Deyan Liu
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View article: Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes
Multi-hit TP53 mutation is an independent adverse prognostic factor in allogeneic hematopoietic stem cell transplantation for acute leukemia and myelodysplastic syndromes Open
Introduction TP53-mutated hematologic malignancies carry a notoriously poor prognosis, particularly in cases with multi-hit TP53 alterations. Recent WHO (2022) and ICC classifications define TP53-mutated myeloid neoplasms as a distinct ent…
View article: Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia
Clinical efficacy of allogeneic hematopoietic stem cell transplantation in infant acute leukemia Open
Introduction Infant leukemia, including AML and ALL occurring within the first year of life, is a rare and aggressive disease with poor prognosis. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a crucial treatment option…
View article: Optimizing letermovir timing: Day +5 to +8 post haplo-HSCT minimizes EBV dnaemia without compromising CMV prophylaxis
Optimizing letermovir timing: Day +5 to +8 post haplo-HSCT minimizes EBV dnaemia without compromising CMV prophylaxis Open
Background The era of Letermovir (LTV) has reshaped CMV prophylaxis and treatment following allogeneic HSCT, with its efficacy in reducing CMV infection well established. However, emerging evidence suggests an association between LTV expos…
View article: No reduction in gvhd risk for aplastic anemia patients to combined third-party unrelated cord blood in haploidentical hematopoietic stem cells transplantation
No reduction in gvhd risk for aplastic anemia patients to combined third-party unrelated cord blood in haploidentical hematopoietic stem cells transplantation Open
Background Aplastic anemia (AA) is a disease characterized by bone marrow failure. Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is an effective treatment for AA. However, some patients experience transplantation failure o…
View article: Allogeneic hematopoietic stem cell transplantation in sil::TAL1-positive T-ALL: Prognostic impact of pre-transplant remission and molecular status
Allogeneic hematopoietic stem cell transplantation in sil::TAL1-positive T-ALL: Prognostic impact of pre-transplant remission and molecular status Open
Introduction The SIL::TAL1 fusion gene, caused by a 1p32 deletion, is a common molecular alteration in T-cell acute lymphoblastic leukemia (T-ALL), with an incidence of 16–29%. It promotes leukemogenesis via aberrant activation of the TAL1…
View article: The impact of HLA loss of heterozygosity on outcome after haploidentical hematopoietic stem cell transplantation in hematological malignancies
The impact of HLA loss of heterozygosity on outcome after haploidentical hematopoietic stem cell transplantation in hematological malignancies Open
Background: Genomic loss of the mismatched HLA haplotype (HLA-Loss) is a frequent mechanism of immune evasion and relapse following haploidentical hematopoietic stem cell transplantation (haplo-HSCT). Prognostic data in the era of novel im…
View article: Clinical features and fusion gene analysis of two Torque Teno Mini virus associated acute promyelocytic leukemia cases
Clinical features and fusion gene analysis of two Torque Teno Mini virus associated acute promyelocytic leukemia cases Open
Torque Teno Mini Virus (TTMV), a member of the Anelloviridae family, is a commensal component of the human virome. Since the initial identification of the TTMV::RARA fusion gene as a novel driver of acute promyelocytic leukemia (APL), 15 c…
View article: Wetland restoration suppresses microbial carbon metabolism by altering keystone species interactions
Wetland restoration suppresses microbial carbon metabolism by altering keystone species interactions Open
Soil bacteria play a pivotal role in regulating multifaceted functions of terrestrial ecosystems. Unraveling the succession of bacterial communities and the feedback mechanism on soil organic carbon (SOC) dynamics help embed the ecology of…
View article: Dairy effluent mitigates N2O missions while extreme precipitation stimulates N2O losses in a sandy soil
Dairy effluent mitigates N2O missions while extreme precipitation stimulates N2O losses in a sandy soil Open
