Dhiraj Kumar Singh
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View article: Resource modeling and adaptive strategies for sustainable rice production in flood-prone regions: a case study in West Bengal, India
Resource modeling and adaptive strategies for sustainable rice production in flood-prone regions: a case study in West Bengal, India Open
View article: Comparative Evaluation Of Axiostat Vs . Gelfoam For Post-Extraction Hemostasis And Healing In Patients On Antiplatelet Therapy: A Clinical Study
Comparative Evaluation Of Axiostat Vs . Gelfoam For Post-Extraction Hemostasis And Healing In Patients On Antiplatelet Therapy: A Clinical Study Open
Objectives: To evaluate the effectiveness of Axiostat Hemostatic Dental (AHD) dressing compared to Gelfoam in achieving hemostasis and promoting healing following mandibular tooth extractions in patients on antiplatelet therapy. Materials …
View article: Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines
Development and preclinical evaluation of next-generation ΔsigH-based live candidate vaccines Open
To radically diminish tuberculosis (TB) incidence and mortality by 2035, as set out by the WHO End TB Strategy, there is a desperate need for improved TB therapies and a more effective vaccine against the deadly pathogen Mycobacterium tube…
View article: Single-cell transcriptome analysis of bronchoalveolar lavage during early SARS-CoV-2 infection
Single-cell transcriptome analysis of bronchoalveolar lavage during early SARS-CoV-2 infection Open
The COVID-19 pandemic, triggered by the SARS-CoV-2 virus, has led to global consequences since its emergence in late 2019, impacting health, economies, and societies worldwide. Understanding the early responses following infection will pro…
View article: An evaluation of pansharpening algorithms on Worldview-4 satellite imagery over Western Himalaya
An evaluation of pansharpening algorithms on Worldview-4 satellite imagery over Western Himalaya Open
View article: Increased vaccine efficacy against tuberculosis with a recombinant BCG overexpressing the STING agonist cyclic di-AMP.
Increased vaccine efficacy against tuberculosis with a recombinant BCG overexpressing the STING agonist cyclic di-AMP. Open
Tuberculosis (TB) remains the leading cause of death due to infection globally. Bacillus Calmette Guérin (BCG), a live attenuated bacterial strain, is the only available TB vaccine, but it has poor efficacy in preventing pulmonary TB in ad…
View article: Anterior And Posterior Interbody Fusion With Multilevel Fixation For Lumbar Potts Spine: A Novel Approach
Anterior And Posterior Interbody Fusion With Multilevel Fixation For Lumbar Potts Spine: A Novel Approach Open
Spinal tuberculosis, also known as Pott’s spine, represents up to 50% of skeletal tuberculosis cases, with a rising prevalence in endemic regions. This case report details a 19-year-old male who presented with progressive back pain, bilate…
View article: The Impact of AI on the Job Market of Machine Learning Engineers
The Impact of AI on the Job Market of Machine Learning Engineers Open
- In the given research paper, the drastic effects of the artificial intelligence (AI) on the employment market of machine learning engineers are explored regarding the changing trends in employment, required skills, and workforce issues. …
View article: Greening rice-fallow areas: integrating pulses and oilseeds for sustainable cropping in eastern India
Greening rice-fallow areas: integrating pulses and oilseeds for sustainable cropping in eastern India Open
Rice-fallow areas, widespread in rainfed rice-growing regions of South Asia, remain uncultivated during the post-rainy (winter) season due to multiple challenges, including inadequate irrigation infrastructure, cultivation of long-duration…
View article: Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate
Prevention of tuberculosis in cynomolgus macaques by an attenuated Mycobacterium tuberculosis vaccine candidate Open
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacille Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (M…
View article: A Discrete Choice Experiment-Based Framework for Designing Farmer-Centric Voluntary Carbon Credit Incentives: A Policy Perspective
A Discrete Choice Experiment-Based Framework for Designing Farmer-Centric Voluntary Carbon Credit Incentives: A Policy Perspective Open
View article: Functional Outcome of Metacarpal Fractures Managed by Internal Fixation with Miniplate and Screws: A Cross-Sectional Study
Functional Outcome of Metacarpal Fractures Managed by Internal Fixation with Miniplate and Screws: A Cross-Sectional Study Open
Background: Metacarpal fractures account for up to 40% of all hand fractures. This is commonly encountered among the general population, labour workers, and sportsmen. The appropriateness of the intervention in such cases becomes very impo…
View article: Immunogenicity and safety of an <i>Entamoeba histolytica</i> adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques
Immunogenicity and safety of an <i>Entamoeba histolytica</i> adjuvanted protein vaccine candidate (LecA+GLA-3M-052 liposomes) in rhesus macaques Open
Entamoeba histolytica, the causative agent of amebiasis, is one of the top three parasitic causes of mortality worldwide. However, no vaccine exists against amebiasis. Using a lead candidate vaccine containing the LecA fragment of G…
View article: Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance
Proteomic analysis of lung responses to SARS-CoV-2 infection in aged non-human primates: clinical and research relevance Open
View article: Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection
Indoleamine-2,3-dioxygenase inhibition improves immunity and is safe for concurrent use with cART during Mtb/SIV coinfection Open
Chronic immune activation promotes tuberculosis (TB) reactivation in the macaque Mycobacterium tuberculosis (M. tuberculosis)/SIV coinfection model. Initiating combinatorial antiretroviral therapy (cART) early lowers the risk of TB reactiv…
View article: Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity
