Dewi Clark
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View article: Best Practices for Non‐Pharmacological Treatments for Older Adults in the Geriatric Mental Health Outpatient Services (GMHOS) at the Centre for Addiction and Mental Health (CAMH)
Best Practices for Non‐Pharmacological Treatments for Older Adults in the Geriatric Mental Health Outpatient Services (GMHOS) at the Centre for Addiction and Mental Health (CAMH) Open
Background The Geriatric Mental Health Outpatient Services (GMHOS) at the Centre for Addiction and Mental Health (CAMH) in Toronto, Ontario, deliver evidence‐based care to older adults with complex mental health conditions. GMHOS currently…
View article: Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians
Asian Cohort for Alzheimer's Disease (ACAD) pilot study on genetic and non‐genetic risk factors for Alzheimer's disease among Asian Americans and Canadians Open
INTRODUCTION Clinical research in Alzheimer's disease (AD) lacks cohort diversity despite being a global health crisis. The Asian Cohort for Alzheimer's Disease (ACAD) was formed to address underrepresentation of Asians in research, and li…
View article: Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size
Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size Open
"Neurovascular Complications and Pulmonary Arteriovenous Malformation Feeding Artery Size." Annals of the American Thoracic Society, 19(8), pp. 1432–1435
View article: Quantification metrics for telangiectasia using optical coherence tomography
Quantification metrics for telangiectasia using optical coherence tomography Open
Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder that causes vascular malformations throughout the body. The most prevalent and accessible of these lesions are found throughout the skin and mucosa, and often ru…
View article: Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations
Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations Open
Background Vascular malformations in the central nervous system are difficult to monitor and treat due to their inaccessible location. Angiogenic and inflammatory proteins are secreted into the bloodstream and may serve as useful biomarker…
View article: Additional file 1 of Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations
Additional file 1 of Pilot investigation of circulating angiogenic and inflammatory biomarkers associated with vascular malformations Open
Additional file 1: Table S1. Linear regression of biomarker levels between vascular malformation diseases. CI = confidence interval; PI = proportional increase; Bold values indicate markers with a q-value less than 0.05. Sample sizes vary …
View article: Genotype–Phenotype Correlations in Children with HHT
Genotype–Phenotype Correlations in Children with HHT Open
Hereditary hemorrhagic telangiectasia (HHT), a rare autosomal dominant disease mostly caused by mutations in three known genes (ENG, ACVRL1, and SMAD4), is characterized by the development of vascular malformations (VMs). Patients with HHT…
View article: Reduction of endoglin receptor impairs mononuclear cell-migration
Reduction of endoglin receptor impairs mononuclear cell-migration Open
Aim: To test if the impairment of mononuclear cell (MNC) migration in patients with hereditary hemorrhagic telangiectasia (HHT) is due to the reduction of the endoglin (ENG) receptor on the cell surface and oxidative stress. Method: MNCs o…
View article: Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i>
Somatic Mutations in Vascular Malformations of Hereditary Hemorrhagic Telangiectasia Result in Biallelic Loss of <i>ENG</i> or <i>ACVRL1</i> Open
Hereditary Hemorrhagic Telangiectasia (HHT) is a Mendelian disease characterized by vascular malformations including visceral arteriovenous malformations and mucosal telangiectasia. HHT is caused by loss-of-function mutations in one of 3 g…