgeries
Underexplored Corrective Chronotropy-Inotropy Especially Peri-Anaesthesia for Reconstructive Surgeries Open
View article: Cardio-rheumatology: integrated care and the opportunities for personalized medicine
Cardio-rheumatology: integrated care and the opportunities for personalized medicine Open
While severe vasculopathic manifestations of systemic sclerosis (SSc) are well-recognized, characterization of subclinical progressive vasculopathy contributing to cardiac involvement remains an unmet clinical need. This review highlights …
View article: TumorHoPe2: An updated database for Tumor Homing Peptides
TumorHoPe2: An updated database for Tumor Homing Peptides Open
Addressing the growing need for organized data on tumor homing peptides (THPs), we present TumorHoPe2, a manually curated database offering extensive details on experimentally validated THPs. This represents a significant update to TumorHo…
View article: Stress Echocardiography for Assessment of Diastolic Function
Stress Echocardiography for Assessment of Diastolic Function Open
Purpose of Review Diastolic dysfunction is an important, though often underappreciated, cause for exertional dyspnea. Echocardiography enables noninvasive evaluation of diastolic function and filling pressure, but images acquired at rest m…
View article: Left Ventricular Wall Stress and Incident Heart Failure in Elderly Community-Dwelling Individuals
Left Ventricular Wall Stress and Incident Heart Failure in Elderly Community-Dwelling Individuals Open
Among community-dwelling elderly individuals, greater LVEDWS is associated with a higher risk for incident HF.
View article: Observation of Unique Practices: Metoclopramide Prior to Aortic Cannulation and ‘AUTO-agitating’ Diluted Propofol for Contrast Echocardiography
Observation of Unique Practices: Metoclopramide Prior to Aortic Cannulation and ‘AUTO-agitating’ Diluted Propofol for Contrast Echocardiography Open
View article: Associations of neighborhood sociodemographic environment with mortality and circulating metabolites among low-income black and white adults living in the southeastern United States
Associations of neighborhood sociodemographic environment with mortality and circulating metabolites among low-income black and white adults living in the southeastern United States Open
Background Residing in a disadvantaged neighborhood has been linked to increased mortality. However, the impact of residential segregation and social vulnerability on cause-specific mortality is understudied. Additionally, the circulating …
View article: Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations
Blood Lipids, Lipoproteins, and Apolipoproteins With Risk of Coronary Heart Disease: A Prospective Study Among Racially Diverse Populations Open
Background Comprehensive blood lipoprotein profiles and their association with incident coronary heart disease (CHD) among racially and geographically diverse populations remain understudied. Methods and Results We conducted nested case–co…
View article: Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B‐type natriuretic peptide hormone: Results from a randomized controlled crossover study
Human adipose tissue expression of uncoupling protein 1 in response to intravenous administration of B‐type natriuretic peptide hormone: Results from a randomized controlled crossover study Open
Obesity is associated with an increased risk of cardiovascular and metabolic diseases. Despite surgical and pharmacological approaches to reduce weight, limitations due to contraindications, adverse effects, and lack of durable efficacy ne…
View article: Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial
Correlates of Plasma NT‐proBNP/Cyclic GMP Ratio in Heart Failure With Preserved Ejection Fraction: An Analysis of the RELAX Trial Open
Background Phosphodiesterases degrade cyclic GMP (cGMP), the second messenger that mediates the cardioprotective effects of natriuretic peptides. High natriuretic peptide/cGMP ratio may reflect, in part, phosphodiesterase activity. Correla…
View article: Sodium Intake and Cause-Specific Mortality Among Predominantly Low-Income Black and White US Residents
Sodium Intake and Cause-Specific Mortality Among Predominantly Low-Income Black and White US Residents Open
IMPORTANCE Epidemiologic evidence regarding the outcomes of dietary sodium intake on mortality remains limited for low-income individuals, particularly Black people. OBJECTIVE To investigate the associations of excessive dietary sodium wit…
View article: Ratios Of Submitted Charge Amounts To Medicare Allowed Amounts Have Variably Worsened For Anesthesiologists And Certified Registered Nurse Anesthetists Serving Medicare Beneficiaries Across The United States During 2013-2021 Period
