Do‐Gyoon Kim
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View article: Genetic reduction or deletion of osteopontin in osteomalacic <i>Hyp</i> mice fails to ameliorate dentoalveolar defects
Genetic reduction or deletion of osteopontin in osteomalacic <i>Hyp</i> mice fails to ameliorate dentoalveolar defects Open
X-linked hypophosphatemia (XLH) is caused by inactivating mutations in PHEX, leading to disturbed mineral metabolism, rickets, and osteomalacia. Dentoalveolar defects affecting dentin, cementum, and alveolar bone, contribute to dental absc…
View article: Proof-of-principle for enhanced dentoalveolar mineralization using exogenous tissue-nonspecific alkaline phosphatase in the <i>Hyp</i> mouse model of X-linked hypophosphatemia
Proof-of-principle for enhanced dentoalveolar mineralization using exogenous tissue-nonspecific alkaline phosphatase in the <i>Hyp</i> mouse model of X-linked hypophosphatemia Open
X-linked hypophosphatemia (XLH) is caused by mutations in the PHEX gene, which leads to increased levels of fibroblast growth factor 23 and hypophosphatemia, contributing to rickets, osteomalacia, and dentoalveolar defects, including sever…
View article: Performance Comparison of LSTM and ESN Models in Time-Series Prediction of Solar Power Generation
Performance Comparison of LSTM and ESN Models in Time-Series Prediction of Solar Power Generation Open
Improving the prediction accuracy of solar power generation is a critical challenge in promoting sustainable energy solutions. While machine learning models like long short-term memory (LSTM) have gained attention, they face practical limi…
View article: Multiscale Analysis Reveals Altered Characteristics in Femur and Mandible of Mice on a High Phosphate Diet
Multiscale Analysis Reveals Altered Characteristics in Femur and Mandible of Mice on a High Phosphate Diet Open
Excessive phosphate used as flavor enhancers and preservatives in processed foods can exacerbate cardiovascular and kidney diseases. In clinical and pre-clinical studies, chronic (over 52 weeks) high-phosphate diet (HPD) negatively affects…
View article: Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand
Human Bone‐Derived Endothelial Cells Mediate Bone Regeneration via Distinct Expression of KIT Ligand Open
Effective bone regeneration remains a significant challenge in surgical practice, particularly due to the limitations associated with autologous bone grafting, such as donor site morbidity and limited bone availability. This study investig…
View article: Multiscale characterization of jawbone treated with osteoporosis therapeutic agents
Multiscale characterization of jawbone treated with osteoporosis therapeutic agents Open
The objective of the current study was to determine whether treatments of bisphosphonate (alendronate (ALN)), parathyroid hormone (PTH), and their combination have an effect on the jawbone in estrogen deficient rats. Six female rats (4-mon…
View article: Anti-Inflammatory Effects of Honeysuckle Leaf Against Lipopolysaccharide-Induced Neuroinflammation on BV2 Microglia
Anti-Inflammatory Effects of Honeysuckle Leaf Against Lipopolysaccharide-Induced Neuroinflammation on BV2 Microglia Open
Background/Objectives: Neurodegenerative disorders have emerged as a major global public health concern, and the burden is predicted to increase over time. Modulating neuroinflammation and microglial activity is considered a promising targ…
View article: Multi-Scale Characterization of Conventional and Immediate Dental Implant Systems
Multi-Scale Characterization of Conventional and Immediate Dental Implant Systems Open
We hypothesized that the different post-implantation healing stages between the conventional and immediate implantations produce different amounts and tissue composition of the peri-implant bone. Thus, the objective of the current study wa…
View article: Modeling of viscoelastic deformation and rate-dependent fracture damage in rat bone
Modeling of viscoelastic deformation and rate-dependent fracture damage in rat bone Open
Bone is a complex hierarchical structural material whose organ-level response is highly influenced by its constitutive behavior at the microstructural level, which can dictate the inelastic nonlinear deformation and fracture within the org…
View article: Artificial Intelligence for 3D Reconstruction from 2D Panoramic X-rays to Assess Maxillary Impacted Canines
Artificial Intelligence for 3D Reconstruction from 2D Panoramic X-rays to Assess Maxillary Impacted Canines Open
The objective of this study was to explore the feasibility of current 3D reconstruction in assessing the position of maxillary impacted canines from 2D panoramic X-rays. A dataset was created using pre-treatment CBCT data from a total of 1…
View article: The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli
The myosin and RhoGAP MYO9B influences osteocyte dendrite growth and responses to mechanical stimuli Open
Introduction: Myosin IXB (MYO9B) is an unconventional myosin with RhoGAP activity and thus is a regulator of actin cytoskeletal organization. MYO9B was previously shown to be necessary for skeletal growth and health and to play a role in a…
View article: Application of metal artifact reduction algorithm for CBCT diagnosis of temporary anchorage device–tooth root contact: inadequate to reduce false-positive rate
Application of metal artifact reduction algorithm for CBCT diagnosis of temporary anchorage device–tooth root contact: inadequate to reduce false-positive rate Open
Objectives: It was recently found that when cone beam computed tomography (CBCT) was used to examine temporary anchorage device (TAD)–tooth root contact, it tends to yield high false-positive (FP) diagnoses. This study investigated whether…
View article: Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes
