Dhiraj G. Kabra
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View article: A UV Spectroscopic Method for Simultaneous Estimation of Rosuvastatin and Teneligliptin from Bulk and Pharmaceutical Formulation
A UV Spectroscopic Method for Simultaneous Estimation of Rosuvastatin and Teneligliptin from Bulk and Pharmaceutical Formulation Open
View article: HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice
HDAC5 controls a hypothalamic STAT5b-TH axis, the sympathetic activation of ATP-consuming futile cycles and adult-onset obesity in male mice Open
View article: Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity
Type 2 diabetes risk gene Dusp8 regulates hypothalamic Jnk signaling and insulin sensitivity Open
Recent genome-wide association studies (GWAS) identified DUSP8, encoding a dual-specificity phosphatase targeting mitogen-activated protein kinases, as a type 2 diabetes (T2D) risk gene. Here, we reveal that Dusp8 is a gatekeeper in the hy…
View article: Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle
Histone deacetylase 5 regulates interleukin 6 secretion and insulin action in skeletal muscle Open
View article: Functional identity of hypothalamic melanocortin neurons depends on Tbx3
Functional identity of hypothalamic melanocortin neurons depends on Tbx3 Open
View article: Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456–2465
Erratum. Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1. Diabetes 2018;67:2456–2465 Open
In the article listed above, ERX was erroneously omitted from the duality of interest for Matthias H. …
View article: Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1 Open
Celastrol, a plant-derived constituent of traditional Chinese medicine, has been proposed to offer significant potential as an antiobesity drug. However, the molecular mechanism for this activity is unknown. We show that the weight-lowerin…
View article: FGF21 regulates insulin sensitivity following long-term chronic stress
FGF21 regulates insulin sensitivity following long-term chronic stress Open
Early-life exposure to chronic stress leads to long term improvements in insulin sensitivity, oxidative metabolism and adipose tissue remodeling. FGF21 contributes to a physiological memory mechanism to maintain metabolic homeostasis.
View article: Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice
Calcineurin A beta deficiency ameliorates HFD-induced hypothalamic astrocytosis in mice Open
ᅟ: Astrocytosis is a reactive process involving cellular, molecular, and functional changes to facilitate neuronal survival, myelin preservation, blood brain barrier function and protective glial scar formation upon brain insult. The overa…
View article: Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress
Absence of the kinase S6k1 mimics the effect of chronic endurance exercise on glucose tolerance and muscle oxidative stress Open
In high-fat fed mice, loss of S6K1 mimics endurance exercise training by reducing mitochondrial ROS production and upregulating oxidative utilization of ketone bodies. Pharmacological targeting of S6K1 may improve the outcome of exercise-b…
View article: Hypothalamic leptin action is mediated by histone deacetylase 5
Hypothalamic leptin action is mediated by histone deacetylase 5 Open
View article: Calcineurin Links Mitochondrial Elongation with Energy Metabolism
Calcineurin Links Mitochondrial Elongation with Energy Metabolism Open
View article: Tachykinin-1 in the Central Nervous System Regulates Adiposity in Rodents
Tachykinin-1 in the Central Nervous System Regulates Adiposity in Rodents Open
Ghrelin is a circulating hormone that targets the central nervous system to regulate feeding and adiposity. The best-characterized neural system that mediates the effects of ghrelin on energy balance involves the activation of neuropeptide…