Dhananjaya S. Kulkarni
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View article: The structure of the MutL-CTD:processivity-clamp complex provides insight regarding strand discrimination in non-methyl-directed DNA mismatch repair
The structure of the MutL-CTD:processivity-clamp complex provides insight regarding strand discrimination in non-methyl-directed DNA mismatch repair Open
Many prokaryotes, including members of the Neisseria species, lack MutH and cannot employ methyl-directed DNA mismatch repair (MMR). The nick on the daughter strand is created by the endonuclease activity present in the C-terminal domain (…
View article: Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis
Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis Open
During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this …
View article: Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis
Distinct and interdependent functions of three RING proteins regulate recombination during mammalian meiosis Open
During meiosis, each pair of homologous chromosomes becomes connected by at least one crossover, as required for accurate segregation, and adjacent crossovers are widely separated thereby limiting total numbers. In coarsening models, this …
View article: SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over
SUMO fosters assembly and functionality of the MutSγ complex to facilitate meiotic crossing over Open
View article: PCNA activates the MutLγ endonuclease to promote meiotic crossing over
PCNA activates the MutLγ endonuclease to promote meiotic crossing over Open
View article: Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse
Proline-rich protein PRR19 functions with cyclin-like CNTD1 to promote meiotic crossing over in mouse Open
View article: Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over
Regulated Proteolysis of MutSγ Controls Meiotic Crossing Over Open
View article: PCNA activates the MutLγ endonuclease to promote meiotic crossing over
PCNA activates the MutLγ endonuclease to promote meiotic crossing over Open
During meiosis, crossover recombination connects homologous chromosomes to direct their accurate segregation 1 . Defects in crossing over cause infertility, miscarriage and congenital disease. Accordingly, each pair of chromosomes attains …
View article: The crossover function of MutSγ is activated via Cdc7-dependent stabilization of Msh4
The crossover function of MutSγ is activated via Cdc7-dependent stabilization of Msh4 Open
SUMMARY The MutSγ complex, Msh4-Msh5, binds DNA joint-molecule (JM) intermediates during homologous recombination to promote crossing over and accurate chromosome segregation at the first division of meiosis. MutSγ facilitates the formatio…
View article: Mechanism of formation of a toroid around DNA by the mismatch sensor protein
Mechanism of formation of a toroid around DNA by the mismatch sensor protein Open
The DNA mismatch repair (MMR) pathway removes errors that appear during genome replication. MutS is the primary mismatch sensor and forms an asymmetric dimer that encircles DNA to bend it to scan for mismatches. The mechanism utilized to l…