Ratios Of Submitted Charge Amounts To Medicare Allowed Amounts Have Variably Worsened For Anesthesiologists And Certified Registered Nurse Anesthetists Serving Medicare Beneficiaries Across The United States During 2013-2021 Period Open
Background Interstate variations among anesthesia providers in terms of their submitted charge amounts with corresponding Medicare allowed amounts have not been recently explored. Objective To quantify interstate variations in submitted ch…
View article: Perioperative Enteral Fasting Duration was Commonly More Than 10 h amongst Patients Undergoing Extracapsular Cataract Extraction with Intraocular Lens Implantation: A Cross-sectional Single-centric Retrospective Study from the United States
Perioperative Enteral Fasting Duration was Commonly More Than 10 h amongst Patients Undergoing Extracapsular Cataract Extraction with Intraocular Lens Implantation: A Cross-sectional Single-centric Retrospective Study from the United States Open
View article: Left Ventricular Wall Stress in Older Adults
Left Ventricular Wall Stress in Older Adults Open
View article: Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size
Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size Open
BACKGROUND: Greater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not we…
View article: Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans
Metabolite Signature of Life’s Essential 8 and Risk of Coronary Heart Disease Among Low-Income Black and White Americans Open
Background: Life’s essential 8 (LE8) is a comprehensive construct of cardiovascular health. Yet, little is known about the LE8 score, its metabolic correlates, and their predictive implications among Black Americans and low-income individu…
View article: Effect of Dietary Sodium on Blood Pressure
Effect of Dietary Sodium on Blood Pressure Open
Importance Dietary sodium recommendations are debated partly due to variable blood pressure (BP) response to sodium intake. Furthermore, the BP effect of dietary sodium among individuals taking antihypertensive medications is understudied.…
View article: Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF
Myeloid Cell Derived IL1β Contributes to Pulmonary Hypertension in HFpEF Open
BACKGROUND: Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are poorly understood. We sought to determine whether a well-accepted…
View article: Atrial Fibrillation Burden and Atrial Shunt Therapy in Heart Failure With Preserved Ejection Fraction
Atrial Fibrillation Burden and Atrial Shunt Therapy in Heart Failure With Preserved Ejection Fraction Open
View article: Myocardial Neprilysin Is Increased in Hypertrophic Cardiomyopathy
Myocardial Neprilysin Is Increased in Hypertrophic Cardiomyopathy Open
View article: Immune Checkpoint Inhibitors’ Effects on Calcified Aortic Plaques in Melanoma Survivors
Immune Checkpoint Inhibitors’ Effects on Calcified Aortic Plaques in Melanoma Survivors Open
View article: Metabolic Signatures of Cardiac Dysfunction, Multimorbidity, and Post–Transcatheter Aortic Valve Implantation Death
Metabolic Signatures of Cardiac Dysfunction, Multimorbidity, and Post–Transcatheter Aortic Valve Implantation Death Open
Background Studies in mice and small patient subsets implicate metabolic dysfunction in cardiac remodeling in aortic stenosis, but no large comprehensive studies of human metabolism in aortic stenosis with long‐term follow‐up and character…
View article: Racial differences in low natriuretic peptide levels: Implications for heart failure clinical trials
Racial differences in low natriuretic peptide levels: Implications for heart failure clinical trials Open
View article: Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure Open
Aims Heart failure with preserved ejection fraction (HFpEF) is characterized by diastolic dysfunction, microvascular dysfunction, and myocardial fibrosis with recent evidence implicating the immune system in orchestrating cardiac remodelli…
View article: Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction
Myeloid Cell Derived IL1β Contributes to Pulmonary Vascular Remodeling in Heart Failure with Preserved Ejection Fraction Open
Background Pulmonary hypertension (PH) in heart failure with preserved ejection fraction (HFpEF) is a common and highly morbid syndrome, but mechanisms driving PH-HFpEF are not well understood. We sought to determine whether a well-accepte…
View article: The Impact of Peripartum Floor Lockdowns on Newborn Safety
The Impact of Peripartum Floor Lockdowns on Newborn Safety Open
Background For the safety of newborns, infrastructural lockdown of peripartum floors may be imperative. Materials and Methods Cumulative data with no identifiers at all was collected from Midas Incident Reporting System reports and Securit…