Devender Pathak
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View article: AAV gene therapy in hemophilia B shows robust bleeding reduction and variable factor IX expression: A bayesian meta-analysis of randomized controlled trials
AAV gene therapy in hemophilia B shows robust bleeding reduction and variable factor IX expression: A bayesian meta-analysis of randomized controlled trials Open
Introduction Hemophilia B, a congenital X-linked bleeding disorder caused by factor IX (FIX) deficiency, poses significant challenges despite advances in prophylactic factor replacement therapy. Gene therapy, leveraging adeno-associated vi…
View article: Nanomaterial as Diagnostic tool and Drug Carrier
Nanomaterial as Diagnostic tool and Drug Carrier Open
View article: Anti‐<scp>PF4</scp> disorders: Pathogenesis, diagnosis and treatment
Anti‐<span>PF4</span> disorders: Pathogenesis, diagnosis and treatment Open
Summary Platelet factor 4 (PF4) is a cationic protein, able to form complexes with negatively charged molecules upon its self‐assembly into PF4 tetramers. The targeting of these PF4 complexes by immunoglobulin G (IgG) antibodies underlies …
View article: Anti-depressant-Like Effect of Ethanolic Leaves Extract of Anthocephalus cadamba in CUMS Model of Depression in Swiss Albino Mice
Anti-depressant-Like Effect of Ethanolic Leaves Extract of Anthocephalus cadamba in CUMS Model of Depression in Swiss Albino Mice Open
View article: Solvent-dependent phytochemical profiling and DPPH-scavenging activity of Cichorium intybus leaf extracts
Solvent-dependent phytochemical profiling and DPPH-scavenging activity of Cichorium intybus leaf extracts Open
View article: Evaluation of the anxiolytic activity of ethanolic extract of Ziziphus mauritiana Lam. in Swiss albino mice
Evaluation of the anxiolytic activity of ethanolic extract of Ziziphus mauritiana Lam. in Swiss albino mice Open
Background: Ziziphus mauritiana (Rhamnaceae), also known as Ziziphus jujuba Mill is used in traditional Chinese medicine to treat pain, vertigo, amnesia, and sleeplessness. The objective of this research was to examine the anxiolytic prope…
View article: Preparation and evaluation of different herbal gels synthesized from Chinese medicinal plants as an antimicrobial agents
Preparation and evaluation of different herbal gels synthesized from Chinese medicinal plants as an antimicrobial agents Open
Background: The aim of the present study was to formulate and evaluate the herbal gels containing Chinese onion or Allium cepa (A. cepa), Yin Lian Ye or Azadirachta indica (A. indica) and Chinese peppermint or Menthe piperita (M. piperita)…
View article: Pharmacological and therapeutic potential of Hordeum vulgare
Pharmacological and therapeutic potential of Hordeum vulgare Open
Introduction: One of the first grains to be cultivated was Hordeum vulgare, which was grown in the Fertile Crescent, a region of Western Asia near the Nile River in North-East Africa and many other regions like russia, china. It has a lot …
View article: An updated review of Ziziphus jujube: Major focus on its phytochemicals and pharmacological properties
An updated review of Ziziphus jujube: Major focus on its phytochemicals and pharmacological properties Open
Introduction: Ziziphus jujube (ZJ) or Chinese date or Indian ber is one of the extensively studied medicinal plants as it is a rich source of phytochemicals and thus may encourage a healthy diet. It is a medium-sized native plant of the Rh…
View article: CELL LINE STUDIES OF RGD-FBG BASED NANOSCAFFOLDS OF EVEROLIMUS DRUG FOR GLIOBLASTOMAS
CELL LINE STUDIES OF RGD-FBG BASED NANOSCAFFOLDS OF EVEROLIMUS DRUG FOR GLIOBLASTOMAS Open
Aims/Objective: To evaluate and characterized RGD sequenced fibrin/fibrinogen based nanoscaffolds (acid-labile linker) for the treatment of brain tumor targeting using u-87MG cell lines.
