Daniel Chandramohan
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View article: The burden of malaria-attributable maternal anemia and the impact of IPTp across sub-Saharan Africa
The burden of malaria-attributable maternal anemia and the impact of IPTp across sub-Saharan Africa Open
Plasmodium falciparum infection during pregnancy is a major contributor to maternal anemia, a leading risk factor for postpartum hemorrhage and maternal death. Yet the scale of malaria-attributable anemia is poorly quantified. We analyzed …
View article: Performance characteristics and potential public health impact of improved pre-erythrocytic malaria vaccines targeting childhood burden
Performance characteristics and potential public health impact of improved pre-erythrocytic malaria vaccines targeting childhood burden Open
New malaria vaccine development builds on groundbreaking recommendations and roll-out of two approved pre-erythrocytic vaccines (PEVs); RTS,S/AS01 and R21/Matrix-M. Whilst these vaccines are effective in reducing childhood malaria within y…
View article: Incidence of Scrub Typhus in Rural South India
Incidence of Scrub Typhus in Rural South India Open
We describe the burden of scrub typhus, including the incidence of asymptomatic infection, in a region of Asia where the disease is endemic. (Funded by the U.K. Medical Research Council; ClinicalTrials.gov number, NCT04506944.).
View article: Educating Health Professions Students About Older Adults: Results From the Age-Friendly Students Senior Connection
Educating Health Professions Students About Older Adults: Results From the Age-Friendly Students Senior Connection Open
Introduction: The Age-Friendly Student Senior Connection (AFSSC) is a graduate-level interprofessional (IP) health student service-learning effort launched early in the COVID-19 pandemic to connect older adults to students providing both s…
View article: Acceptability of the R21/Matrix-M malaria vaccine alongside existing malaria interventions in the trial context
Acceptability of the R21/Matrix-M malaria vaccine alongside existing malaria interventions in the trial context Open
Background The R21/Matrix-M malaria vaccine has been shown to provide high protective efficacy against malaria in a phase III trial, and has been recommended for use by WHO. The vaccine will soon be deployed at scale in sub-Saharan Africa.…
View article: Risk factors for scrub typhus infection in South India: population-based cohort study
Risk factors for scrub typhus infection in South India: population-based cohort study Open
Scrub typhus is a mite-borne infection, largely affecting rural populations in many parts of Asia. This cohort study explored socio-demographic, behavioural, and spatial risk factors at different levels of endemicity. 2206 rural residents …
View article: Community case management to accelerate access to healthcare in Mali: a realist process evaluation nested within a cluster randomized trial
Community case management to accelerate access to healthcare in Mali: a realist process evaluation nested within a cluster randomized trial Open
The Proactive Community Case Management (ProCCM) trial in Mali reinforced the health system across both arms with user fee removal, professional community health workers (CHWs) and upgraded primary health centres (PHCs)—and randomized vill…
View article: Seasonal vaccination with RTS,S/AS01E vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial
Seasonal vaccination with RTS,S/AS01E vaccine with or without seasonal malaria chemoprevention in children up to the age of 5 years in Burkina Faso and Mali: a double-blind, randomised, controlled, phase 3 trial Open
For the French translation of the abstract see Supplementary Materials section.
View article: SD-Bioline Malaria Rapid Diagnostic Test Performance and Time to Become Negative After Treatment of Malaria Infection in Southwest Nigerian Children
SD-Bioline Malaria Rapid Diagnostic Test Performance and Time to Become Negative After Treatment of Malaria Infection in Southwest Nigerian Children Open
Context and Aim: Given the challenges of microscopy, we compared its performance with SD-Bioline malaria rapid diagnostic test (MRDT) and polymerase chain reaction (PCR) and evaluated the time it took for positive results to become negativ…
View article: Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis
Prevalence of and risk factors for microscopic and submicroscopic malaria infections in pregnancy: a systematic review and meta-analysis Open
Bill & Melinda Gates Foundation through the Worldwide Antimalarial Resistance Network.
View article: Coinfections of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review and individual participant data meta-analysis protocol
Coinfections of malaria and sexually transmitted and reproductive tract infections in pregnancy in sub-Saharan Africa: a systematic review and individual participant data meta-analysis protocol Open
Introduction Malaria infection and curable sexually transmitted infections and reproductive tract infections (STIs/RTIs) adversely impact pregnancy outcomes. In sub-Saharan Africa, the prevalence of malaria and curable STIs/RTIs is high an…
View article: Delivery strategies for malaria vaccination in areas with seasonal malaria transmission
Delivery strategies for malaria vaccination in areas with seasonal malaria transmission Open
Background Seasonal vaccination with the RTS,S/AS01 E malaria vaccine given alongside seasonal malaria chemoprevention (SMC) substantially reduces malaria in young children. The WHO has recommended the use of RTS,S/AS01 E , including seaso…
View article: Effects of proactive vs fixed community health care delivery on child health and access to care: a cluster randomised trial secondary endpoint analysis
Effects of proactive vs fixed community health care delivery on child health and access to care: a cluster randomised trial secondary endpoint analysis Open
ClinicalTrials.gov NCT02694055.