Sexual dimorphism in bidirectional SR-mitochondria crosstalk in ventricular cardiomyocytes Open
Calcium transfer into the mitochondrial matrix during sarcoplasmic reticulum (SR) Ca 2+ release is essential to boost energy production in ventricular cardiomyocytes (VCMs) and match increased metabolic demand. Mitochondria from female hea…
View article: Supplementary Material for: Learning-Based Longitudinal Prediction Models for Mortality Risk in Very-Low-Birth-Weight Infants: A Nationwide Cohort Study
Supplementary Material for: Learning-Based Longitudinal Prediction Models for Mortality Risk in Very-Low-Birth-Weight Infants: A Nationwide Cohort Study Open
Introduction: Prediction models assessing the mortality of very-low-birth-weight (VLBW) infants were confined to models using only pre- and perinatal variables. We aimed to construct a prediction model comprising multifactorial clinical ev…
View article: Quantitative evaluation of training method in placing miniscrews in orthodontic graduate program
Quantitative evaluation of training method in placing miniscrews in orthodontic graduate program Open
Background The purpose of this study was to assess the effectiveness of training residents in an orthodontic program in the placement of miniscrews by using cone beam computed tomography (CBCT) images. A total of 90 miniscrews were placed …
View article: Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice
Characterization of Non-Invasively Induced Post-Traumatic Osteoarthritis in Mice Open
The pathophysiology of post-traumatic arthritis (PTOA) is not fully understood. This study used non-invasive repetitive mechanical loading (ML) mouse models to study biochemical, biomechanical, and pain-related behavioral changes induced i…
View article: Accuracy of three-dimensional printed models derived from cone-beam computed tomography
Accuracy of three-dimensional printed models derived from cone-beam computed tomography Open
Objectives To determine the accuracy of three-dimensional (3D) printed models fabricated from cone-beam computed tomography (CBCT) scans of human mandibular dry skulls in comparison with models derived from intraoral scanner (IOS) data. Ma…
View article: Compression generated by cortical screws in an artificial bone model of an equine medial femoral condylar cyst
Compression generated by cortical screws in an artificial bone model of an equine medial femoral condylar cyst Open
Objective Determine compression generated by lag and neutral screws over 12 h using two bone analogs. Study design Experimental study. Sample population Bone analogs were made of composite synthetic bone (CSB) or three‐dimensional printed …
View article: Aging Alters Cervical Vertebral Bone Density Distribution: A Cross-Sectional Study
Aging Alters Cervical Vertebral Bone Density Distribution: A Cross-Sectional Study Open
Osteoporosis reduces bone mineral density (BMD) with aging. The incidence of cervical vertebral injuries for the elderly has increased in the last decade. Thus, the objective of the current study was to examine whether dental cone beam com…
View article: Influence of dental implantation on bone mineral density distribution: a pilot study
Influence of dental implantation on bone mineral density distribution: a pilot study Open
The current findings suggested that receiving dental implants promoted oral bone mineralization for edentulous patients. The longitudinal investigation could provide valuable information on understanding the effects of implantation on the …
View article: Comparison of Dental Arch Width and Length Parameters in Patients With Obstructive Sleep Apnea and a Control Group: A Pilot Study
Comparison of Dental Arch Width and Length Parameters in Patients With Obstructive Sleep Apnea and a Control Group: A Pilot Study Open
Study Objective: Limited data suggest a smaller, narrow maxilla can lead to a decreased oropharyngeal volume (OPV).However, past studies have used two-dimensional lateral cephalometric radiographs.The specific aim of this study is to asses…
View article: Factors Associated with Mutations: Their Matching Rates to Cardiovascular and Neurological Diseases
Factors Associated with Mutations: Their Matching Rates to Cardiovascular and Neurological Diseases Open
Monogenic hypertension is rare and caused by genetic mutations, but whether factors associated with mutations are disease-specific remains uncertain. Given two factors associated with high mutation rates, we tested how many previously know…
View article: A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self‐Sustained Endochondral Ossification
A Biphasic Osteovascular Biomimetic Scaffold for Rapid and Self‐Sustained Endochondral Ossification Open
Regeneration of large bones remains a challenge in surgery. Recent developmental engineering efforts aim to recapitulate endochondral ossification (EO), a critical step in bone formation. However, this process entails the condensation of m…
View article: Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology
Alendronate-induced Perturbation of the Bone Proteome and Microenvironmental Pathophysiology Open
Objectives: Bisphosphonates (BPs) are powerful inhibitors of osteoclastogenesis and are used to prevent osteoporotic bone loss and reduce the risk of osteoporotic fracture in patients suffering from postmenopausal osteoporosis. Patients wi…
View article: Regulatory T Cells Conditioned Media Stimulates Migration in HaCaT Keratinocytes: Involvement of Wound Healing
Regulatory T Cells Conditioned Media Stimulates Migration in HaCaT Keratinocytes: Involvement of Wound Healing Open
Dongsoo Kim, Eunji Lo, Dongju Kim, Junghwa Kang Research &amp; Development, IMMUNISBIO CO. Ltd., B2, International ST. Mary&rsquo;s Hospital MTP Mall, Seo-gu, Incheon, KoreaCorrespondence: Junghwa KangResearch &amp; Development…