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View article: Isolation and Identification of Bacterial Pathogens from Blood Cultures in a Tertiary Care Hospital and Their Clinical Correlation
Isolation and Identification of Bacterial Pathogens from Blood Cultures in a Tertiary Care Hospital and Their Clinical Correlation Open
Objective: This study aimed to isolate and identify bacterial pathogens from blood cultures of patients with suspected bloodstream infections (BSIs) in a tertiary care hospital, analyze their antimicrobial susceptibility patterns, and esta…
View article: CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation
CEP41, a ciliopathy-linked centrosomal protein, regulates microtubule assembly and cell proliferation Open
Centrosomal proteins play pivotal roles in orchestrating microtubule dynamics, and their dysregulation leads to disorders, including cancer and ciliopathies. Understanding the multifaceted roles of centrosomal proteins is vital to comprehe…
View article: CCDC 2035519: Experimental Crystal Structure Determination
CCDC 2035519: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest Open
Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
View article: Data from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
Data from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest Open
Estramustine (EM) alone or in combination with other anticancer agents is clinically used for the treatment of hormone refractory prostate cancer. Furthermore, EM has been shown to potently inhibit the proliferation of different types of c…
View article: Data from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
Data from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest Open
Estramustine (EM) alone or in combination with other anticancer agents is clinically used for the treatment of hormone refractory prostate cancer. Furthermore, EM has been shown to potently inhibit the proliferation of different types of c…
View article: Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest Open
Supplementary Figures 1-5 from Kinetic Stabilization of Microtubule Dynamics by Estramustine Is Associated with Tubulin Acetylation, Spindle Abnormalities, and Mitotic Arrest
View article: Models versus pathogens: how conserved is the FtsZ in bacteria?
Models versus pathogens: how conserved is the FtsZ in bacteria? Open
Combating anti-microbial resistance by developing alternative strategies is the need of the hour. Cell division, particularly FtsZ, is being extensively studied for its potential as an alternative target for anti-bacterial therapy. Bacillu…
View article: Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage
Copper-Plumbagin Complex Produces Potent Anticancer Effects by Depolymerizing Microtubules and Inducing Reactive Oxygen Species and DNA Damage Open
Here, we have synthesized a copper complex of plumbagin (Cu-PLN) and investigated its antiproliferative activities in different cancer cells. The crystal structure of Cu-PLN showed that the complex was square planar with a binding stoichio…
View article: Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor
Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor Open
Multi-drug resistance is increasing in the pathogenic bacterium S. pneumoniae, which is mainly responsible for meningitis and community-acquired pneumonia (CAP), highlighting the need for new anti-pneumococcal agents. We have identified a …
View article: Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in <i>Streptococcus pneumoniae</i> and displays anti-pneumococcal activity
Vitamin K3 inhibits FtsZ assembly, disrupts the Z-ring in <i>Streptococcus pneumoniae</i> and displays anti-pneumococcal activity Open
The respiratory pathogen, Streptococcus pneumoniae has acquired multiple-drug resistance over the years. An attractive strategy to combat pneumococcal infection is to target cell division to inhibit the proliferation of S. pneumoniae. This…
View article: Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells
Hyperthermia induced disruption of mechanical balance leads to G1 arrest and senescence in cells Open
Human body temperature limits below 40°C during heat stroke or fever. The implications of prolonged exposure to the physiologically relevant temperature (40°C) on cellular mechanobiology is poorly understood. Here, we have examined the eff…
View article: Evidence of conformational switch in <scp><i>Streptococcus pneumoniae</i> FtsZ</scp> during polymerization
Evidence of conformational switch in <span><i>Streptococcus pneumoniae</i> FtsZ</span> during polymerization Open
FtsZ, the master coordinator of bacterial cell division, assembles into filaments in the presence of nucleotide. FtsZ from Streptococcus pneumoniae bears two tryptophan residues (W294 and W378) in its amino acid sequence. The tryptophan fl…
View article: Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents
Methyl-β-cyclodextrin, an actin depolymerizer augments the antiproliferative potential of microtubule-targeting agents Open
Methyl-β-cyclodextrin (MCD), an established pharmacological excipient, depolymerizes the actin cytoskeleton. In this work, we investigated the effect of MCD-mediated actin depolymerization on various cellular phenotypes including traction …
View article: Regulation of <i>Streptococcus pneumoniae</i> FtsZ assembly by divalent cations: paradoxical effects of Ca<sup>2+</sup> on the nucleation and bundling of FtsZ polymers
Regulation of <i>Streptococcus pneumoniae</i> FtsZ assembly by divalent cations: paradoxical effects of Ca<sup>2+</sup> on the nucleation and bundling of FtsZ polymers Open
The assembly and disassembly of the FtsZ ring drives the division of bacteria cells, including Streptococcus pneumoniae , which causes pneumonia and meningitis. In contrast to FtsZ from other bacterial species, Streptococcus pneumoniae ( S…
View article: Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents
Combretastatin-Inspired Heterocycles as Antitubulin Anticancer Agents Open
Combretastatin (CA-4) and its analogues are undergoing several clinical trials for treating different types of tumors. In this work, the antiproliferative activity of a series of 2-aminoimidazole-carbonyl analogs of clinically relevant com…
View article: A centrosomal protein STARD9 promotes microtubule stability and regulates spindle microtubule dynamics
A centrosomal protein STARD9 promotes microtubule stability and regulates spindle microtubule dynamics Open
Centrosomal proteins play important roles in the spindle assembly and the segregation of chromosomes in the eukaryotic cells. STARD9, a recently identified centrosomal protein, was reported to influence the spindle pole assembly. However, …
View article: PO-027 Methyl-β-cyclodextrin intensifies the effect of microtubule-targeting agents by increasing their intracellular drug accumulation
PO-027 Methyl-β-cyclodextrin intensifies the effect of microtubule-targeting agents by increasing their intracellular drug accumulation Open
Introduction Microtubule-targeting agents (MTA’s) are conventionally used the first-line chemotherapeutic drug for its treatment however, it is accompanied by several limitations like drug resistance and tumour reoccurrence leading to its…
View article: Regulation of microtubule stability by centrosomal proteins
Regulation of microtubule stability by centrosomal proteins Open
The centrosome executes diverse functions including the nucleation and organization of microtubules. A subset of centrosomal proteins is found to be involved in regulating the nucleation, stability, and dynamics of microtubules. Literature…
View article: Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes
Interaction of microtubule depolymerizing agent indanocine with different human αβ tubulin isotypes Open
Tubulin isotypes are known to regulate the stability and dynamics of microtubules, and are also involved in the development of resistance against microtubule-targeted cancer drugs. Indanocine, a potent microtubule depolymerizing agent, is …