Devin Harrison
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View article: Mechanosensitive Endothelial METTL7A Regulates Internal m<sup>7</sup>G mRNA Methylation and Protects Against Atherosclerosis
Mechanosensitive Endothelial METTL7A Regulates Internal m<sup>7</sup>G mRNA Methylation and Protects Against Atherosclerosis Open
BACKGROUND Internal N 7 -methylguanosine (m 7 G) is a recently identified chemical modification of mammalian mRNA and a component of the epitranscriptome. While the epitranscriptome plays a key role in regulating RNA metabolism and cellula…
View article: Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation
Behavioral analysis through the lifespan of disc1 mutant zebrafish identifies defects in sensorimotor transformation Open
DISC1 is a genetic risk factor for multiple psychiatric disorders. Compared to the dozens of murine Disc1 models, there is a paucity of zebrafish disc1 models-an organism amenable to high-throughput experimentation. We…
View article: Top2a promotes the development of social behavior via PRC2 and H3K27me3
Top2a promotes the development of social behavior via PRC2 and H3K27me3 Open
Little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lasting social deficits in zebrafish. In mice, prenatal Top2 inhib…
View article: Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice with Type 2 Diabetes Mellitus
Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice with Type 2 Diabetes Mellitus Open
Hypoxia-inducible factors (HIFs) are the master regulators of angiogenesis, a process that is impaired in patients with diabetes mellitus (DM).The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HIF…
View article: Targeted polyelectrolyte complex micelles treat vascular complications in vivo
Targeted polyelectrolyte complex micelles treat vascular complications in vivo Open
Significance Vascular disease is a leading cause of human morbidity and mortality and current therapies mainly target systemic risk factors but not the diseased vasculature per se. We have devised a targeted nanomedicine approach engineeri…
View article: Top2a promotes the development of social behavior via PRC2 and H3K27me3
Top2a promotes the development of social behavior via PRC2 and H3K27me3 Open
Human infants exhibit innate social behaviors at birth, yet little is understood about the embryonic development of sociality. We screened 1120 known drugs and found that embryonic inhibition of topoisomerase IIα (Top2a) resulted in lastin…
View article: Single-cell lactate production rate as a measure of glycolysis in endothelial cells
Single-cell lactate production rate as a measure of glycolysis in endothelial cells Open
View article: Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus
Endothelial Aryl Hydrocarbon Receptor Nuclear Translocator Mediates the Angiogenic Response to Peripheral Ischemia in Mice With Type 2 Diabetes Mellitus Open
Hypoxia-inducible factors (HIFs) are the master regulators of angiogenesis, a process that is impaired in patients with diabetes mellitus (DM). The transcription factor aryl hydrocarbon receptor nuclear translocator (ARNT, also known as HI…
View article: Human aortic endothelial cell ground truth dataset
Human aortic endothelial cell ground truth dataset Open
Ground truth dataset of human aortic endothelial cells expressing Laconic (GFP channel) and stained with Hoechst (nuclei).
View article: Human aortic endothelial cell ground truth dataset
Human aortic endothelial cell ground truth dataset Open
Ground truth dataset of human aortic endothelial cells expressing Laconic (GFP channel) and stained with Hoechst (nuclei).
View article: Human aortic endothelial cell ground truth dataset
Human aortic endothelial cell ground truth dataset Open
Ground truth dataset of human aortic endothelial cells expressing Laconic (GFP channel) and stained with Hoechst (nuclei).
View article: Human aortic endothelial cell ground truth dataset
Human aortic endothelial cell ground truth dataset Open
Ground truth dataset of human aortic endothelial cells expressing Laconic (GFP channel) and stained with Hoechst (nuclei).
View article: Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells Open
View article: Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells
Single-cell metabolic imaging reveals a SLC2A3-dependent glycolytic burst in motile endothelial cells Open
Single cell imaging data
View article: Single-cell metabolic imaging reveals a RhoA-triggered glycolytic burst in motile endothelial cells
Single-cell metabolic imaging reveals a RhoA-triggered glycolytic burst in motile endothelial cells Open
Single-cell motility is spatially heterogeneous and driven by metabolic energy. Direct linking cell mobility to cell metabolism is technically challenging but biologically important. Here we implemented a single-cell metabolic imaging assa…
View article: T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation
T-Cell Mechanobiology: Force Sensation, Potentiation, and Translation Open
A T cell is a sensitive self-referential mechanical sensor. Mechanical forces influence the recognition, activation, differentiation, and function throughout the lifetime of a T cell. T cells constantly perceive and respond to physical sti…
View article: Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics
Genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics Open
Biomechanical cues dynamically control major cellular processes, but whether genetic variants actively participate in mechanosensing mechanisms remains unexplored. Vascular homeostasis is tightly regulated by hemodynamics. Exposure to dist…
View article: A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics
A genetic variant at coronary artery disease and ischemic stroke locus 1p32.2 regulates endothelial responses to hemodynamics Open
Biomechanical cues dynamically control major cellular processes but whether genetic variants actively participate in mechano-sensing mechanisms remains unexplored. Vascular homeostasis is tightly regulated by hemodynamics. Exposure to dist…
View article: Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells
Antigen-Presenting Cell-Intrinsic PD-1 Neutralizes PD-L1 in cis to Attenuate PD-1 Signaling in T Cells Open
The PD-1 pathway, consisting of the co-inhibitory receptor PD-1 on T cells and its ligand (PD-L1) on antigen-presenting cells (APCs), is a major mechanism of tumor immune evasion. PD-1 and PD-L1 blockade antibodies have produced remarkable…
View article: Cisplatin Analogs Confer Protection against Cyanide Poisoning
Cisplatin Analogs Confer Protection against Cyanide Poisoning Open
View article: Spatially-Resolved Fluorescence Lifetime Measurement for Optical Interrogation of Electrically Dynamic Biological Systems
Spatially-Resolved Fluorescence Lifetime Measurement for Optical Interrogation of Electrically Dynamic Biological Systems Open