De‐Wei Gao
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View article: Catalytic Asymmetric Construction of Nonadjacent Stereoelements
Catalytic Asymmetric Construction of Nonadjacent Stereoelements Open
Nonadjacent chiral scaffolds are privileged motifs in bioactive molecules and medicines, which have stimulated chemists’ ingenuity in achieving the asymmetric construction of non‐contiguous chiral elements directly. Current strategies incl…
View article: Catalytic Asymmetric Construction of Nonadjacent Stereoelements
Catalytic Asymmetric Construction of Nonadjacent Stereoelements Open
Nonadjacent chiral scaffolds are privileged motifs in bioactive molecules and medicines, which have stimulated chemists’ ingenuity in achieving the asymmetric construction of non‐contiguous chiral elements directly. Current strategies incl…
View article: Recent Advances in Catalytic Asymmetric Synthesis of Chiral 1,2-Bis(boronic) Esters
Recent Advances in Catalytic Asymmetric Synthesis of Chiral 1,2-Bis(boronic) Esters Open
Chiral 1,2-bis(boronic) esters are essential building blocks in the field of synthetic chemistry, and their catalytic asymmetric synthesis has attracted significant interest of chemists.Recently, asymmetric diboration of olefins, using tra…
View article: β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis
β-Terrecyclene synthase constructs the quadrane backbone in terrecyclic acid biosynthesis Open
The construction of a quadrane scaffold by β-terrecyclene synthase via Coates' route is demonstrated through mutagenesis and isotopically sensitive branching studies. Subsequent enzymatic modifications convert β-terrecyclene into terrecycl…
View article: Controllable Regiodivergent Alkynylation of 1,3‐Bis(Boronic) Esters Activated by Distinct Organometallic Reagents
Controllable Regiodivergent Alkynylation of 1,3‐Bis(Boronic) Esters Activated by Distinct Organometallic Reagents Open
1,3‐Bis(boronic) esters can be readily synthesized from alkylBpin precursors. Selective transformations of these compounds hold the potential for late‐stage functionalization of the remaining C−B bond, leading to a diverse array of molecul…
View article: Clinical characteristics and outcomes in patients with Takayasu arteritis coexisting with myocardial ischemia and neurological symptoms: A multicenter, long-term, follow-up study
Clinical characteristics and outcomes in patients with Takayasu arteritis coexisting with myocardial ischemia and neurological symptoms: A multicenter, long-term, follow-up study Open
Background The incidence of coexisting myocardial ischemia and neurological symptoms in Takayasu arteritis (TA) is currently unknown. There is no standardized treatment algorithm in complex cases involving the coronary and intracranial art…
View article: A Polyketide Cyclase That Forms Medium-Ring Lactones
A Polyketide Cyclase That Forms Medium-Ring Lactones Open
Medium-ring lactones are synthetically challenging due to unfavorable energetics involved in cyclization. We have discovered a thioesterase enzyme DcsB, from the decarestrictine C1 (1) biosynthetic pathway, that efficiently performs medium…
View article: Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products
Cascade CuH-Catalyzed Conversion of Alkynes to Enantioenriched 1,1-Disubstituted Products Open
Enantioenriched α -aminoboronic acids play a unique role in medicinal chemistry and have emerged as privileged pharmacophores in proteasome inhibitors. Additionally, they represent synthetically useful chiral building blocks in organic syn…
View article: Catalytic, Enantioselective Synthesis of Allenyl Boronates
Catalytic, Enantioselective Synthesis of Allenyl Boronates Open
A method to achieve enantioselective 1,4-hydroboration of terminal enynes to access allenyl boronates under CuH catalysis is described. The reaction typically proceeds in a highly stereoselective manner and tolerates an array of synthetica…
View article: Catalytic, Enantioselective Synthesis of Allenyl Boronates
Catalytic, Enantioselective Synthesis of Allenyl Boronates Open
A method to achieve enantioselective 1,4-hydroboration of terminal enynes to access allenyl boronates under CuH catalysis is described. The reaction typically proceeds in a highly stereoselective manner and tolerates an array of synthetica…
View article: Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization
Tridentate Directing Groups Stabilize 6-Membered Palladacycles in Catalytic Alkene Hydrofunctionalization Open
Removable tridentate directing groups inspired by pincer ligands have been designed to stabilize otherwise kinetically and thermodynamically disfavored 6-membered alkyl palladacycle intermediates. This family of directing groups enables re…
View article: Organocatalytic asymmetric chlorinative dearomatization of naphthols
Organocatalytic asymmetric chlorinative dearomatization of naphthols Open
A highly enantioselective chlorinative dearomatization of 1-naphthol and 2-naphthols was realized for the first time, providing chiral naphthalenones with a Cl-containing all-substituted stereocenter in excellent yields and enantioselectiv…