Prevention of TB in nonhuman primates by a stress-response deficient mutant of Mycobacterium tuberculosis via induction of classical T cell immunity Open
The need for novel vaccination strategies to control tuberculosis (TB) is underscored by the limited and variable efficacy of the currently licensed vaccine, Bacillar Calmette-Guerin (BCG). SigH is critical for Mycobacterium tuberculosis (…
View article: Long-Term Spatiotemporal Investigation of Various Rainfall Intensities over Central India Using EO Datasets
Long-Term Spatiotemporal Investigation of Various Rainfall Intensities over Central India Using EO Datasets Open
This study involved an investigation of the long-term seasonal rainfall patterns in central India at the district level during the period from 1991 to 2020, including various aspects such as the spatiotemporal seasonal trend of rainfall pa…
View article: Bioinformatics analysis reveals PIH1D1 as an important prognostic marker in breast cancer
Bioinformatics analysis reveals PIH1D1 as an important prognostic marker in breast cancer Open
R2TP (Rvb1, Rvb2, Tah1, and Pih1) complex was initially discovered as a Heat shock protein 90 associated multimeric protein complex in yeast and is highly conserved in mammals. In Human R2TP complex is known by different names including RU…
View article: PIH1D1 as a potential biomarkers candidate for diagnostic approach in Breast Cancer
PIH1D1 as a potential biomarkers candidate for diagnostic approach in Breast Cancer Open
The R2TP complex is a co-chaperone conserved from Yeast to mammals and comprises of RUVBL1, RUVBL2, PIH1D1 and RPAP3 in Human is known to be a specialized Co-chaperone of Hsp-90 protein. A number of multi-subunit complexes, such as RNA pol…
View article: Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy
Immune Responses in Lung Granulomas during Mtb/HIV Co-Infection: Implications for Pathogenesis and Therapy Open
HIV and TB are the cause of significant worldwide mortality and pose a grave danger to the global public health. TB is the leading cause of death in HIV-infected persons, with one in four deaths attributable to TB. While the majority of he…
View article: Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control
Antigen-specific B cells direct T follicular-like helper cells into lymphoid follicles to mediate Mycobacterium tuberculosis control Open
View article: Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy
Inhibition of indoleamine dioxygenase leads to better control of tuberculosis adjunctive to chemotherapy Open
The expression of indoleamine 2,3-dioxygenase (IDO), a robust immunosuppressant, is significantly induced in macaque tuberculosis (TB) granulomas, where it is expressed on IFN-responsive macrophages and myeloid-derived suppressor cells. ID…
View article: Assessing performance of horticultural farmers producer companies: Comparative case study
Assessing performance of horticultural farmers producer companies: Comparative case study Open
Every year the horticultural sector of India faces huge quantity of food wastage due to lack of processing, value addition and post-harvest handling. Farmers Producer Company (FPC) can mitigate the loss through ensuring better value chain …
View article: Structural, functional and evolutionary analysis of wheat WRKY45 protein: A combined bioinformatics and MD simulation approach
Structural, functional and evolutionary analysis of wheat WRKY45 protein: A combined bioinformatics and MD simulation approach Open
Bread wheat (Triticum aestivum L.) is the world’s second-most important cereal crop, as well as India’s. It is an allohexaploid composed of three homeologous sub-genomes (AA, BB, and DD), which is a constraint in determining the complete g…
View article: System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection
System-wide identification of myeloid markers of TB disease and HIV-induced reactivation in the macaque model of Mtb infection and Mtb/SIV co-infection Open
Mycobacterium tuberculosis ( Mtb ) has developed specialized mechanisms to parasitize its host cell, the macrophage. These mechanisms allow it to overcome killing by oxidative burst and persist in the wake of an inflammatory response. Mtb …
View article: Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples
Diagnosis of paediatric tuberculosis by optically detecting two virulence factors on extracellular vesicles in blood samples Open
Sensitive and specific blood-based assays for the detection of pulmonary and extrapulmonary tuberculosis would reduce mortality associated with missed diagnoses, particularly in children. Here we report a nanoparticle-enhanced immunoassay …
View article: ESTIMATION OF PARAMETERS AND STABILITY ANALYSIS OF CORONAVIRUS PANDEMIC
ESTIMATION OF PARAMETERS AND STABILITY ANALYSIS OF CORONAVIRUS PANDEMIC Open
View article: Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs
Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs Open
A once-weekly oral dose of isoniazid and rifapentine for 3 months (3HP) is recommended by the CDC for treatment of latent tuberculosis infection (LTBI). The aim of this study is to assess 3HP-mediated clearance of M. tuberculosis bacteria …
View article: CONTRIBUTION OF THE ECONOMIC SECTOR TO INDONESIA'S ECONOMIC GROWTH IN 2020-2022
CONTRIBUTION OF THE ECONOMIC SECTOR TO INDONESIA'S ECONOMIC GROWTH IN 2020-2022 Open
This research on the contribution of the economic sector toIndonesia's economic growth aims to find out how much the contributionof the economic sector through its various activities has an influence onIndonesia's economic growth which is …
View article: Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques
Peripheral Blood Markers Correlate with the Progression of Active Tuberculosis Relative to Latent Control of Mycobacterium tuberculosis Infection in Macaques Open
Despite a century of research into tuberculosis (TB), there is a dearth of reproducible, easily quantifiable, biomarkers that can predict disease onset and differentiate between host disease states. Due to the challenges associated with hu…