Devendra K. Agrawal
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View article: Intricate interplay between ORMDL3, ER stress, and autophagy in the diabetic intestine
Intricate interplay between ORMDL3, ER stress, and autophagy in the diabetic intestine Open
Diabetes mellitus (DM) and inflammatory bowel disease (IBD) are prevalent chronic conditions characterized by immune dysregulation and metabolic disturbances. The global incidence of both diseases is increasing, with mounting evidence high…
View article: Sex-based differences in streptozotocin-induced type 2 diabetes rat models
Sex-based differences in streptozotocin-induced type 2 diabetes rat models Open
Background: Diabetic foot ulcers (DFUs) are a severe complication of diabetes mellitus, leading to chronic infections, amputations, and increased mortality despite existing treatments. More effective therapeutics are urgently needed, and a…
View article: Bioprinting for craniofacial reconstruction: A review of advancements, clinical use, and challenges
Bioprinting for craniofacial reconstruction: A review of advancements, clinical use, and challenges Open
Craniofacial reconstructive surgery faces significant challenges due to complex anatomy, intricate vascularization requirements, and the limitations of traditional grafts. Recent advancements in three-dimensional (3D) bioprinting technolog…
View article: Differential Gene Expression in Rheumatoid Arthritis: Implication in the Diagnosis and Individualized Treatment Plan
Differential Gene Expression in Rheumatoid Arthritis: Implication in the Diagnosis and Individualized Treatment Plan Open
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of the joints due to the involvement of biologic, environmental, and genetic factors. Due to its pathogenesis being multifactorial in o…
View article: Outcomes of Rotator Cuff Repair: Open vs. Arthroscopic Approaches in Patients with Diabetes or Hyperlipidemia
Outcomes of Rotator Cuff Repair: Open vs. Arthroscopic Approaches in Patients with Diabetes or Hyperlipidemia Open
Rotator cuff injuries are a common cause of shoulder dysfunction, with diabetes mellitus and hyperlipidemia contributing to increased tendon vulnerability and impaired healing. In this article, a critical evaluation is presented on the com…
View article: Current Strategies in the Prevention and Management of Infection in Open Fractures
Current Strategies in the Prevention and Management of Infection in Open Fractures Open
Open fractures are complex injuries that significantly increase the risk of infection and complications such as delayed healing, nonunion, and chronic osteomyelitis. Infections rates remain high, particularly in severe cases involving exte…
View article: A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine
A New Model of Heart Failure with Preserved Ejection Fraction Induced by Metabolic Syndrome in Ossabaw Miniature Swine Open
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically pre…
View article: A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine
A new model of heart failure with preserved ejection fraction induced by metabolic syndrome in Ossabaw miniature swine Open
A major obstacle to progress in heart failure with preserved ejection fraction (HFpEF) is the paucity of clinically relevant animal models. We developed a large, translationally relevant model in Ossabaw minipigs, which are genetically pre…
View article: Validation of Electromagnetic Field Sensor Performance Through Porcine Skulls: Implications for Neurostimulation and Recording Techniques
Validation of Electromagnetic Field Sensor Performance Through Porcine Skulls: Implications for Neurostimulation and Recording Techniques Open
View article: Surgical interventions in Severe Osteoarthritis: Pros and Cons
Surgical interventions in Severe Osteoarthritis: Pros and Cons Open
Severe osteoarthritis (OA) is a debilitating condition that often necessitates surgical intervention when conservative treatments fail. We carefully reviewed the literature on the pros and cons of surgical options for severe OA, focusing o…
View article: Innovative Approaches for the Treatment of Spinal Disorders: A Comprehensive Review
Innovative Approaches for the Treatment of Spinal Disorders: A Comprehensive Review Open
This comprehensive review explores the latest advancements in the management of spinal disorders, including minimally invasive surgical techniques, treatment of complex deformities, disc replacement technologies, and non-surgical approache…
View article: 14-3-3ζ: an optimal housekeeping protein for western blot analysis in swine rotator cuff tendon studies
14-3-3ζ: an optimal housekeeping protein for western blot analysis in swine rotator cuff tendon studies Open
View article: Advancing Osteoarthritis Research: Insights from Rodent Models and Emerging Trends
Advancing Osteoarthritis Research: Insights from Rodent Models and Emerging Trends Open
Osteoarthritis (OA) is a degenerative joint disease that affects millions of individuals worldwide, causing pain, disability, and a significant burden on public health. Preclinical research using animal models is essential to our understan…
View article: Application of Artificial Intelligence and its Subsets in Various Stages of Knee Arthroplasty from Pre-op to Post-op: An Overview
Application of Artificial Intelligence and its Subsets in Various Stages of Knee Arthroplasty from Pre-op to Post-op: An Overview Open
Osteoarthritis is a complex and painful condition marked by joint destruction and remodeling, often resulting from overuse, aging, or genetic predisposition. Surgical arthroplasty is a widely used treatment to replace degenerated joints, r…
View article: Epidemiology, Pathogenesis, Clinical Manifestations, and Management Strategies of Tuberculous Meningitis
Epidemiology, Pathogenesis, Clinical Manifestations, and Management Strategies of Tuberculous Meningitis Open
Tuberculous meningitis (TBM), the most severe manifestation of extrapulmonary tuberculosis, poses significant global health challenges due to its high mortality rates and complex pathophysiology. This review synthesizes recent findings on …
