Dharmatma Singh
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View article: The impact of inflammatory bowel disease on women’s health: a cross sectional study in India
The impact of inflammatory bowel disease on women’s health: a cross sectional study in India Open
IBD affects women across physical, reproductive, social, and financial domains. Culturally sensitive, multidisciplinary care models are essential to address these unmet needs.
View article: A Study of Correlation of Expression of Er, Pr & Her2neu Receptor Status with the Clinico-pathological Prognostic Factor in Breast Carcinoma
A Study of Correlation of Expression of Er, Pr & Her2neu Receptor Status with the Clinico-pathological Prognostic Factor in Breast Carcinoma Open
BACKGROUND: Breast cancer is the most common malignancy in females. It is routinely classified according to the WHO classification. However molecular classification can be more powerful than histopathology as a predictive factor for the di…
View article: Clinical spectrum of acute severe ulcerative colitis in the biologic era: a prospective cohort study from India
Clinical spectrum of acute severe ulcerative colitis in the biologic era: a prospective cohort study from India Open
In this cohort of ASUC patients, poor treatment compliance, antibiotic use, stress, and C. difficile infection were common precipitants of flare-ups. Nearly one-third of patients required medical rescue therapy, and a small proportion ulti…
View article: P0881 Effectiveness and Safety of Tofacitinib in Biologic-Naïve Elderly Patients with Ulcerative Colitis
P0881 Effectiveness and Safety of Tofacitinib in Biologic-Naïve Elderly Patients with Ulcerative Colitis Open
Background The prevalence of ulcerative colitis (UC) is increasing in elderly populations, yet real-world data on the efficacy and safety of tofacitinib in this demographic remains limited. This study aimed to evaluate the real-world effec…
View article: P0923 Impact of Inflammatory Bowel Disease on Women’s Health
P0923 Impact of Inflammatory Bowel Disease on Women’s Health Open
Background Inflammatory bowel disease presents chronic challenges that disrupt physical well-being and create significant psychosocial stressors. Despite known gender-specific issues, data on how IBD affects women, particularly in a socio-…
View article: P1098 The Clinical Spectrum of Acute Severe Ulcerative Colitis in the Biologic Era
P1098 The Clinical Spectrum of Acute Severe Ulcerative Colitis in the Biologic Era Open
Background Acute severe ulcerative colitis (ASUC) is a time critical situation requiring urgent intervention. Limited data exist on the evolving clinical spectrum of ASUC in the era of advanced therapies. Methods This prospective cohort st…
View article: Predictive accuracy of fecal calprotectin for histologic remission in ulcerative colitis
Predictive accuracy of fecal calprotectin for histologic remission in ulcerative colitis Open
Background/Aims: Accurate assessment of disease activity is crucial for effective management and treatment of ulcerative colitis (UC). This study evaluated the correlation between clinical, endoscopic, and histologic measures of disease ac…
View article: P847 Effectiveness of tofacitinib in ulcerative proctitis compared to left sided colitis and pancolitis
P847 Effectiveness of tofacitinib in ulcerative proctitis compared to left sided colitis and pancolitis Open
Background Ulcerative proctitis (UP), though associated with high symptom burden and poor quality of life, is excluded from most of the randomized controlled trials in UC. We aimed to analyse the effectiveness of tofacitinib in UP, and com…
View article: P1210 Gut microbiota profiling and disease course in patients with ulcerative colitis in clinical remission
P1210 Gut microbiota profiling and disease course in patients with ulcerative colitis in clinical remission Open
Background The inflammatory bowel diseases, encompassing ulcerative colitis (UC) and Crohn’s disease (CD) are characterized by a relapsing-remitting disease course. Despite achieving remission, approximately one-third of the patients relap…
View article: Tofacitinib Versus Oral Prednisolone for Induction of Remission in Moderately Active Ulcerative Colitis [ORCHID]: A Prospective, Open-Label, Randomized, Pilot Study
Tofacitinib Versus Oral Prednisolone for Induction of Remission in Moderately Active Ulcerative Colitis [ORCHID]: A Prospective, Open-Label, Randomized, Pilot Study Open
Background Oral corticosteroids are first-line agents to induce remission in moderately active ulcerative colitis [UC], but are associated with adverse effects. We compared the efficacy and safety of tofacitinib and prednisolone for induct…
View article: Enrichment of Lactic Acid-Producing Bacteria in the Fecal Microbiota of Patients with Ulcerative Colitis in North India
Enrichment of Lactic Acid-Producing Bacteria in the Fecal Microbiota of Patients with Ulcerative Colitis in North India Open