Dairy effluents instead of mineral fertilizer can realize nutrients recycling while urease inhibitors have been proposed as fertilizer amendments to maximize nutrients utilization and reduce negative environmental effects. However, studies…
View article: Nitrification inhibitors reduce N2O emissions from Mollisols by potentially targeting Nitrosospira cluster 3a and denitrifiers
Nitrification inhibitors reduce N2O emissions from Mollisols by potentially targeting Nitrosospira cluster 3a and denitrifiers Open
Nitrification inhibitors (NIs) are widely used to mitigate nitrous oxide (N2O) emissions from agricultural soils. However, its efficiency is highly uncertain owing to varying environmental conditions and still-debated inhibition mechanisms…
View article: Analysis of the Spatio-Temporal Coupling and Coordination Relationship Between Agricultural Eco-Efficiency and Economic Development Level: A Case Study of 75 Cities in East China
Analysis of the Spatio-Temporal Coupling and Coordination Relationship Between Agricultural Eco-Efficiency and Economic Development Level: A Case Study of 75 Cities in East China Open
Agricultural eco-efficiency is a crucial indicator for assessing the coordinated development of agriculture and the environment. Studying its interaction with economic development levels is beneficial for promoting high-quality agricultura…
View article: Comparable OS and Gffs of ATLG Vs. Ratg for Gvhd Prophylaxis in Pediatric AA Patients Undergoing Transplantation
Comparable OS and Gffs of ATLG Vs. Ratg for Gvhd Prophylaxis in Pediatric AA Patients Undergoing Transplantation Open
Objective: The pathogenesis of AA (aplastic anemia) involves multiple factors, including hematopoietic stem cell dysfunction, immune dysfunction and hematopoietic microenvironment abnormalities. Notably, the abnormal activation and hyperfu…
View article: Long‐term application of mineral fertilizer weakens the stability of microbial N‐transforming functions via the decrease of soil microbial diversity
Long‐term application of mineral fertilizer weakens the stability of microbial N‐transforming functions via the decrease of soil microbial diversity Open
Introduction Ensuring functional stability is crucial for the sustainable development and soil health of agroecosystems amidst escalating climate changes. Although mineral fertilization is known to enhance the strength of soil N‐transformi…
View article: Inter- and intra-annual variability and climatic responses of ecosystem water use efficiency in a cool-temperate freshwater wetland
Inter- and intra-annual variability and climatic responses of ecosystem water use efficiency in a cool-temperate freshwater wetland Open
Wetland ecosystems play a pivotal role in terrestrial carbon and water cycles, thereby possessing great potential to regulate terrestrial water use efficiency (WUE), which is calculated as the ratio of gross primary productivity (GPP) to e…
View article: A safety and efficacy study of allogeneic haematopoietic stem cell transplantation for refractory and relapsed T‐cell acute lymphoblastic leukaemia/lymphoblastic lymphoma patients who achieved complete remission after autologous <scp>CD7</scp> chimeric antigen receptor T‐cell therapy
A safety and efficacy study of allogeneic haematopoietic stem cell transplantation for refractory and relapsed T‐cell acute lymphoblastic leukaemia/lymphoblastic lymphoma patients who achieved complete remission after autologous <span>CD7</span> chimeric antigen receptor T‐cell therapy Open
Summary CD7‐targeted chimeric antigen receptor T‐cell (CAR‐T) therapy has shown promising initial complete remission (CR) rates in patients with refractory or relapsed (r/r) T‐cell acute lymphoblastic leukaemia and lymphoblastic lymphoma (…
View article: Foregone carbon sequestration loss dominates greenhouse gas budget in mariculture associated with coastal wetland conversion
Foregone carbon sequestration loss dominates greenhouse gas budget in mariculture associated with coastal wetland conversion Open
Coastal wetlands represent a disproportionately large global carbon (C) sink. However, they are threatened by the ever-expanding aquaculture and being lost at critical rates. Conversion of coastal wetlands to aquaculture systems has been p…
View article: Efficacy and Safety Analysis of Prophylactic Brentuximab Vedotin Administration after Pediatric Acute Leukemia Haploidentical Hematopoietic Stem Cell Transplantation
