Devon Van Cura
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View article: Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation
Chemical capture of diazo metabolites reveals biosynthetic hydrazone oxidation Open
Chemically reactive microbial natural products have enabled therapeutic development 1,2 via their well-established bioactivities including anticancer, 3 antibiotic, 4,5 and antioxidant 6 activities. However, discovery of reactive metabolit…
View article: Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α‐Diazoester Production
Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α‐Diazoester Production Open
Azaserine is a bacterial metabolite containing a biologically unusual and synthetically enabling α‐diazoester functional group. Herein, we report the discovery of the azaserine ( aza ) biosynthetic gene cluster from Glycomyces harbinensis …
View article: Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α‐Diazoester Production
Discovery of the Azaserine Biosynthetic Pathway Uncovers a Biological Route for α‐Diazoester Production Open
Azaserine is a bacterial metabolite containing a biologically unusual and synthetically enabling α‐diazoester functional group. Herein, we report the discovery of the azaserine ( aza ) biosynthetic gene cluster from Glycomyces harbinensis …
View article: Complete integration of carbene-transfer chemistry into biosynthesis
Complete integration of carbene-transfer chemistry into biosynthesis Open
Biosynthesis is an environmentally benign and renewable approach that can be used to produce a broad range of natural and, in some cases, new-to-nature products. However, biology lacks many of the reactions that are available to synthetic …
View article: Substrate-Triggered Formation of a Peroxo-Fe<sub>2</sub>(III/III) Intermediate during Fatty Acid Decarboxylation by UndA
Substrate-Triggered Formation of a Peroxo-Fe<sub>2</sub>(III/III) Intermediate during Fatty Acid Decarboxylation by UndA Open
The iron-dependent oxidase UndA cleaves one C3-H bond and the C1-C2 bond of dodecanoic acid to produce 1-undecene and CO2. A published X-ray crystal structure showed that UndA has a heme-oxygenase-like fold, thus associating it with a stru…