Previous studies have established the relationship between the gut microbiota and ulcerative colitis (UC); however, there is a scarcity of data on the fecal microbiome profile of patients with UC in the Indian population. This study aimed …
View article: DOP44 Tofacitinib versus corticosteroids for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective randomized open-label pilot study
DOP44 Tofacitinib versus corticosteroids for induction of remission in moderately active ulcerative colitis (ORCHID): A prospective randomized open-label pilot study Open
Background The exact positioning of tofacitinib in the therapeutic algorithm is still unclear. We evaluated the efficacy of tofacitinib in comparison to corticosteroids for induction of remission in patients with moderately active UC. Meth…
View article: Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD
Inflammatory bowel disease (IBD)-disk accurately predicts the daily life burden and parallels disease activity in patients with IBD Open
Background/Aims: The inflammatory bowel disease (IBD)-disk is a validated, visual, 10-item, self-administered questionnaire used to evaluate IBD-related disability. The present study aimed to evaluate IBD-disk in assessment of IBD daily li…
View article: Clinical spectrum of elderly-onset inflammatory bowel disease in India
Clinical spectrum of elderly-onset inflammatory bowel disease in India Open
Background/Aims: Inflammatory bowel disease (IBD) is increasingly being recognized in elderly patients. Data on clinical spectrum of elderly-onset IBD patients is lacking from India.Methods: A cross-sectional retrospective analysis of a pr…
View article: Correlation between faecal microbial taxa and ulcerative colitis in different phases of disease activity in a north Indian cohort
Correlation between faecal microbial taxa and ulcerative colitis in different phases of disease activity in a north Indian cohort Open
Background and Aims A link between gut microbiota and Ulcerative colitis (UC) has been established in several studies. However, only a few studies have examined specific changes in microbiota associated with different phases of disease act…
View article: Maintaining infliximab induced clinical remission with azathioprine and 5-aminosalicylates in acute severe steroid-refractory ulcerative colitis has lower cost and high efficacy (MIRACLE): a multicenter study
Maintaining infliximab induced clinical remission with azathioprine and 5-aminosalicylates in acute severe steroid-refractory ulcerative colitis has lower cost and high efficacy (MIRACLE): a multicenter study Open
Background/Aims: Infliximab (IFX) has been used to induce and maintain remission in patients with severe steroid-refractory ulcerative colitis (UC). Long-term use of biologics in developing countries is limited by high cost and frequent si…
View article: Trends of inflammatory bowel disease at a tertiary care center in northern India
Trends of inflammatory bowel disease at a tertiary care center in northern India Open
Background/Aims: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn’s disease (CD), is increasingly being reported from India and other Asian countries. This study looks into the changing trends of IBD at a terti…
View article: Clinical Predictors of Response to Faecal Microbiota Transplantation in Patients with Active Ulcerative Colitis
Clinical Predictors of Response to Faecal Microbiota Transplantation in Patients with Active Ulcerative Colitis Open
Background Faecal microbiota transplantation [FMT] has been shown to be effective for induction of remission in patients with active ulcerative colitis [UC]. At present, the clinical factors impacting the response to FMT in UC remain uncle…
View article: Incidental benefits after fecal microbiota transplant for ulcerative colitis
Incidental benefits after fecal microbiota transplant for ulcerative colitis Open
Gut dysbiosis can result in several diseases, including infections (Clostridium difficile infection and infectious gastroenteritis), autoimmune diseases (inflammatory bowel disease, diabetes, and allergic disorders), behavioral disorders a…
View article: P358 Predictors of response to faecal microbiota transplantation in patients with active ulcerative colitis
P358 Predictors of response to faecal microbiota transplantation in patients with active ulcerative colitis Open
Background Faecal microbiota transplantation (FMT) has been shown to be effective for induction of remission in nearly 50% patients with active UC. At present, factors impacting the response to FMT in UC remain unclear. Methods Patients wi…
View article: Impact of "Sambhav" Program (Financial Assistance and Counselor Services) on Hepatitis C Pegylated Interferon Alpha Treatment Initiation in India
Impact of "Sambhav" Program (Financial Assistance and Counselor Services) on Hepatitis C Pegylated Interferon Alpha Treatment Initiation in India Open
'Sambhav' program had significant impact on the initiation of antiviral therapy by overcoming the financial hurdles. The free counselor services helped to mitigate social taboos and imparted adequate awareness about the disease to the pati…