Devika M. Varma
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View article: Discovery of Host-Directed Small Molecules with Broad Anti-Leishmanial Efficacy
Discovery of Host-Directed Small Molecules with Broad Anti-Leishmanial Efficacy Open
Leishmaniasis, a neglected tropical disease affecting nearly 10% of the global population, suffers from limited therapeutic options and rising drug resistance. To address this, we developed 343 analogs of AR-12, a compound that has previou…
View article: Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine
Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine Open
Influenza virus is a major cause of death on a global scale. Seasonal vaccines have been developed to combat influenza; however, they are not always highly effective. One strategy to develop a more broadly active influenza vaccine is the u…
View article: 885. Integrated Blood Culture and Molecular Diagnostic Device Reduces Time-to-Result to a Quarter of Traditional Methods
885. Integrated Blood Culture and Molecular Diagnostic Device Reduces Time-to-Result to a Quarter of Traditional Methods Open
Background Prolonged antibiotic exposure in infants with negative blood cultures is associated with adverse outcomes, disruption of the developing microbiome, and increased carriage of antibiotic resistance genes. However, early administra…
View article: Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine
Development of an Intranasal Gel for the Delivery of a Broadly Acting Subunit Influenza Vaccine Open
Intranasal immunization of mice using COBRA H1 with stimulator of interferon genes (STING)-cGAMP gel formulation against influenza.
View article: Overcoming reduced antibiotic susceptibility in intracellular<i>Salmonella enterica</i>serovar Typhimurium using AR-12
Overcoming reduced antibiotic susceptibility in intracellular<i>Salmonella enterica</i>serovar Typhimurium using AR-12 Open
Host-directed therapies (HDTs) could enhance the activity of traditional antibiotics. AR-12 is a promising HDT against intracellular pathogens including Salmonella enterica serovar Typhimurium, and has been shown to act through modulation …
View article: Nano- and Microformulations to Advance Therapies for Visceral Leishmaniasis
Nano- and Microformulations to Advance Therapies for Visceral Leishmaniasis Open
Visceral leishmaniasis (VL) is a deadly, vector-borne, neglected tropical disease endemic to arid parts of the world and is caused by a protozoan parasite of the genus Leishmania. Chemotherapy is the primary treatment for this syste…
View article: Formulation of host-targeted therapeutics against bacterial infections
Formulation of host-targeted therapeutics against bacterial infections Open
View article: Injectable cellulose-based hydrogels as nucleus pulposus replacements: Assessment of in vitro structural stability, ex vivo herniation risk, and in vivo biocompatibility
Injectable cellulose-based hydrogels as nucleus pulposus replacements: Assessment of in vitro structural stability, ex vivo herniation risk, and in vivo biocompatibility Open
View article: Injectable, redox-polymerized carboxymethylcellulose hydrogels promote nucleus pulposus-like extracellular matrix elaboration by human MSCs in a cell density-dependent manner
Injectable, redox-polymerized carboxymethylcellulose hydrogels promote nucleus pulposus-like extracellular matrix elaboration by human MSCs in a cell density-dependent manner Open
Low back pain is a major cause for disability and is closely linked to intervertebral disc degeneration. Mechanical and biological dysfunction of the nucleus pulposus in the disc has been found to initiate intradiscal degenerative processe…
View article: Thermoresponsive, redox-polymerized cellulosic hydrogels undergo in situ gelation and restore intervertebral disc biomechanics post discectomy
Thermoresponsive, redox-polymerized cellulosic hydrogels undergo in situ gelation and restore intervertebral disc biomechanics post discectomy Open
Back and neck pain are commonly associated with intervertebral disc (IVD) degeneration. Structural augmentation of diseased nucleus pulposus (NP) tissue with biomaterials could restore degeneration-related IVD height loss and degraded biom…