Devishree Krishnan
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View article: Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect
Deficiency of Carbonic Anhydrase II Results in a Urinary Concentrating Defect Open
Carbonic anhydrase II (CAII) is expressed along the nephron where it interacts with a number of transport proteins augmenting their activity. Aquaporin-1 (AQP1) interacts with CAII to increase water flux through the water channel. Both CAI…
View article: Renal proximal tubular reabsorption of sodium, water and calcium are interconnected
Renal proximal tubular reabsorption of sodium, water and calcium are interconnected Open
Intravascular volume is maintained by complex interplay between organ systems with a main role for renal sodium, and water handling. The glomerulus filters a large quantity of water and salt daily with the majority of sodium, water and cal…
View article: Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3
Carbonic anhydrase II binds to and increases the activity of the epithelial sodium-proton exchanger, NHE3 Open
Two-thirds of sodium filtered by the renal glomerulus is reabsorbed from the proximal tubule via a sodium/proton exchanger isoform 3 (NHE3)-dependent mechanism. Since sodium and bicarbonate reabsorption are coupled, we postulated that the …
View article: Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction
Increased water flux induced by an aquaporin-1/carbonic anhydrase II interaction Open
Aquaporin-1 (AQP1) enables greatly enhanced water flux across plasma membranes. The cytosolic carboxy terminus of AQP1 has two acidic motifs homologous to known carbonic anhydrase II (CAII) binding sequences. CAII colocalizes with AQP1 in …