Devanshi Seth
YOU?
Author Swipe
View article: Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center
Validation of blood phosphatidylethanol as an alcohol consumption biomarker in patients with alcohol use disorder and liver disease at a liver transplant center Open
Background Phosphatidylethanol (PEth), ethyl glucuronide (EtG), and ethyl sulphate (EtS) are highly sensitive and specific biomarkers of alcohol intake. This study investigated their application and relationship to traditional self‐report …
View article: Effects and Diagnostic Approach of Ultrasound in Veterinary Practice: A Systematic Review
Effects and Diagnostic Approach of Ultrasound in Veterinary Practice: A Systematic Review Open
In medicine, ultrasonography is being used more and more for both diagnostic and therapeutic purposes. It is critical that medical professionals and scientists involved in this sector comprehend the biological effects of ultrasound because…
View article: A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry
A polygenic risk score for alcohol-associated cirrhosis among heavy drinkers with European ancestry Open
Background: Polygenic Risk Scores (PRS) based on results from genome-wide association studies offer the prospect of risk stratification for many common and complex diseases. We developed a PRS for alcohol-associated cirrhosis by comparing …
View article: MicroRNAs Signature Panel Identifies Heavy Drinkers with Alcohol-Associated Cirrhosis from Heavy Drinkers without Liver Injury
MicroRNAs Signature Panel Identifies Heavy Drinkers with Alcohol-Associated Cirrhosis from Heavy Drinkers without Liver Injury Open
Background: Alcohol-associated liver disease (ALD) is the most common disorder of prolonged drinking. Mechanisms underlying cirrhosis in such patients remain unclear. MicroRNAs play regulatory role in several diseases, are affected by alco…
View article: MicroRNAs Signature Set Identifies Heavy Drinkers with Alcohol-associated Cirrhosis from those Without Liver Injury
MicroRNAs Signature Set Identifies Heavy Drinkers with Alcohol-associated Cirrhosis from those Without Liver Injury Open
Background: Alcohol-associated Liver Disease (ALD) is the most common disorder of prolonged drinking. Mechanisms underlying cirrhosis in such patients remain unclear. MicroRNAs play regulatory role in several diseases, are affected by alco…
View article: Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish ( <i>Danio rerio</i> )
Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish ( <i>Danio rerio</i> ) Open
Background Accumulation of lipid in the liver is the first hallmark of both alcohol‐related liver disease (ALD) and non‐alcohol‐related fatty liver disease (NAFLD). Recent studies indicate that specific mutations in lipid genes confer risk…
View article: Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (<i>Danio rerio</i>)
Investigating the role of lipid genes in liver disease using fatty liver models of alcohol and high fat in zebrafish (<i>Danio rerio</i>) Open
Background Accumulation of lipid in the liver is the first hallmark of both alcohol-related liver disease (ALD) and non-alcohol-related fatty liver disease (NAFLD). Recent studies indicate that specific mutations in lipid genes confer risk…
View article: All‐cause and liver‐related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank
All‐cause and liver‐related mortality risk factors in excessive drinkers: Analysis of data from the UK biobank Open
Background High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts of alcohol. Methods We obtained information from the UK Biobank on approximately 500…
View article: LIVER-RELATED AND OTHER-CAUSE MORTALITY RISK IN EXCESSIVE DRINKERS: ANALYSIS OF DATA FROM THE UK BIOBANK
LIVER-RELATED AND OTHER-CAUSE MORTALITY RISK IN EXCESSIVE DRINKERS: ANALYSIS OF DATA FROM THE UK BIOBANK Open
Background and Aims High alcohol intake is associated with increased mortality. We aimed to identify factors affecting mortality in people drinking extreme amounts. Approach and Results Information was obtained from the UK Biobank on appro…
View article: Validation of the <scp>aMAP</scp> score to predict hepatocellular carcinoma development in a cohort of alcohol‐related cirrhosis patients
Validation of the <span>aMAP</span> score to predict hepatocellular carcinoma development in a cohort of alcohol‐related cirrhosis patients Open