Efficacy and Safety Analysis of Prophylactic Brentuximab Vedotin Administration after Pediatric Acute Leukemia Haploidentical Hematopoietic Stem Cell Transplantation Open
Objective: Acute graft-versus-host disease (aGVHD) is a common complication following allogeneic hematopoietic stem cell transplantation. Currently, the reported incidence of moderate to severe aGVHD in domestic cases is 13%-47%, while the…
View article: P1515: METAGENOMIC NEXT-GENERATION SEQUENCING BASED DIAGNOSIS OF NON-ASPERGILLUS MOLD INFECTIONS IN PATIENTS WHO RECEIVED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER STUDY
P1515: METAGENOMIC NEXT-GENERATION SEQUENCING BASED DIAGNOSIS OF NON-ASPERGILLUS MOLD INFECTIONS IN PATIENTS WHO RECEIVED ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION: A SINGLE-CENTER STUDY Open
Topic: 22. Stem cell transplantation - Clinical Background: Non-Aspergillus mold infection (NAMI) is a rare invasive fungal infection in patients who received allogeneic hematopoietic stem cell transplantation (allo-HSCT) and noninvasive d…
View article: Analysis benefits of a second Allo-HSCT after CAR-T cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia who relapsed after transplant
Analysis benefits of a second Allo-HSCT after CAR-T cell therapy in patients with relapsed/refractory B-cell acute lymphoblastic leukemia who relapsed after transplant Open
Background Chimeric antigen receptor (CAR) T-cell therapy has demonstrated high initial complete remission (CR) rates in B-cell acute lymphoblastic leukemia (B-ALL) patients, including those who relapsed after transplant. However, the dura…
View article: Approximate Gaussian kernel mapping incremental LSSVR based on knowledge transfer and its industrial application
Approximate Gaussian kernel mapping incremental LSSVR based on knowledge transfer and its industrial application Open
Aiming at the problem of diversified and time-varying data in industrial energy forecast, an incremental least squares support vector regression model based on approximate Gaussian kernel mapping and knowledge transfer is proposed. Firstly…
View article: Non-native Brachiaria humidicola with biological nitrification inhibition capacity stimulates in situ grassland N2O emissions
Non-native Brachiaria humidicola with biological nitrification inhibition capacity stimulates in situ grassland N2O emissions Open
Introduction Brachiaria humidicola , a tropical grass, could release root exudates with biological nitrification inhibition (BNI) capacity and reduce soil nitrous oxide (N 2 O) emissions from grasslands. However, evidence of the reduction …
View article: Prognostic factors of second hematopoietic allogeneic stem cell transplantation among hematological malignancy patients relapsed after first hematopoietic stem cell transplantation: A single center study
Prognostic factors of second hematopoietic allogeneic stem cell transplantation among hematological malignancy patients relapsed after first hematopoietic stem cell transplantation: A single center study Open
Introduction We aimed to evaluate prognostic factors of a second allogeneic stem cell transplantation (allo-HSCT2) among hematological malignancy patients who have relapsed after the first allo-HSCT(allo-HSCT1). Methods We retrospectively …
View article: Brachiaria humidicola Cultivation Enhances Soil Nitrous Oxide Emissions from Tropical Grassland by Promoting the Denitrification Potential: A 15N Tracing Study
Brachiaria humidicola Cultivation Enhances Soil Nitrous Oxide Emissions from Tropical Grassland by Promoting the Denitrification Potential: A 15N Tracing Study Open
Biological nitrification inhibition (BNI) in the tropical grass Brachiaria humidicola could reduce net nitrification rates and nitrous oxide (N2O) emissions in soil. To determine the effect on gross nitrogen (N) transformation processes an…
View article: Gynecological complications in long-term survivors after allogeneic hematopoietic cell transplantation—a single-center real-life cross-sectional study
Gynecological complications in long-term survivors after allogeneic hematopoietic cell transplantation—a single-center real-life cross-sectional study Open
Background and objectives Hematopoietic stem cell transplantation (HCT) is a treatment for hematopoietic diseases. However, most cured female patients may suffer from premature ovarian insufficiency (POI) after HCT, which is mainly caused …