Dinesh Babu
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View article: ELF4 bridges transcriptional and translational outputs to regulate inflammatory T Cells 3617
ELF4 bridges transcriptional and translational outputs to regulate inflammatory T Cells 3617 Open
Description The transcription factor ELF4 generally acts as a brake on the immune system, as patients with Deficiency in ELF4 X-linked (DEX) exhibit symptoms of hyperinflammation. While it has been demonstrated by our lab that global loss …
View article: A chemoproteomic strategy for identifying protein covalent binding targets of clozapine: An approach for advancing clozapine toxicity research
A chemoproteomic strategy for identifying protein covalent binding targets of clozapine: An approach for advancing clozapine toxicity research Open
Schizophrenia affects a significant proportion of individuals, wherein a subset of patients is described as treatment-resistant. Clozapine (CLOZ) is an atypical antipsychotic, which is reserved for these patients and is superior in its ant…
View article: Lipid-Polymer Hybrid Nanoparticles for Solubility Enhancement of Tetrahydrocurcumin in a Noval Discriminative Dissolution Medium
Lipid-Polymer Hybrid Nanoparticles for Solubility Enhancement of Tetrahydrocurcumin in a Noval Discriminative Dissolution Medium Open
A promising strategy to overcome the problems in treatment with pharmaceutical active ingredients involves the development of suitable drug carrier systems using nanoparticles (NPs). Tetrahydrocurcumin (THC) is an active metabolite of curc…
View article: Uncommon Presentations of Axillary Artery Aneurysm
Uncommon Presentations of Axillary Artery Aneurysm Open
Background: Axillary artery aneurysms are rare compared to other peripheral aneurysms. Once developed, they can cause vascular complications like rupture, thromboembolism leading to gangrene, limb loss or neurologic complications due to th…
View article: Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs
Investigating emodin derivatives against SARS-CoV-2 found in medicinal herbs Open
SARS-CoV-2 continues to mutate and circulate at alarming levels around the world and is exemplified by the emergence of the new variant JN.1. The emergence of novel SARS-CoV variants underscores the urgency for the development of new drugs…
View article: Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs
Efficient deletion of microRNAs using CRISPR/Cas9 with dual guide RNAs Open
MicroRNAs (miRNAs) are short non-coding RNAs that play crucial roles in gene regulation, exerting post-transcriptional silencing, thereby influencing cellular function, development, and disease. Traditional loss-of-function methods for stu…
View article: Peer Review #3 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.2)"
Peer Review #3 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.2)" Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities.This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, …
View article: Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.2)"
Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.2)" Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities.This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, …
View article: Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.4)"
Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.4)" Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities.This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, …
View article: A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of <i>Momordica cymbalaria</i> Hook F
A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of <i>Momordica cymbalaria</i> Hook F Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities. This detailed, comprehensive review gathers and presents all the information related to the geographical distribution,…
View article: Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.3)"
Peer Review #2 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.3)" Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities.This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, …
View article: Peer Review #3 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.3)"
Peer Review #3 of "A review on the traditional uses, nutritive importance, pharmacognostic features, phytochemicals, and pharmacology of Momordica cymbalaria Hook F (v0.3)" Open
Momordica cymbalaria Hook F. (MC), belonging to the family Cucurbitaceae, is a plant with several biological activities.This detailed, comprehensive review gathers and presents all the information related to the geographical distribution, …
View article: The immunological activities and transcriptome analysis of a potent small-molecule immunomodulator
The immunological activities and transcriptome analysis of a potent small-molecule immunomodulator Open
The use of small molecules in immunotherapy is a promising and rapidly growing field with the potential to revolutionize the way we treat a wide range of immunological diseases. The success stories of using small molecules in immunotherapy…
View article: Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy
Adenosine triphosphate induced cell death: Mechanisms and implications in cancer biology and therapy Open
Adenosine triphosphate ( ATP) induced cell death (AICD) is a critical cellular process that has garnered substantial scientific interest for its profound relevance to cancer biology and to therapeutic interventions. This comprehensive revi…
View article: Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression
Efficient gene editing in induced pluripotent stem cells enabled by an inducible adenine base editor with tunable expression Open
The preferred method for disease modeling using induced pluripotent stem cells (iPSCs) is to generate isogenic cell lines by correcting or introducing pathogenic mutations. Base editing enables the precise installation of point mutations a…
View article: Proof of concept: Pull down assay using bovine serum albumin and an immunomodulator small molecule
Proof of concept: Pull down assay using bovine serum albumin and an immunomodulator small molecule Open
View article: Target identification of small molecules: an overview of the current applications in drug discovery
Target identification of small molecules: an overview of the current applications in drug discovery Open
View article: The oxidation of fenamic acid NSAIDs by neutrophil myeloperoxidase produces toxic reactive metabolites that induce leukemic cell death
The oxidation of fenamic acid NSAIDs by neutrophil myeloperoxidase produces toxic reactive metabolites that induce leukemic cell death Open
Fenamic acids are a group of non-steroidal anti-inflammatory drugs (NSAIDs) that are among the most common drugs prescribed globally. However, they have been associated with many adverse effects, such as agranulocytosis, neutropenia, hepat…
View article: Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21<sup>st</sup> century: A systematic review
Acknowledging the use of botanicals to treat diabetic foot ulcer during the 21<sup>st</sup> century: A systematic review Open
The validation of mechanisms of action underlying these phytocompounds contributing to the management of DFU can aid in our better understanding of creating efficient treatment options for DFU and its associated problems.
