Devin Wood
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Scalable Transannular Bromocyclization Approach to Function-alized Bis-Heterobicyclo[3.n.1]anes Open
Bicyclic, high fraction sp3 (Fsp3) building blocks have become prominent in drug discovery efforts due to the potential for improvement in physicochemical properties. As a result, methods to generate bicyclic rings have flourished in recen…
Co-Catalyzed Hydrofluorination of Alkenes: Photocatalytic Method Development and Electroanalytical Mechanistic Investigation Open
The hydrofluorination of alkenes represents an attractive strategy for the synthesis of aliphatic fluorides. This approach provides a direct means to form C(sp3)-F bonds selectively from readily available alkenes. Nonetheless, conducting h…
Deuterodehalogenation Under Net Reductive or Redox‐Neutral Conditions Enabled by Paired Electrolysis Open
Interest in deuterated active pharmaceutical ingredients (APIs) is increasing as deuteration holds promise for kinetic isotope effect (KIE) regulated fine‐tuning of API performance. Moreover, deuterium isotope labeling is frequently carrie…
Deuterodehalogenation Under Net Reductive or Redox-Neutral Conditions Enabled by Paired Electrolysis Open
Interest in deuterated de novo active pharmaceutical ingredients (APIs) is increasing due to the release of the first FDA approved deuterated drug, deutetrabenazine. Deuteration also holds promise for kinetic isotope effect (KIE) regulated…
Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides Open
Herein a bimetallic radical redox-relay strategy is employed to generate alkyl radicals under mild conditions with titanium(III) catalysis and terminated via hydrogen atom transfer with cobalt(II) catalysis to enact base-free isomerization…
Primary Data for Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides Open
1H and 13C spectra primary data for Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides. Spectra were recorded on Inova-400 (400 MHz), Inova-500 (500 MHz), and Inova-600 (600 MHz) s…
Primary Data for Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides Open
1H and 13C spectra primary data for Titanium and Cobalt Bimetallic Radical Redox Relay for the Isomerization of N-Bz Aziridines to Allylic Amides. Spectra were recorded on Inova-400 (400 MHz), Inova-500 (500 MHz), and Inova-600 (600 MHz) s…
New Redox Strategies in Organic Synthesis by Means of Electrochemistry and Photochemistry Open
As the breadth of radical chemistry grows, new means to promote and regulate single-electron redox activities play increasingly important roles in driving modern synthetic innovation. In this regard, photochemistry and electrochemistry-bot…