Devon Kavanaugh
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View article: Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut
Targeting sialic acid catabolism with polyvalent sialidase inhibitors to mitigate bacterial inflammation in the gut Open
Inflammatory bowel diseases (IBD), including Crohn's disease and ulcerative colitis, are chronic inflammatory disorders strongly associated with intestinal dysbiosis and the overgrowth of pro-inflammatory Enterobacteriaceae. A key driver o…
View article: Vat-Mediated Mucus Penetration Enables Genotoxic Activity of pks+ Escherichia coli
Vat-Mediated Mucus Penetration Enables Genotoxic Activity of pks+ Escherichia coli Open
Colibactin toxin-producing Escherichia coli (pks+ E. coli) strains are associated with the occurrence of colorectal cancer in humans. These strains induce DNA damage when in close contact with the cells of the intestinal epithelium. Theref…
View article: Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella
Biochemical characterization of the Escherichia coli surfaceome: a focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella
Biochemical characterization of the<i>Escherichia coli</i>surfaceome: A focus on type I fimbriae and flagella Open
The Escherichia coli surfaceome consists mainly of the large surface organelles expressed by the organism to navigate and interact with the surrounding environment. The current study focuses on type I fimbriae and flagella. These large pol…
View article: Identification of a New Pathogenicity Island Within the Large pAH187_270 Plasmid Involved in Bacillus cereus Virulence
Identification of a New Pathogenicity Island Within the Large pAH187_270 Plasmid Involved in Bacillus cereus Virulence Open
Objectives Bacillus cereus is responsible for food poisoning and rare but severe clinical infections. The pathogenicity of B. cereus strains varies from harmless to lethal strains. The objective of this study was to characterize three B. c…
View article: The pathogenic biomarker alcohol dehydrogenase protein is involved in Bacillus cereus virulence and survival against host innate defence
The pathogenic biomarker alcohol dehydrogenase protein is involved in Bacillus cereus virulence and survival against host innate defence Open
Bacillus cereus is a spore forming bacteria recognized among the leading agents responsible for foodborne outbreaks in Europe. B . cereus is also gaining notoriety as an opportunistic human pathogen inducing local and systemic infections. …
View article: New genetic biomarkers to differentiate non-pathogenic from clinically relevant Bacillus cereus strains
New genetic biomarkers to differentiate non-pathogenic from clinically relevant Bacillus cereus strains Open
View article: Sensitive Detection of E. coli in Artificial Seawater by Aptamer-Coated Magnetic Beads and Direct PCR
Sensitive Detection of E. coli in Artificial Seawater by Aptamer-Coated Magnetic Beads and Direct PCR Open
The ‘One Health’ approach recommended by WHO recognizes the inseparable link between human, animal and environmental health [...]
View article: Point-of-Need DNA Testing for Detection of Foodborne Pathogenic Bacteria
Point-of-Need DNA Testing for Detection of Foodborne Pathogenic Bacteria Open
Foodborne pathogenic bacteria present a crucial food safety issue. Conventional diagnostic methods are time-consuming and can be only performed on previously produced food. The advancing field of point-of-need diagnostic devices integratin…
View article: Serine-rich repeat protein adhesins from<i>Lactobacillus reuteri</i>display strain specific glycosylation profiles
Serine-rich repeat protein adhesins from<i>Lactobacillus reuteri</i>display strain specific glycosylation profiles Open
Lactobacillus reuteri is a gut symbiont inhabiting the gastrointestinal tract of numerous vertebrates. The surface-exposed serine-rich repeat protein (SRRP) is a major adhesin in Gram-positive bacteria. Using lectin and sugar nucleotide pr…
View article: Structural basis for the role of serine-rich repeat proteins from <i>Lactobacillus reuteri</i> in gut microbe–host interactions
Structural basis for the role of serine-rich repeat proteins from <i>Lactobacillus reuteri</i> in gut microbe–host interactions Open
Significance Gut bacteria play a key role in health and disease, but the molecular mechanisms underpinning their interaction with the host remain elusive. The serine-rich repeat proteins (SRRPs) are a family of adhesins identified in many …
View article: Molecular basis for intestinal mucin recognition by galectin‐3 and C‐type lectins
Molecular basis for intestinal mucin recognition by galectin‐3 and C‐type lectins Open
Intestinal mucins trigger immune responses upon recognition by dendritic cells via protein–carbohydrate interactions. We used a combination of structural, biochemical, biophysical, and cell‐based approaches to decipher the specificity of t…
View article: Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors
Lactobacillus reuteri Surface Mucus Adhesins Upregulate Inflammatory Responses Through Interactions With Innate C-Type Lectin Receptors Open
The vertebrate gut symbiont Lactobacillus reuteri exhibits strain-specific adhesion and health-promoting properties. Here, we investigated the role of the mucus adhesins, CmbA and MUB, upon interaction of L. reuteri ATCC PTA …
View article: The StcE metalloprotease of enterohaemorrhagic<i>Escherichia coli</i>reduces the inner mucus layer and promotes adherence to human colonic epithelium<i>ex vivo</i>
The StcE metalloprotease of enterohaemorrhagic<i>Escherichia coli</i>reduces the inner mucus layer and promotes adherence to human colonic epithelium<i>ex vivo</i> Open
Enterohaemorrhagic Escherichia coli (EHEC) is a major foodborne pathogen and tightly adheres to human colonic epithelium by forming attaching/effacing lesions. To reach the epithelial surface, EHEC must penetrate the thick mucus layer prot…
View article: Use of Atomic Force Microscopy to Study the Multi-Modular Interaction of Bacterial Adhesins to Mucins
Use of Atomic Force Microscopy to Study the Multi-Modular Interaction of Bacterial Adhesins to Mucins Open
The mucus layer covering the gastrointestinal (GI) epithelium is critical in selecting and maintaining homeostatic interactions with our gut bacteria. However, the molecular details of these interactions are not well understood. Here, we p…
View article: The intestinal glycome and its modulation by diet and nutrition
The intestinal glycome and its modulation by diet and nutrition Open
The human gastrointestinal epithelium is responsible for adequate digestion and absorption of nutrients. It is an immunological interface and highly selective environment that facilitates colonization by commensal bacteria and prohibits ad…
View article: Mucin glycan foraging in the human gut microbiome
Mucin glycan foraging in the human gut microbiome Open
The availability of host and dietary carbohydrates in the gastrointestinal (GI) tract plays a key role in shaping the structure-function of the microbiota. In particular, some gut bacteria have the ability to forage on glycans provided by …