View article: Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells
Inhibition of BCR::ABL1 tyrosine kinase activity Aids in the Generation of Stable Chronic Myeloid Leukemia Induced Pluripotent Stem Cells Open
Induced pluripotent stem cells (iPSCs) generated from patients with chronic myeloid leukemia (CML) have the potential for disease modeling to study disease pathogenesis and screening therapeutic interventions. In this study, we aimed to ge…
View article: Influence of temperature and thermal cycles on the corrosion mechanism of wrought AZ91D magnesium alloy in simulated sea water solution
Influence of temperature and thermal cycles on the corrosion mechanism of wrought AZ91D magnesium alloy in simulated sea water solution Open
This study successfully conducted a comprehensive analysis of the AZ91D magnesium alloy, encompassing micro-structural, mechanical, and corrosion assessments. The microstructure consisted of primary α-Mg crystals and an aluminum-rich α-Mg/…
View article: The Anticancer Potential of Psidium guajava (Guava) Extracts
The Anticancer Potential of Psidium guajava (Guava) Extracts Open
The fruits, leaves, and bark of the guava (Psidium guajava) tree have traditionally been used to treat a myriad of ailments, especially in the tropical and subtropical regions. The various parts of the plant have been shown to exhibit medi…
View article: Clinical Profile and Factors Associated with Adverse Outcomes in Coronavirus Disease 2019-associated Mucormycosis: A Single-centre Study
Clinical Profile and Factors Associated with Adverse Outcomes in Coronavirus Disease 2019-associated Mucormycosis: A Single-centre Study Open
Background: The coronavirus disease 2019 (COVID-19) pandemic was associated with an increased incidence of mucormycosis globally. However, the clinical pattern, epidemiologic features and risk factors for adverse outcomes are not well esta…
View article: The Effect of Aflatoxin B1 on Tumor-Related Genes and Phenotypic Characters of MCF7 and MCF10A Cells
The Effect of Aflatoxin B1 on Tumor-Related Genes and Phenotypic Characters of MCF7 and MCF10A Cells Open
The fungal toxin aflatoxin B1 (AB1) and its reactive intermediate, aflatoxin B1-8, 9 epoxide, could cause liver cancer by inducing DNA adducts. AB1 exposure can induce changes in the expression of several cancer-related genes. In this stud…
View article: Pseudotumor cerebri presenting with 2nd and 7th nerve palsy
Pseudotumor cerebri presenting with 2nd and 7th nerve palsy Open
Idiopathic intracranial hypertension, alternatively called pseudotumor cerebri is characterized by increased intracranial pressure of unknown pathology with the absence of any structural lesions.This intracranial hypertension most commonly…
View article: Guillain–barré syndrome without limb weakness: A rare variant with acute bulbar palsy
Guillain–barré syndrome without limb weakness: A rare variant with acute bulbar palsy Open
A 76-year-old male was brought to the emergency room with an acute onset of breathlessness and difficulty swallowing. Examination revealed bilateral ptosis, bilateral vocal cord abductor palsy with diaphragmatic paralysis. He did not have …
View article: Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study
Effectiveness of BBV152/Covaxin and AZD1222/Covishield vaccines against severe COVID-19 and B.1.617.2/Delta variant in India, 2021: a multi-centric hospital-based case-control study Open
View article: Hybrid Assembly and Annotation of the Genome of the Indian Punica granatum, a Superfood
Hybrid Assembly and Annotation of the Genome of the Indian Punica granatum, a Superfood Open
The wonder fruit pomegranate ( Punica granatum , family Lythraceae) is one of India’s economically important fruit crops that can grow in different agro-climatic conditions ranging from tropical to temperate regions. This study reports hig…
View article: Self-nanoemulsifying drug delivery system of aqueous leaf extracts of Justicia adhatoda and Psidium guajava to enhance platelet count
Self-nanoemulsifying drug delivery system of aqueous leaf extracts of Justicia adhatoda and Psidium guajava to enhance platelet count Open
View article: Hepatoprotective activity of the ethanolic extract of Morus indica roots from Indian Bodo tribes
Hepatoprotective activity of the ethanolic extract of Morus indica roots from Indian Bodo tribes Open