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View article: Walsh coefficients and circuits for several alleles
Walsh coefficients and circuits for several alleles Open
Walsh coefficients have been applied extensively to biallelic systems for quantifying pairwise and higher order epistasis, in particular for demonstrating the empirical importance of higher order interactions. Circuits, or minimal dependen…
View article: A Primer for the Walsh Transform
A Primer for the Walsh Transform Open
A mathematical development of the Walsh transform, Walsh basis, and Walsh coefficients is given. The author was prompted to write this by a wish to give a unified treatment of epistatic coordinates as they are used in evolutionary biology.…
View article: Inferring genetic interactions from comparative fitness data
Inferring genetic interactions from comparative fitness data Open
Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative tools to make inferences about epistati…
View article: Inferring Genetic Interactions From Comparative Fitness Data
Inferring Genetic Interactions From Comparative Fitness Data Open
A bstract Darwinian fitness is a central concept in evolutionary biology. In practice, however, it is hardly possible to measure fitness for all genotypes in a natural population. Here, we present quantitative tools to make inferences abou…
View article: Rational Design of Antibiotic Treatment Plans: A Treatment Strategy for Managing Evolution and Reversing Resistance
Rational Design of Antibiotic Treatment Plans: A Treatment Strategy for Managing Evolution and Reversing Resistance Open
The development of reliable methods for restoring susceptibility after antibiotic resistance arises has proven elusive. A greater understanding of the relationship between antibiotic administration and the evolution of resistance is key to…