Dhélio B. Pereira
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View article: Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp.
Evaluation of the Activity of 4-Quinolones against Multi-Life Stages of <i>Plasmodium</i> spp. Open
Malaria is a critical global health problem, with high mortality and morbidity rates, which ultimately hinder socioeconomic development in endemic areas. The evolution of drug resistance in malaria parasites, particularly in the case of
View article: Fluorescent Marinoquinoline Derivative as Inhibitors of <i>Plasmodium falciparum</i> : SAR Analysis, Mode of Action and In Vivo Studies
Fluorescent Marinoquinoline Derivative as Inhibitors of <i>Plasmodium falciparum</i> : SAR Analysis, Mode of Action and In Vivo Studies Open
We present insights into the mechanism of action of marinoquinolines (MQ), a novel class of lead candidates. Using a divergent synthetic approach, we developed a series of 20 new analogues with fluorescence properties. Structure-activity r…
View article: Indole-2-carboxamides Optimization for Antiplasmodial Activity
Indole-2-carboxamides Optimization for Antiplasmodial Activity Open
Malaria still stands out as one of the most devastating and prevalent diseases globally, where the rise of resistance to different antimalarial drugs in different regions has posed significant obstacles to global treatment and elimination.…
View article: Perceptions of persons deprived of liberty regarding tuberculosis vaccine research
Perceptions of persons deprived of liberty regarding tuberculosis vaccine research Open
Background Several tuberculosis (TB) vaccine candidates are currently advancing to late stage clinical trials. Prisons in low- and middle-income countries harbor some of the highest rates of TB in the world, making persons deprived of libe…
View article: Identification of cross-stage, cross-species malaria CD8+ T cell antigens
Identification of cross-stage, cross-species malaria CD8+ T cell antigens Open
Malaria is one of the most prevalent parasitic diseases in the world. In 2023, 263 million malaria cases were estimated worldwide. Two species of Plasmodium, P. falciparum and P. vivax, cause most human malaria. Despite the licensing of tw…
View article: Percepções de pessoas de áreas endêmicas de malária sobre desafios e barreiras para testagem
Percepções de pessoas de áreas endêmicas de malária sobre desafios e barreiras para testagem Open
Objetivo- Explorar o ponto de vista dos residentes nas comunidades de Porto Velho e vizinhas sobre testes de malária, riscos e benefícios relacionados. Metodologia- Apreciação rápida e participativa das necessidades da comunidade por meio …
View article: Marine Guanidine Alkaloids Inhibit Malaria Parasites Development in <i>In Vitro</i>, <i>In Vivo</i> and <i>Ex Vivo</i> Assays
Marine Guanidine Alkaloids Inhibit Malaria Parasites Development in <i>In Vitro</i>, <i>In Vivo</i> and <i>Ex Vivo</i> Assays Open
Malaria is a disease caused by pathogenic protozoa Plasmodium spp., with a significant global impact on human health. Increasing resistance of P. falciparum strains to drugs treating malaria highlights the urgent need for the…
View article: Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis
Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis Open
Background Parasite density thresholds used for diagnosing symptomatic malaria are defined by the relationship between parasitaemia and fever. This relationship can inform the design and development of novel diagnostic tests but appropriat…
View article: Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity
Asymptomatic vivax malaria is associated with an IFN-γ-program on adaptive immunity Open
View article: An observational pilot study of an active surveillance tool to enhance pharmacovigilance in Brazil
An observational pilot study of an active surveillance tool to enhance pharmacovigilance in Brazil Open
View article: Safety and Efficacy of 3 Alternative Regimens Against Relapsing <i>Plasmodium vivax</i> Malaria in Glucose 6-Phosphate Dehydrogenase–Deficient Patients in the Brazilian Amazon (ALTPRIM)
Safety and Efficacy of 3 Alternative Regimens Against Relapsing <i>Plasmodium vivax</i> Malaria in Glucose 6-Phosphate Dehydrogenase–Deficient Patients in the Brazilian Amazon (ALTPRIM) Open
