Devika P. Bagchi
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View article: Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients
Comparative analysis of plasma and bone marrow nutrient levels in pediatric B-ALL patients Open
Nutrient availability in the tumor microenvironment is a key determinant of cancer progression and therapeutic response, yet the physiological nutrient environment for most cancers is poorly understood. In this study, we investigated nutri…
View article: Effects of β-catenin deficiency on adipose tissue physiology
Effects of β-catenin deficiency on adipose tissue physiology Open
Our studies demonstrate the importance of adipocyte Wnt signaling for regulation of lipid and mitochondrial metabolic processes in stromal-vascular cells and adipocytes in adipose tissues. This research provides further support for an inte…
View article: 1652. Impact of the 2022-2023 Amoxicillin Shortage on Antibiotic Prescribing for Acute Otitis Media: A Regression Discontinuity Study
1652. Impact of the 2022-2023 Amoxicillin Shortage on Antibiotic Prescribing for Acute Otitis Media: A Regression Discontinuity Study Open
Background On October 28th, 2022, the U.S. Food and Drug Administration (FDA) announced a national shortage of amoxicillin powder for liquid suspension. The extent to which drug shortages affect prescribing patterns has been poorly describ…
View article: Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity
Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity Open
Human genome-wide association studies found single-nucleotide polymorphisms (SNPs) near LYPLAL1 (Lysophospholipase-like protein 1) that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLA…
View article: Constitutive bone marrow adipocytes suppress local bone formation
Constitutive bone marrow adipocytes suppress local bone formation Open
BM adipocytes (BMAd) are a unique cell population derived from BM mesenchymal progenitors and marrow adipogenic lineage precursors. Although they have long been considered to be a space filler within bone cavities, recent studies have reve…
View article: Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits Open
To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, Pnpla2 gene). BMAd- Pnpla2 -/- mice have impaired BM…
View article: Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits
Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits Open
Summary To investigate roles for bone marrow adipocyte (BMAd) lipolysis in bone homeostasis, we created a BMAd-specific Cre mouse model in which we knocked out adipose triglyceride lipase (ATGL, Pnpla2 ). BMAd- Pnpla2 -/- mice have impaire…
View article: Knockout of murine <i>Lyplal1</i> confers sex-specific protection against diet-induced obesity
Knockout of murine <i>Lyplal1</i> confers sex-specific protection against diet-induced obesity Open
Human genome-wide association studies found SNPs near LYPLAL1 that have sex-specific effects on fat distribution and metabolic traits. To determine whether altering LYPLAL1 affects obesity and metabolic disease we created and characterized…
View article: Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2 Open
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate function of lamin A/C in adipose tissues, we created mice with an adipocyte-specific loss o…
View article: Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions
Wnt Signaling: From Mesenchymal Cell Fate to Lipogenesis and Other Mature Adipocyte Functions Open
Wnt signaling is an ancient and evolutionarily conserved pathway with fundamental roles in the development of adipose tissues. Roles of this pathway in mesenchymal stem cell fate determination and differentiation have been extensively stud…
View article: Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2 Open
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate function of lamin A/C in adipose tissues, we created mice with an adipocyte-specific loss o…
View article: Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2 Open
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate function of lamin A/C in adipose tissues, we created mice with an adipocyte-specific loss o…
View article: Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2
Adipocyte-Specific Deletion of Lamin A/C Largely Models Human Familial Partial Lipodystrophy Type 2 Open
Mechanisms by which autosomal recessive mutations in Lmna cause familial partial lipodystrophy type 2 (FPLD2) are poorly understood. To investigate the function of lamin A/C in adipose tissue, we created mice with an adipocyte-specific los…
View article: The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures
The molecular and metabolic program by which white adipocytes adapt to cool physiologic temperatures Open
Although visceral adipocytes located within the body’s central core are maintained at approximately 37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell and generally exist at…
View article: Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity Open
Mice lacking SH2B1 and humans with inactivating mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four kno…
View article: Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity Open
Mice lacking SH2B1 and humans with inactivating mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four kno…
View article: Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity
Deletion of the Brain-Specific α and δ Isoforms of Adapter Protein SH2B1 Protects Mice From Obesity Open
Mice lacking SH2B1 and humans with variants of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four known alternative…
View article: Deletion of the brain-specific α and δ isoforms of adapter protein SH2B1 protects mice from obesity
Deletion of the brain-specific α and δ isoforms of adapter protein SH2B1 protects mice from obesity Open
Mice lacking SH2B1 and humans with inactivating mutations of SH2B1 display severe obesity and insulin resistance. SH2B1 is an adapter protein that is recruited to the receptors of multiple hormones and neurotrophic factors. Of the four kno…
View article: The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures
The molecular and metabolic program for adaptation of white adipocytes to cool physiologic temperatures Open
Although visceral adipocytes located within the body’s central core are maintained at ~37°C, adipocytes within bone marrow, subcutaneous, and dermal depots are found primarily within the peripheral shell, and generally exist at cooler temp…
View article: Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction
Wntless regulates lipogenic gene expression in adipocytes and protects against diet-induced metabolic dysfunction Open
Taken together, these studies demonstrate that adipocyte-derived Wnts regulate de novo lipogenesis and lipid desaturation and coordinate the expression of lipogenic genes in adipose tissues. In addition, we report that Wnt signaling within…
View article: Investigating the Roles of Wnt Signaling in Mature Adipocyte Function
Investigating the Roles of Wnt Signaling in Mature Adipocyte Function Open
Obesity is a key risk factor for many secondary chronic illnesses, including type 2 diabetes and cardiovascular disease. Canonical Wnt/β-catenin signaling is well-established as an important regulator of mesenchymal cell fate determination…
View article: The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation
The transcription factor NKX1-2 promotes adipogenesis and may contribute to a balance between adipocyte and osteoblast differentiation Open
Although adipogenesis is mainly controlled by a small number of master transcription factors, including CCAAT/enhancer-binding protein family members and peroxisome proliferator-activated receptor γ (PPARγ), other transcription factors als…
View article: Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring
Lactational High-Fat Diet Exposure Programs Metabolic Inflammation and Bone Marrow Adiposity in Male Offspring Open
Overnutrition during critical windows of development plays a significant role in life-long metabolic disease risk. Early exposure to excessive nutrition may result in altered programming leading to increased susceptibility to obesity, infl…
View article: G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche
G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche Open
Bariatric surgeries are integral to the management of obesity and its metabolic complications. However, these surgeries cause bone loss and increase fracture risk through poorly understood mechanisms. In a mouse model, vertical sleeve gast…