De Yun Wang
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View article: Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review
Traditional uses, nutritional properties, phytochemical metabolites, pharmacological properties, and potential applications of Lilium spp.: a systematic review Open
Introduction Lilium spp., perennial bulbous plants native to the Northern Hemisphere, have long been valued in traditional medicine, particularly across Asia. The bulbs of Lilium brownii (“Bai He” in traditional Chinese medicine) have been…
Colonization by Porphyromonas gingivalis in cervical squamous cell carcinomas promotes metastasis through FimA/CD151/ITGB1 signaling Open
This study identifies P. gingivalis as a tumor-associated bacterium that promotes CSCC metastasis through direct interaction between its fimbrial adhesin FimA and the host CD151/ITGB1 complex. This interaction activates JNK/paxillin signal…
Club Cells in Nasal Epithelial Repair: Insights From an IL‐13‐Induced Inflammatory Model Open
Background Club cells, originating from basal cells, can differentiate into ciliated or goblet cells in the lower respiratory tract, but their role in nasal epithelium during chronic rhinosinusitis with nasal polyps (CRSwNP) is not well un…
View article: SFT Doesn't Always Hurt General Capabilities: Revisiting Domain-Specific Fine-Tuning in LLMs
SFT Doesn't Always Hurt General Capabilities: Revisiting Domain-Specific Fine-Tuning in LLMs Open
Supervised Fine-Tuning (SFT) on domain-specific datasets is a common approach to adapt Large Language Models (LLMs) to specialized tasks but is often believed to degrade their general capabilities. In this work, we revisit this trade-off a…
View article: International Evidence‐Based Guidelines for Traditional Chinese Medicine Management of Allergic Rhinitis
International Evidence‐Based Guidelines for Traditional Chinese Medicine Management of Allergic Rhinitis Open
Allergic rhinitis (AR) is a prevalent chronic condition that significantly impacts patients' quality of life and poses challenges to effective management. Traditional Chinese medicine (TCM) offers a holistic approach, emphasizing syndrome …
View article: Professor Du’s Experience in Treating Chronic Atrophic Gastritis from the Perspective of the Shaoyang Pivot Using Xiaochaihu Decoction
Professor Du’s Experience in Treating Chronic Atrophic Gastritis from the Perspective of the Shaoyang Pivot Using Xiaochaihu Decoction Open
This article systematically summarizes Professor Du’s clinical experience in treating chronic atrophic gastritis (CAG) with modified Xiaochaihu Decoction. Based on the theory of Six-Meridian transmission from the Shanghan Lun, Professor Du…
SurgWound-Bench: A Benchmark for Surgical Wound Diagnosis Open
Surgical site infection (SSI) is one of the most common and costly healthcare-associated infections and and surgical wound care remains a significant clinical challenge in preventing SSIs and improving patient outcomes. While recent studie…
Advancements in understanding tumor-resident bacteria and their application in cancer therapy Open
Recent advances in next-generation sequencing and bioinformatics have driven growing interest in the distinct roles of intratumoral microbiota, particularly intracellular bacteria, during tumor evolution. These bacteria increase the likeli…
Shop-R1: Rewarding LLMs to Simulate Human Behavior in Online Shopping via Reinforcement Learning Open
Large Language Models (LLMs) have recently demonstrated strong potential in generating 'believable human-like' behavior in web environments. Prior work has explored augmenting training data with LLM-synthesized rationales and applying supe…
Long‐Term Outcomes of Optimized Surgery and Medication in Chronic Rhinosinusitis With Nasal Polyps Open
Objective Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) is predominantly associated with type 2 inflammation (85.4%) and significant disease severity. This study aims to investigate the overall control status of CRSwNP patients one to …
[Effects of acellular allogeneic dermis combined with autologous split-thickness skin grafts in repairing deep burn wounds in head, face, neck, and torso in children]. Open
Objective: To analyze the effects of acellular allogeneic dermis combined with autologous split-thickness skin grafts in repairing deep burn wounds in head, face, neck, and torso in children. Methods: This study was a historical control st…
View article: OPeRA: A Dataset of Observation, Persona, Rationale, and Action for Evaluating LLMs on Human Online Shopping Behavior Simulation
OPeRA: A Dataset of Observation, Persona, Rationale, and Action for Evaluating LLMs on Human Online Shopping Behavior Simulation Open
Can large language models (LLMs) accurately simulate the next web action of a specific user? While LLMs have shown promising capabilities in generating ``believable'' human behaviors, evaluating their ability to mimic real user behaviors r…
Chronic rhinosinusitis in nasopharyngeal carcinoma patients post- IMRT: a meta-analysis Open
Background: Intensity-modulated radiotherapy (IMRT) for nasopharyngeal carcinoma (NPC) can cause chronic rhinosinusitis (CRS), an underexplored side effect. This review aimed to determine the incidence and severity of CRS in NPC patients p…
View article: Crucial role for iron metabolism in mediating influenza A virus infection and associated disease
Crucial role for iron metabolism in mediating influenza A virus infection and associated disease Open
Rationale and Objectives Iron availability and metabolism are important in the pathogenesis of bacterial infections. More recently, links have been reported between iron and the severity of viral infections. In this study, we characterize …
Inhibitory Activity of Hydroxypropyl Methylcellulose on Rhinovirus and Influenza A Virus Infection of Human Nasal Epithelial Cells Open
The nasal epithelium is the primary site for entry of respiratory viruses. In comparison to oral administration, nasal drug applications directed locally to the site of infection can serve as early interventional barriers against respirato…
Towards a Design Guideline for RPA Evaluation: A Survey of Large Language Model-Based Role-Playing Agents Open
Role-Playing Agent (RPA) is an increasingly popular type of LLM Agent that simulates human-like behaviors in a variety of tasks. However, evaluating RPAs is challenging due to diverse task requirements and agent designs. This paper propose…
Hsa_circRNA_100791 Modulates Trim13 Through Sponging miR-487b-5p to Facilitate Inflammation in Allergic Rhinitis Open
Our study demonstrated that hsa_circRNA_100791 mitigates the inhibitory effect of miR-487b-5p on Trim13 by directly binding to miR-487b-5p. This interaction regulates the expression of inflammatory factors and facilitates AR. Thus, hsa_cir…
View article: The epithelial barrier theory and its associated diseases
The epithelial barrier theory and its associated diseases Open
The prevalence of many chronic noncommunicable diseases has been steadily rising over the past six decades. During this time, over 350,000 new chemical substances have been introduced to the lives of humans. In recent years, the epithelial…
Person‐centred care in allergen immunotherapy in a digital era Open
In this new digital age, the use of mobile health (mHealth) apps to monitor chronic allergic diseases, including allergic rhinitis (AR) and asthma, has been explored and validated by forward-looking clinicians and researchers.1 Over 2000 m…
Updated epithelial barrier dysfunction in chronic rhinosinusitis: Targeting pathophysiology and treatment response of tight junctions Open
Tight junction (TJ) proteins establish a physical barrier between epithelial cells, playing a crucial role in maintaining tissue homeostasis by safeguarding host tissues against pathogens, allergens, antigens, irritants, etc. Recently, an …