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View article: Holobiont Urbanism: sampling urban beehives reveals cities’ metagenomes
Holobiont Urbanism: sampling urban beehives reveals cities’ metagenomes Open
Background Over half of the world’s population lives in urban areas with, according to the United Nations, nearly 70% expected to live in cities by 2050. Our cities are built by and for humans, but are also complex, adaptive biological sys…
View article: Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results
Laboratory-Generated DNA Can Cause Anomalous Pathogen Diagnostic Test Results Open
To meet the challenges imposed by the COVID-19 pandemic, research laboratories shifted their focus and clinical diagnostic laboratories developed and utilized new assays. Nucleic acid-based testing became widespread and, for the first time…
View article: Lab-on-a-chip multiplexed electrochemical sensor enables simultaneous detection of SARS-CoV-2 RNA and host antibodies
Lab-on-a-chip multiplexed electrochemical sensor enables simultaneous detection of SARS-CoV-2 RNA and host antibodies Open
The current COVID-19 pandemic highlights the continued need for rapid, accurate, and cost-effective point-of-care (POC) diagnostics that can accurately assess an individual’s infection and immunity status for SARS-CoV-2. As the virus conti…
View article: Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants
Minimally instrumented SHERLOCK (miSHERLOCK) for CRISPR-based point-of-care diagnosis of SARS-CoV-2 and emerging variants Open
An integrated, low-cost, sample-to-answer, CRISPR-based diagnostic detects SARS-CoV-2 and variants from unprocessed saliva.
View article: Therapeutic gene editing is here, can regulations keep up?
Therapeutic gene editing is here, can regulations keep up? Open
Genome editing and the technologies that enable it have sparked public discussions as investments in research and development continue to soar. Available gene editing modalities are enabling far-reaching applications beyond heritable genom…
View article: Holobiont Urbanism: sampling urban beehives reveals cities’ metagenomes
Holobiont Urbanism: sampling urban beehives reveals cities’ metagenomes Open
Over half of the world’s population lives in urban areas with, according to the United Nations (UN), nearly 70% expected to live in cities by 2050 (United Nations, 2019). Our cities are built by and for humans, but are also complex, adapti…
View article: Harnessing gene drive
Harnessing gene drive Open
When scientists alter the genome of an organism, we typically reduce its ability to reproduce in the wild. This limitation has prevented researchers from rendering wild insects unable to spread disease, programing pests to ignore our crops…
View article: Driving towards ecotechnologies
Driving towards ecotechnologies Open
The prospect of using genetic methods to target vector, parasite, and reservoir species offers tremendous potential benefits to public health, but the use of genome editing to alter the shared environment will require special attention to …
View article: Daisy quorum drives for the genetic restoration of wild populations
Daisy quorum drives for the genetic restoration of wild populations Open
An ideal gene drive system to alter wild populations would 1) exclusively affect organisms within the political boundaries of consenting communities, and 2) be capable of restoring any engineered population to its original genetic state. H…
View article: Daisyfield gene drive systems harness repeated genomic elements as a generational clock to limit spread
Daisyfield gene drive systems harness repeated genomic elements as a generational clock to limit spread Open
Methods of altering wild populations are most useful when inherently limited to local geographic areas. Here we describe a novel form of gene drive based on the introduction of multiple copies of an engineered ‘daisy’ sequence into repeate…