View article: Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study
Cardioprotective Potential of Qusqualis indica Leaves; An in silico Docking Study Open
Background: Nowadays cardiac problems are the main cause of death. It includes coronary artery disease, angina pectoris (stable and unstable), congestive heart failure, etc. Objectives: The aim of this paper was to generate scientific data…
View article: Scientific Update on the Pharmacognostic and Pharmacological Properties of Brassica juncea
Scientific Update on the Pharmacognostic and Pharmacological Properties of Brassica juncea Open
Since ancient times, many communities have employed plants to treat a wide range of illnesses, including infections. In underdeveloped and developed countries like, the aforementioned traditional plants serve a essential healthcare require…
View article: Synthesis and biological evaluation of some novel quinoline derivatives bearing pyrazole moiety
Synthesis and biological evaluation of some novel quinoline derivatives bearing pyrazole moiety Open
Reported herein are the design, development and investigation for antibacterial and antifungal studies of a novel series of substituted quinoline analogues bearing pyrazole moiety. Acetanilide derivatives were prepared from the reaction of…
View article: Attenuation of Strychnine-Induced Epilepsy Employing Amaranthus viridis L. Leaves Extract in Experimental Rats
Attenuation of Strychnine-Induced Epilepsy Employing Amaranthus viridis L. Leaves Extract in Experimental Rats Open
Objective. Epilepsy is one of the most prevalent neurological illnesses defined by periodic seizures with or without loss of consciousness caused by aberrant neural activity. There are many allopathic medications available for the treatmen…
View article: Synthesis and Evaluation of Antibacterial and Antifungal profile of some Newer Isoxazole Analogous
Synthesis and Evaluation of Antibacterial and Antifungal profile of some Newer Isoxazole Analogous Open
A new series of 5-(chloromethyl)-3- (substituted phenyl) isoxazole was synthesized in the presence of sodium hydroxide, substituted aromatic aldehyde (1) combine to produce oxime(2), which are then cyclized in the presence of dichlorometha…
View article: Scientific Update on the Pharmacognostic, Pharmacological and Phytochemical Properties of Thevetia peruviana
Scientific Update on the Pharmacognostic, Pharmacological and Phytochemical Properties of Thevetia peruviana Open
View article: Preparation and Evaluation of Different Herbal Gels Synthesized from Chinese Medicinal Plants
Preparation and Evaluation of Different Herbal Gels Synthesized from Chinese Medicinal Plants Open
View article: Telemedicine and Biosensors, A Boon in COVID Era: An Update
Telemedicine and Biosensors, A Boon in COVID Era: An Update Open
Telemedicine means delivery of medical care and provision of general health services from a distance. Telemedicine tools have been evolved for at home COVID-19 diagnosis, screening, monitoring and treatment. Telemedicine has been practiced…
View article: Synthesis, Preliminary Anticonvulsant (Electro-Shock) and Acute Oral Toxicity Screening of Substituted-3-Acetyl-2-(substitutedphenyl)-4-methylbenzo[b][1,4]thiazepin-5(2H)-yl)-1-(substitutedphenyl)propan-1-one
Synthesis, Preliminary Anticonvulsant (Electro-Shock) and Acute Oral Toxicity Screening of Substituted-3-Acetyl-2-(substitutedphenyl)-4-methylbenzo[b][1,4]thiazepin-5(2H)-yl)-1-(substitutedphenyl)propan-1-one Open
The current research aimed to synthesize a novel series of 5-substituted mannich bases using the substitution at 5th position at which the hydrogen atom was replaced by two different substituents, p-nitroacetophenone and p-chloroacetopheno…
View article: Synthesis, Characterization and Biological Evaluation of Novel Isoxazolo [5,4-b] Quinolines as potent Antimicrobial Agents
Synthesis, Characterization and Biological Evaluation of Novel Isoxazolo [5,4-b] Quinolines as potent Antimicrobial Agents Open
In order to combat antimicrobial resistance, antimicrobial chemotherapy made advances in the development of new potent antibiotics and antifungal agents. This is because the microorganisms are becoming resistant to the drugs due to improve…
View article: Synthesis, preliminary anticonvulsant and toxicity screening of substituted 3-(Dimethyl/Diethylamino)-{1-[4-methyl-2-substitutedphenyl-2,5-dihydro-1,5-benzothiazepin-3-yl]}propan-1-one
Synthesis, preliminary anticonvulsant and toxicity screening of substituted 3-(Dimethyl/Diethylamino)-{1-[4-methyl-2-substitutedphenyl-2,5-dihydro-1,5-benzothiazepin-3-yl]}propan-1-one Open