View article: Nutrition, Gut Microbiota, and Epigenetics in the Modulation of Immune Response and Metabolic Health
Nutrition, Gut Microbiota, and Epigenetics in the Modulation of Immune Response and Metabolic Health Open
Immune system function is intricately shaped by nutritional status, dietary patterns, and gut microbiota composition. Micronutrients such as vitamins A, C, D, E, B-complex, zinc, selenium, iron, and magnesium are critical for maintaining p…
View article: Achilles Tendon Flaps in Lower Extremity Reconstructive Surgery: Versatility, Utility, and Patient-Centered Outcomes
Achilles Tendon Flaps in Lower Extremity Reconstructive Surgery: Versatility, Utility, and Patient-Centered Outcomes Open
Achilles tendon defects represent a challenging reconstructive problem in both athletic and comorbid populations. The objective of this review was to evaluate the versatility, clinical utility, and patient-centered outcomes of Achilles ten…
View article: Predictive Genetic Testing in the Cancer Management and Prevention
Predictive Genetic Testing in the Cancer Management and Prevention Open
View article: Microglial Response to Inflammatory Stimuli Under Electromagnetic Field Exposure
Microglial Response to Inflammatory Stimuli Under Electromagnetic Field Exposure Open
Microglial cells constitute the largest number of non-neuronal cells in the brain. As part of their immune surveillance function, they are responsible for detecting the presence of both external and internal danger signals, stimulating a d…
View article: Isolation of Primary Brain Cells: Challenges and Solutions
Isolation of Primary Brain Cells: Challenges and Solutions Open
The isolation of primary brain cells is essential for studying cellular behavior, signaling pathways, and disease mechanisms in the central nervous system. This paper explores the general and specific steps involved in extracting and cultu…
View article: Neurodevelopmental Risk in HIV-Exposed Uninfected Children: Call for Developmental Surveillance
Neurodevelopmental Risk in HIV-Exposed Uninfected Children: Call for Developmental Surveillance Open
View article: Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health
Role of Gut Microbiota in Long COVID: Impact on Immune Function and Organ System Health Open
SARS-CoV-2 infection has led to a range of long-lasting symptoms, collectively referred to as long COVID. Current research highlights the critical role of angiotensin-converting enzyme 2 (ACE2) in regulating gut microbiota diversity, vascu…
View article: High and Low Dose Ketamine in Post-Traumatic Stress Disorder
High and Low Dose Ketamine in Post-Traumatic Stress Disorder Open
Ketamine has unique properties making it a desirable drug to induce general anesthesia during surgery. However, it is typically reserved for children and adolescent patients due to its side effects in adults, including vivid dreams, halluc…
View article: Long-Term Outcomes of Minimally Invasive vs. Traditional Open Spinal Fusion: A Comparative Analysis
Long-Term Outcomes of Minimally Invasive vs. Traditional Open Spinal Fusion: A Comparative Analysis Open
Spinal fusion is a widely performed surgical intervention for managing degenerative spinal conditions, instability, and deformities. Traditionally, open spinal fusion has been the standard approach, offering direct visualization and access…
View article: Reshaping Anesthesia with Artificial Intelligence: From Concept to Reality
Reshaping Anesthesia with Artificial Intelligence: From Concept to Reality Open
Artificial intelligence (AI) is transforming anesthesiology, showcasing applications that address patient monitoring, closed-loop anesthetic delivery, risk forecasting, customized management, and workflow betterment. This review highlights…
View article: Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation
Bioaerosols and Airway Diseases: Mechanisms of Epithelial Dysfunction, Immune Activation, and Strategies for Exposure Mitigation Open
Bioaerosols-airborne particles of biological origin such as bacteria, fungi, viruses, and allergens-are increasingly recognized as critical environmental factors in the pathogenesis of airway diseases, particularly asthma. This article pro…
View article: Factors Underlying Failure of Methotrexate Treatment in Rheumatoid Arthritis: Implications in Personalized Care
Factors Underlying Failure of Methotrexate Treatment in Rheumatoid Arthritis: Implications in Personalized Care Open
Rheumatoid arthritis (RA) is a chronic inflammatory disease that can be managed with a range of therapeutic treatments. Methotrexate (MTX) is a first-line treatment for RA; however, its metabolism in RA patients can be complicated by multi…
View article: Multimodal Analgesia in the Perioperative Period of Major Surgeries: An In-depth Analysis
Multimodal Analgesia in the Perioperative Period of Major Surgeries: An In-depth Analysis Open
The successful management of postoperative pain remains a significant challenge to patient recovery following high-risk surgeries, often leading to the overuse of opioids and increasing dangers for developing chronic post-surgical pain (CP…
View article: Linking Pathogenesis to Fall Risk in Multiple Sclerosis
Linking Pathogenesis to Fall Risk in Multiple Sclerosis Open
Multiple Sclerosis is a chronic neurological disorder characterized by progressive disability, with falls being a significant consequence of its physical and cognitive impairments. This review explores the major contributors to fall risk i…
View article: CAR T-Cell Therapy in Cancer: Balancing Efficacy with Cardiac Toxicity Concerns
CAR T-Cell Therapy in Cancer: Balancing Efficacy with Cardiac Toxicity Concerns Open
CAR-T therapy (Chimeric antigen receptor T-cell therapy) is a novel and transformative approach to fighting cancer, modulating the immune system involving adoptive cell therapy. In this article, a comprehensive information is provided on t…