Background and Aims The aMAP score was recently devised to predict hepatocellular carcinoma (HCC) development. However, its performance was not tested in alcohol‐related cirrhosis (ALC). We aimed to validate the aMAP score in a cohort of A…
View article: IDDF2021-ABS-0137 The aMAP score predicts risk of hepatocellular carcinoma development in patients with alcohol-related cirrhosis
IDDF2021-ABS-0137 The aMAP score predicts risk of hepatocellular carcinoma development in patients with alcohol-related cirrhosis Open
Background The aMAP score (derived from age, male sex, albumin and platelet count) was recently devised to predict hepatocellular carcinoma (HCC) development. It was shown to have excellent performance irrespective of aetiology and ethnici…
View article: MicroRNAs in toxic acute kidney injury: Systematic scoping review of the current status
MicroRNAs in toxic acute kidney injury: Systematic scoping review of the current status Open
Acute kidney injury induced by nephrotoxic agents is common, increasing in incidence and associated with considerable morbidity and mortality in developing countries. MicroRNAs are stable biomarkers that can be detected in extracellular fl…
View article: Alcoholic and non-alcoholic steatohepatitis
Alcoholic and non-alcoholic steatohepatitis Open
This paper is based upon the “Charles Lieber Satellite Symposia” organized by Manuela G. Neuman at the Research Society on Alcoholism (RSA) Annual Meetings, 2013 and 2014. The present review includes pre-clinical, translational and clinica…
View article: Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers
Obesity, Diabetes, Coffee, Tea, and Cannabis Use Alter Risk for Alcohol-Related Cirrhosis in 2 Large Cohorts of High-Risk Drinkers Open
INTRODUCTION: Sustained high alcohol intake is necessary but not sufficient to produce alcohol-related cirrhosis. Identification of risk factors, apart from lifetime alcohol exposure, would assist in discovery of mechanisms and prediction …
View article: Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors
Genome‐wide Association Study and Meta‐analysis on Alcohol‐Associated Liver Cirrhosis Identifies Genetic Risk Factors Open
Background and Aims Only a minority of heavy drinkers progress to alcohol‐associated cirrhosis (ALC). The aim of this study was to identify common genetic variants that underlie risk for ALC. Approach and Results We analyzed data from 1,12…
View article: Second hits exacerbate alcohol-related organ damage: an update
Second hits exacerbate alcohol-related organ damage: an update Open
Chronic and excessive alcohol abuse cause direct and indirect detrimental effects on a wide range of body organs and systems and accounts for ~4% of deaths worldwide. Many factors influence the harmful effects of alcohol. This concise revi…
View article: Genetics of alcohol-related hepatocellular carcinoma - its role in risk prediction
Genetics of alcohol-related hepatocellular carcinoma - its role in risk prediction Open
Hepatocellular carcinoma (HCC) is the most common primary liver malignancy, with increasing incidence worldwide. Alcohol-related cirrhosis (AC) accounts for 30% of the global incidence of HCC and HCC-related deaths. With the decline of hep…
View article: N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research
N-acetyl cysteine in the treatment of alcohol use disorder in patients with liver disease: Rationale for further research Open
NAC is low cost, well-tolerated and could have promise for the treatment of alcohol use disorder in the presence of liver disease. Clinical trials directly examining efficacy in this population are required.
View article: Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis
Circulating Endothelial Progenitor Cells Present an Inflammatory Phenotype and Function in Patients With Alcoholic Liver Cirrhosis Open
Background and Aim: Endothelial progenitor cells (EPCs) have been implicated in liver injury and repair. However, the phenotype and potential of these heterogenous EPCs remain elusive. In particular, their involvement in the pathogenesis o…
View article: Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease
Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease Open
Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, GLI activation can occur independently of the …