Deyu Chen
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View article: Adapt in the Wild: Test-Time Entropy Minimization with Sharpness and Feature Regularization
Adapt in the Wild: Test-Time Entropy Minimization with Sharpness and Feature Regularization Open
Test-time adaptation (TTA) may fail to improve or even harm the model performance when test data have: 1) mixed distribution shifts, 2) small batch sizes, 3) online imbalanced label distribution shifts. This is often a key obstacle prevent…
View article: Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance
Short peptide perturbs spermatogenesis via immune microenvironment dysregulation and mitochondrial imbalance Open
A short peptide derived from the occludin protein regulates tight junctions (TJ) of the blood–testis barrier and impairs germ cell development. However, the mechanism behind how this peptide regulates TJ and induces cell apoptosis remains …
View article: Numerical simulation of hot soak in cabin based on ventilation strategy
Numerical simulation of hot soak in cabin based on ventilation strategy Open
To address the issue of excessive heat within the vehicle’s cabin, this study employs transient simulation methods to explore and analyze how various ventilation tactics and parameters influence the cabin’s temperature distribution and air…
View article: Lower early-stage rectal cancer surgical approaches: Therapeutic options and cancer biomarker alterations
Lower early-stage rectal cancer surgical approaches: Therapeutic options and cancer biomarker alterations Open
Background Early-stage rectal cancer is used in cases of histological findings including pTis and pT1 tumors, which are no metastases, no lymphovascular or perineural invasion, and located at the mucosa level of the intestinal wall. Low ea…
View article: Mitochondrial supercomplex assembly regulates metabolic features and glutamine dependency in mammalian cells
Mitochondrial supercomplex assembly regulates metabolic features and glutamine dependency in mammalian cells Open
Rationale: Mitochondria generate ATP via the oxidative phosphorylation system, which mainly comprises five respiratory complexes found in the inner mitochondrial membrane. A high-order assembly of respiratory complexes is called a supercom…
View article: A retrospective analysis of transanal surgical management of 291 cases with rectal foreign bodies
A retrospective analysis of transanal surgical management of 291 cases with rectal foreign bodies Open
Background: Rectal foreign bodies (RFB) are quite uncommon except in very busy hospitals. Because of their rarity, it is seldom that the treating physicians have a standard approach to the diagnosis, technique of extraction, and post-extra…
View article: Identification of ferroptosis-related subtypes, characteristics of TME infiltration and development of prognostic models in gastric cancer
Identification of ferroptosis-related subtypes, characteristics of TME infiltration and development of prognostic models in gastric cancer Open
Purpose: Ferroptosis is a new type of cell death in morphology, biochemistry and genetics, and is closely related to the occurrence, development, prognosis and treatment of tumors. However, the potential role of ferroptosis-related genes (…
View article: Knowledge and willingness to receive a COVID-19 vaccine: a survey from Anhui Province, China
Knowledge and willingness to receive a COVID-19 vaccine: a survey from Anhui Province, China Open
In general, the participants, the staff of geriatric care facilities in Anhui Province, had good mastery of the COVID-19 vaccine, and they were willing to get vaccinated. However, there still existed a few participants with poor knowledge,…
View article: Research on the Impact of Economic Policy Uncertainty on Corporate R&D Innovation: Evidence of China’s Strategic Emerging Industries
Research on the Impact of Economic Policy Uncertainty on Corporate R&D Innovation: Evidence of China’s Strategic Emerging Industries Open
Based on the data of China’s A-share listed strategic emerging industry companies from 2011 to 2019, this paper discusses the impact of economic policy uncertainty on R&D innovation. The research shows that the uncertainty of economic poli…
View article: Therapeutic effects of the TST36 stapler on rectocele combined with internal rectal prolapse
Therapeutic effects of the TST36 stapler on rectocele combined with internal rectal prolapse Open
The TST36 stapler is safe and effective in treating rectocele combined with internal rectal prolapse and is worth promoting in clinical work.