Background; 1,5-benzothiazepine moiety is a very important pharmacophore bioactive compound that exhibits different biological activities. By the literature review the basic structure requirements for anticonvulsant activity contains molec…
View article: Histoenzymic Studies on Localization of Diaphorases and Esterases in Cyclic Corpus Luteum of Indian Buffalo
Histoenzymic Studies on Localization of Diaphorases and Esterases in Cyclic Corpus Luteum of Indian Buffalo Open
The current study was conducted on corpus luteum (CL) from healthy buffalo ovaries (n = 40) collected from local slaughterhouses.The CL was cleaned, observed grossly, and categorized into early luteal (stage I, 1 to 5 days), mid-luteal (st…
View article: Artificial Intelligence‐Based Data‐Driven Strategy to Accelerate Research, Development, and Clinical Trials of COVID Vaccine
Artificial Intelligence‐Based Data‐Driven Strategy to Accelerate Research, Development, and Clinical Trials of COVID Vaccine Open
The global COVID‐19 (coronavirus disease 2019) pandemic, which was caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), has resulted in a significant loss of human life around the world. The SARS‐CoV‐2 has caused sig…
View article: Antidepressive‐Like Effect of <i>Aegle marmelos</i> Leaf Extract in Chronic Unpredictable Mild Stress‐Induced Depression‐Like Behaviour in Rats
Antidepressive‐Like Effect of <i>Aegle marmelos</i> Leaf Extract in Chronic Unpredictable Mild Stress‐Induced Depression‐Like Behaviour in Rats Open
Background . Depression is a psychiatric disorder leading to anhedonia and lack of interest and motivation. Depressive symptoms are triggered by stressful life events, and patients with major depression are at significantly increased risk …
View article: Screening of Anti-Hyperglycaemic and Anti- Hyperlipidemic Activities of Leaves Extracts of Cassia glauca Lam. on Streptozotocin-Nicotinamide Induced NIDDM Rats
Screening of Anti-Hyperglycaemic and Anti- Hyperlipidemic Activities of Leaves Extracts of Cassia glauca Lam. on Streptozotocin-Nicotinamide Induced NIDDM Rats Open
Aim: The objective of the present study was to screen the anti-hyperglycaemic and antihyperlipidemic activities of leaf extracts (Pet-ether, Chloroform, Acetone, and Methanol) of Cassia glauca Lam. on streptozotocin-nicotinamide induced NI…
View article: Evaluation of Anthelmintic Activity of Calendula officinalis Flowers Extract
Evaluation of Anthelmintic Activity of Calendula officinalis Flowers Extract Open
Background: The present study is an attempt to explore the anthelmintic activity of ethanolic extract of flower of Calendula officinalis. Various doses of ethanolic extracts were evaluated for their anthelmintic activity on adult Indian ea…
View article: Design and In silico Studies of 2,5-Disubstituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Pteridine Reductase 1 Inhibitors
Design and In silico Studies of 2,5-Disubstituted 1,2,4-Triazole and 1,3,4-Thiadiazole Derivatives as Pteridine Reductase 1 Inhibitors Open
Aims: Design and in silico studies of 2,5-disubstituted triazole and thiadiazole derivatives as Pteridine Reductase 1 inhibitors. With a view to develop effective agents against Leishmaniasis, 2-substituted-5-[(1H-benzimidazol-2yl) methyl]…
View article: CURRENT UPDATES ON COVID-19 VACCINES
CURRENT UPDATES ON COVID-19 VACCINES Open
Background: COVID-19 caused the world to shut down and made us to critically look out at our advanced healthcare systems that are well prepared for heart diseases, cancers, organ transplantation but not for attack of a tiny virus. WHO and …
View article: Chemoprophylatic, Ayurvedic, Homeopathic Approaches for COVID-19 Prophylaxis
Chemoprophylatic, Ayurvedic, Homeopathic Approaches for COVID-19 Prophylaxis Open
The world is grappling for US FDA-approved therapies for Severe Acute Respiratory Syndrome Corona Virus 2 (SARS-CoV-2). It is the virus that has caused Coronavirus Disease 2019 (COVID-19). Several pharmacological drugs are under various ph…
View article: CONVALESCENT PLASMA THERAPY FOR COVID-19 PATIENTS: REGULATORY GUIDANCE ON COLLECTION, TESTING, PROCESSING, STORAGE, DISTRIBUTION, AND CLINICAL TRIALS
CONVALESCENT PLASMA THERAPY FOR COVID-19 PATIENTS: REGULATORY GUIDANCE ON COLLECTION, TESTING, PROCESSING, STORAGE, DISTRIBUTION, AND CLINICAL TRIALS Open
Convalescent plasma can be transfused to patients suffering from the same infection or for preparing immunoglobulin concentrates. Plasma obtained from recovered patients can be a valuable alternative during the COVID-19 pandemic for suppor…