Background Daily primaquine-induced hemolysis is a common cause of complications during Plasmodium vivax malaria treatment in individuals with glucose 6-phosphate dehydrogenase deficiency (G6PDd). Alternative regimens balancing safety and …
View article: Modernization of Brazil’s Clinical Research Environment: Important Steps Are Underway
Modernization of Brazil’s Clinical Research Environment: Important Steps Are Underway Open
View article: Identification of potential bi-triazole based antimalarial compounds and their effects against asexual stages of Plasmodium isolates
Identification of potential bi-triazole based antimalarial compounds and their effects against asexual stages of Plasmodium isolates Open
Malaria is a parasitic infection that can become severe and lead to a patient’s death, besides having records of resistance to treatment and only a few options to treat it, generating the need for more research on new antimalarial compound…
View article: Assessing tafenoquine implementation in Brazil: a qualitative evaluation of perceptions of healthcare providers and Plasmodium vivax patients (QualiTRuST Study)
Assessing tafenoquine implementation in Brazil: a qualitative evaluation of perceptions of healthcare providers and Plasmodium vivax patients (QualiTRuST Study) Open
View article: A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo
A potent and selective reaction hijacking inhibitor of Plasmodium falciparum tyrosine tRNA synthetase exhibits single dose oral efficacy in vivo Open
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase ( Pf TyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidi…
View article: Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission
Inhibitors of malaria parasite cyclic nucleotide phosphodiesterases block asexual blood-stage development and mosquito transmission Open
Cyclic nucleotide–dependent phosphodiesterases (PDEs) play essential roles in regulating the malaria parasite life cycle, suggesting that they may be promising antimalarial drug targets. PDE inhibitors are used safely to treat a range of n…
View article: OR-17 - AVALIAÇÃO DA ATIVIDADE DE G6PD E SUAS CARACTERÍSTICAS EPIDEMIOLÓGICAS EM INDIVÍDUOS COM DIAGNÓSTICO DE MALÁRIA
OR-17 - AVALIAÇÃO DA ATIVIDADE DE G6PD E SUAS CARACTERÍSTICAS EPIDEMIOLÓGICAS EM INDIVÍDUOS COM DIAGNÓSTICO DE MALÁRIA Open
Introdução: A deficiência de glicose-6-fosfato desidrogenase (G6PD) afeta cerca de 400 milhões de pessoas no mundo, na Amazônia brasileira foi descrita uma prevalência de 5,6%. É uma desordem enzimática, e torna a hemácia suscetível à injú…
View article: EP-001 - DESCRIÇÃO DAS CARACTERÍSTICAS CLÍNICAS EM PACIENTES INTERNADOS COM METAEMOGLOBINEMIA
EP-001 - DESCRIÇÃO DAS CARACTERÍSTICAS CLÍNICAS EM PACIENTES INTERNADOS COM METAEMOGLOBINEMIA Open
Introdução: A malária é uma das doenças infecto-parasitárias de maior importância no mundo. A metahemoglobinemia é uma das principais complicações relacionada a terapêutica medicamentosa para o P. vivax com derivados 8-aminoquinolinas, com…
View article: OR-18 - ANÁLISE DA PREVALÊNCIA DE METAHEMOGLOBINA, SEUS NÍVEIS E MANIFESTAÇÕES CLÍNICAS
OR-18 - ANÁLISE DA PREVALÊNCIA DE METAHEMOGLOBINA, SEUS NÍVEIS E MANIFESTAÇÕES CLÍNICAS Open
Introdução: Visando diminuir recaídas, o tratamento da malária foi modificado aumentando a dose diária da primaquina e reduzindo o tempo de tratamento. Essa estratégia parece ter aumentado episódios de metahemoglobinemia, ações oxidantes n…
View article: A potent and selective reaction hijacking inhibitor of<i>Plasmodium falciparum</i>tyrosine tRNA synthetase exhibits single dose oral efficacy<i>in vivo</i>
A potent and selective reaction hijacking inhibitor of<i>Plasmodium falciparum</i>tyrosine tRNA synthetase exhibits single dose oral efficacy<i>in vivo</i> Open
The Plasmodium falciparum cytoplasmic tyrosine tRNA synthetase ( Pf TyrRS) is an attractive drug target that is susceptible to reaction-hijacking by AMP-mimicking nucleoside sulfamates. We previously identified an exemplar pyrazolopyrimidi…
View article: Monoamine oxidase-A (MAO-A) low-expression variants and increased risk of <i>Plasmodium vivax</i> malaria relapses