View article: Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death
Effect of Intrapartum Azithromycin vs Placebo on Neonatal Sepsis and Death Open
Importance Neonatal sepsis is a leading cause of neonatal mortality. New interventions are needed to decrease neonatal sepsis and mortality in regions with highest burden. Objective To evaluate the efficacy of intrapartum azithromycin to r…
View article: Seasonal use case for the RTS,S/AS01 malaria vaccine: a mathematical modelling study
Seasonal use case for the RTS,S/AS01 malaria vaccine: a mathematical modelling study Open
UK Medical Research Council, UK Foreign Commonwealth & Development Office, The Wellcome Trust, and The Royal society.
View article: Global estimates of pregnancies at risk of Plasmodium falciparum and Plasmodium vivax infection in 2020 and changes in risk patterns since 2000
Global estimates of pregnancies at risk of Plasmodium falciparum and Plasmodium vivax infection in 2020 and changes in risk patterns since 2000 Open
Background Women are at risk of severe adverse pregnancy outcomes attributable to Plasmodium spp . infection in malaria-endemic areas. Malaria control efforts since 2000 have aimed to reduce this burden of disease. Methods We used data fro…
View article: The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone
The duration of protection against clinical malaria provided by the combination of seasonal RTS,S/AS01E vaccination and seasonal malaria chemoprevention versus either intervention given alone Open
Background A recent trial of 5920 children in Burkina Faso and Mali showed that the combination of seasonal vaccination with the RTS,S/AS01 E malaria vaccine (primary series and two seasonal boosters) and seasonal malaria chemoprevention (…
View article: The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana
The prevalence of molecular markers of resistance to sulfadoxine-pyrimethamine among pregnant women at first antenatal clinic attendance and delivery in the forest-savannah area of Ghana Open
Intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine (IPTp-SP) is used to prevent malaria and associated unfavorable maternal and foetal outcomes in pregnancy in moderate to high malaria transmission areas. Eff…
View article: Resurgent and delayed malaria
Resurgent and delayed malaria Open
The populations of moderate or highly malaria endemic areas gradually acquire some immunity to malaria as a result of repeated exposure to the infection. When this exposure is reduced as a result of effective malaria control measures, subj…
View article: The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine
The Anti-Circumsporozoite Antibody Response of Children to Seasonal Vaccination With the RTS,S/AS01E Malaria Vaccine Open
Background A trial in African children showed that combining seasonal vaccination with the RTS,S/AS01E vaccine with seasonal malaria chemoprevention reduced the incidence of uncomplicated and severe malaria compared with either interventio…
View article: Estimating causes of death where there is no medical certification: evolution and state of the art of verbal autopsy
Estimating causes of death where there is no medical certification: evolution and state of the art of verbal autopsy Open
Over the past 70 years, significant advances have been made in determining the causes of death in populations not served by official medical certification of cause at the time of death using a technique known as Verbal Autopsy (VA). VA inv…
View article: Intermittent screening and treatment with artemisinin-combination therapy versus intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria in pregnancy: a systematic review and individual participant data meta-analysis of randomised clinical trials
Intermittent screening and treatment with artemisinin-combination therapy versus intermittent preventive treatment with sulphadoxine-pyrimethamine for malaria in pregnancy: a systematic review and individual participant data meta-analysis of randomised clinical trials Open
Centers for Disease Control and Prevention and Worldwide Antimalarial Resistance Network.
View article: Impact of mass administration of azithromycin as a preventive treatment on the prevalence and resistance of nasopharyngeal carriage of Staphylococcus aureus
Impact of mass administration of azithromycin as a preventive treatment on the prevalence and resistance of nasopharyngeal carriage of Staphylococcus aureus Open
Staphylococcus aureus is a major cause of serious illness and death in children, indicating the need to monitor prevalent strains, particularly in the vulnerable pediatric population. Nasal carriage of S . aureus is important as carriers h…
View article: EPIDEMIOLOGY OF HEAD INJURY - A LEVEL 1 TAEI CENTRE STUDY
EPIDEMIOLOGY OF HEAD INJURY - A LEVEL 1 TAEI CENTRE STUDY Open
Head injury affects over 60 million people every year which causes mortality and morbidity. Of all the injuries, head injury accounts for most cases of death and disability. Sixty-nine million individuals worldwide suffered from head injur…