View article: A Brief Talk on the Construction of New Countryside in Pearl River Delta
A Brief Talk on the Construction of New Countryside in Pearl River Delta Open
The issue of agriculture, rural areas and farmers has always been a key issue in our country's modernization drive.Since the reform and opening up, China's rural construction has made great achievements, especially in the Pearl River Delta…
View article: On the Construction of New Countryside in the Pearl River Delta
On the Construction of New Countryside in the Pearl River Delta Open
Agriculture, rural areas and farmers have traditionally been the key issues in our country's modernization.Since the reform and opening up, especially the rural areas in the Pearl River Delta region, rely on the superior geographical locat…
View article: Discussion on the Mechanism of Internet Finance Promoting the Development of Technology Finance
Discussion on the Mechanism of Internet Finance Promoting the Development of Technology Finance Open
Internet finance can effectively solve the problem of scientific and technological financial information asymmetry, identify financial risks, and provide new ideas for the innovation and development of financial technology mechanisms. Base…
View article: Peer Review #1 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.2)"
Peer Review #1 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.2)" Open
Occludin is a structural protein of tight junctions (TJ) in the blood-testis barrier (BTB).A 22amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown.In this study, a …
View article: A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis
A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis Open
Occludin is a structural protein of tight junctions (TJ) in the blood–testis barrier (BTB). A 22-amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown. In this study,…
View article: Peer Review #3 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.1)"
Peer Review #3 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.1)" Open
Occludin is a structural protein of tight junctions (TJ) in the blood-testis barrier (BTB).A 22amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown.In this study, a …
View article: Peer Review #1 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.1)"
Peer Review #1 of "A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis (v0.1)" Open
Occludin is a structural protein of tight junctions (TJ) in the blood-testis barrier (BTB).A 22amino-acid peptide (22AA) in the second extracellular loop can reversibly regulate TJ, but its regulatory mechanism is unknown.In this study, a …
View article: Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020
Consensus statement on diagnosis and treatment of cervical ossification of posterior longitudinal ligament from Asia Pacific Spine Society (APSS) 2020 Open
Purpose: The study aimed to develop an evidence-based expert consensus statement on diagnosis and treatment of cervical ossification posterior longitudinal ligament (OPLL). Method: Delphi method was used to perform such survey, and the pan…
View article: SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway
SREBP1 silencing inhibits the proliferation and motility of human esophageal squamous carcinoma cells via the Wnt/β‑catenin signaling pathway Open
Sterol regulatory element-binding protein 1 (SREBP1) is dysregulated in a variety of types of human cancer. However, the functional roles of SREBP1 in esophageal squamous cell carcinoma (ESCC) remain poorly understood. The present study in…
View article: Effects of Length and Loop Composition on Structural Diversity and Similarity of (G3TG3NmG3TG3) G-Quadruplexes
Effects of Length and Loop Composition on Structural Diversity and Similarity of (G3TG3NmG3TG3) G-Quadruplexes Open
A G-rich sequence containing three loops to connect four G-tracts with each ≥2 guanines can possibly form G-quadruplex structures. Given that all G-quadruplex structures comprise the stacking of G-quartets, the loop sequence plays a major …
View article: Systematic analysis of a mitochondrial disease‐causing <i>ND6</i> mutation in mitochondrial deficiency
Systematic analysis of a mitochondrial disease‐causing <i>ND6</i> mutation in mitochondrial deficiency Open
Background The m.14487T>C mutation is recognized as a diagnostic mutation of mitochondrial disease during the past 16 years, emerging evidence suggests that mutant loads of m.14487T>C and disease phenotype are not closely correlated. Metho…
View article: Discussion on Corporate Solvency Taking Gree Electric Appliance as an Example
Discussion on Corporate Solvency Taking Gree Electric Appliance as an Example Open
The analysis of solvency is an important part of corporate financial analysis. It is of great significance for improving the solvency of enterprises and promoting the healthy development of enterprises. This article takes Gree Electric App…
View article: The endoplasmic reticulum stress response participates in connexin 43-mediated ossification of the posterior longitudinal ligament.
The endoplasmic reticulum stress response participates in connexin 43-mediated ossification of the posterior longitudinal ligament. Open
Ossification of the posterior longitudinal ligament (OPLL) manifests as ectopic bone formation in spinal ligament tissue. As revealed by in vitro studies, fibroblasts from patients with OPLL or healthy ligament fibroblasts undergo mechanic…
View article: Cultivation of Practical Competence of Students in Dispute Advertising Design
Cultivation of Practical Competence of Students in Dispute Advertising Design Open
The practical teaching of advertisement major provides a good platform.Higher vocational graduates 'knowledge level ability is not high, comprehensive ability and competition consciousness are weak, there is no reasonable business consciou…