Monoamine oxidase-A (MAO-A) low-expression variants and increased risk of <i>Plasmodium vivax</i> malaria relapses Open
Objectives Primaquine is essential for the radical cure of Plasmodium vivax malaria and must be metabolized into its bioactive metabolites. Accordingly, polymorphisms in primaquine-metabolizing enzymes can impact the treatment efficacy. Th…
View article: Perspectives of healthcare professionals on training for quantitative G6PD testing during implementation of tafenoquine in Brazil (QualiTRuST Study)
Perspectives of healthcare professionals on training for quantitative G6PD testing during implementation of tafenoquine in Brazil (QualiTRuST Study) Open
Effective radical cure of Plasmodium vivax malaria is essential for malaria elimination in Brazil. P . vivax radical cure requires administration of a schizonticide, such as chloroquine, plus an 8-aminoquinoline. However, 8-aminoquinolines…
View article: Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis
Parasitaemia and fever in uncomplicated Plasmodium vivax malaria: a systematic review and individual patient data meta-analysis Open
Background Parasite density thresholds for diagnosing symptomatic malaria are defined by the relationship between parasitaemia and fever; they inform the development of novel diagnostic tests. Thresholds for diagnosing Plasmodium vivax mal…
View article: Operational effectiveness of tafenoquine and primaquine for the prevention of Plasmodium vivax recurrence in Brazil: a retrospective observational study
Operational effectiveness of tafenoquine and primaquine for the prevention of Plasmodium vivax recurrence in Brazil: a retrospective observational study Open
For the Portuguese translation of the abstract see Supplementary Materials section.
View article: Operational feasibility of Plasmodium vivax radical cure with tafenoquine or primaquine following point-of-care, quantitative glucose-6-phosphate dehydrogenase testing in the Brazilian Amazon: a real-life retrospective analysis
Operational feasibility of Plasmodium vivax radical cure with tafenoquine or primaquine following point-of-care, quantitative glucose-6-phosphate dehydrogenase testing in the Brazilian Amazon: a real-life retrospective analysis Open
View article: Outbreak of Oropouche virus in frontier regions in western Amazon
Outbreak of Oropouche virus in frontier regions in western Amazon Open
Oropouche virus (OROV) is characterized as a re-emerging arbovirus of great concern for public health, being responsible for several outbreaks of acute fever identified in Latin American countries, registering more than half a million repo…
View article: Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis
Clinical performance validation of the STANDARD G6PD test: A multi-country pooled analysis Open
Introduction Screening for G6PD deficiency can inform disease management including malaria. Treatment with the antimalarial drugs primaquine and tafenoquine can be guided by point-of-care testing for G6PD deficiency. Methods and findings D…
View article: Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis
Effect of adherence to primaquine on the risk of Plasmodium vivax recurrence: a WorldWide Antimalarial Resistance Network systematic review and individual patient data meta-analysis Open
Background Imperfect adherence is a major barrier to effective primaquine radical cure of Plasmodium vivax . This study investigated the effect of reduced adherence on the risk of P. vivax recurrence. Methods Efficacy studies of patients w…
View article: Integration of serial self-testing for COVID-19 as part of contact tracing in the Brazilian public health system: A pragmatic trial protocol
Integration of serial self-testing for COVID-19 as part of contact tracing in the Brazilian public health system: A pragmatic trial protocol Open
The coronavirus disease (COVID-19) pandemic has led to an unprecedented public health crisis. Insufficient testing continues to limit the effectiveness of the global response to the COVID-19 pandemic. Molecular testing methods such as reve…
View article: Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis
Effect of primaquine dose on the risk of recurrence in patients with uncomplicated Plasmodium vivax: a systematic review and individual patient data meta-analysis Open