Dharmesh Patel
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View article: Evaluation of Cepheid Xpert Xpress CoV-2/Flu/RSV plus for nasal and nasopharyngeal specimens tested in CLIA-accredited and CLIA-waived settings
Evaluation of Cepheid Xpert Xpress CoV-2/Flu/RSV plus for nasal and nasopharyngeal specimens tested in CLIA-accredited and CLIA-waived settings Open
This study demonstrates that Xpert Xpress CoV-2/Flu/RSV plus provides rapid and accurate results from NPS and NS specimens in CA and CW testing facilities regardless of staff experience with molecular testing.
View article: Prospective, multi-site evaluation of the Cepheid Xpert Xpress CoV-2 <i>plus</i> test on nasal and nasopharyngeal swabs
Prospective, multi-site evaluation of the Cepheid Xpert Xpress CoV-2 <i>plus</i> test on nasal and nasopharyngeal swabs Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues its largely aseasonal spread with millions of cases per year. Highly sensitive, point-of-care testing is critical for rapid detection of coronavirus disease 2019 (COVID…
View article: Exploring the Impact of Vitamin D Supplementation on Metabolic Syndrome Variables in Postmenopausal Women: A Comprehensive Review
Exploring the Impact of Vitamin D Supplementation on Metabolic Syndrome Variables in Postmenopausal Women: A Comprehensive Review Open
View article: Computed tomography findings of COVID-19-associated pulmonary mucormycosis: Data from a multicenter retrospective study (Mucovi2), India
Computed tomography findings of COVID-19-associated pulmonary mucormycosis: Data from a multicenter retrospective study (Mucovi2), India Open
Dear Editor, A large number of mucormycosis cases were reported in India following the second wave of COVID-19.[1] However, data on the imaging appearance of COVID-19-associated pulmonary mucormycosis (CAPM) are limited.[2] A few published…
View article: Pleural effusion guidelines from ICS and NCCP Section 1: Basic principles, laboratory tests and pleural procedures
Pleural effusion guidelines from ICS and NCCP Section 1: Basic principles, laboratory tests and pleural procedures Open
Pleural effusion is a common problem in our country, and most of these patients need invasive tests as they can’t be evaluated by blood tests alone. The simplest of them is diagnostic pleural aspiration, and diagnostic techniques such as m…
View article: Health information technology tools to accelerate gastrointestinal evaluation in patients with iron deficiency anaemia: a cluster randomised controlled trial
Health information technology tools to accelerate gastrointestinal evaluation in patients with iron deficiency anaemia: a cluster randomised controlled trial Open
Objective System-level safety measures do not exist to ensure that patients with iron deficiency anaemia (IDA) undergo proper diagnostic evaluations. We sought to determine if a set of EHR (electronic health record) tools and an expedited …
View article: Factors Associated with Pulmonary and Extrapulmonary Tuberculosis: A Case-case Study
Factors Associated with Pulmonary and Extrapulmonary Tuberculosis: A Case-case Study Open
INTRODUCTION: Despite low TB incidence in Castellon and La Plana-Vila-Real health departments (2013-2016), elimination remains challenging, especially in marginalized populations. However, TB elimination is challenging. It is frequent to f…
View article: Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis/mycoses
Revised ISHAM-ABPA working group clinical practice guidelines for diagnosing, classifying and treating allergic bronchopulmonary aspergillosis/mycoses Open
Background The International Society for Human and Animal Mycology (ISHAM) working group proposed recommendations for managing allergic bronchopulmonary aspergillosis (ABPA) a decade ago. There is a need to update these recommendations due…
View article: A Study of Online Teaching Strategies During Covid-19 of Secondary School Teachers
A Study of Online Teaching Strategies During Covid-19 of Secondary School Teachers Open
During the advent of COVID-19, it became inevitable to switch from traditional face-to-face teaching to online teaching mode. Switching to the online teaching process was the only option left for uninterrupted learning. One of the ways to …
View article: Right Ventricle Thrombus and COVID-19 Infection: An Uncommon Report of Three Cases
Right Ventricle Thrombus and COVID-19 Infection: An Uncommon Report of Three Cases Open
Case seriesthrombolyzed with 100 mg injection actilyse [recombinant tissue plasminogen activator (rt-PA)] over 2 hours.2D-echo was repeated again (Video 2) and showed reduction in the size of thrombus.After 10 days, oxygen requirement was …
View article: Guidelines for endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA): Joint Indian Chest Society (ICS)/Indian Association for Bronchology (IAB) recommendations
Guidelines for endobronchial ultrasound-transbronchial needle aspiration (EBUS-TBNA): Joint Indian Chest Society (ICS)/Indian Association for Bronchology (IAB) recommendations Open
Over the past decade, endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) has become an indispensable tool in the diagnostic armamentarium of the pulmonologist. As the expertise with EBUS-TBNA has evolved and sever…
View article: Instability of the distal tibiofibular syndesmosis
Instability of the distal tibiofibular syndesmosis Open
The distal tibiofibular syndesmosis (DTFS) is more frequently injured than previously thought. Early diagnosis and appropriate treatment is essential to avoid long term complications like chronic instability, early osteoarthritis and resid…
View article: Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Material and Methods
View article: Data from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Data from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Insulin-like growth factor receptor 1 (IGF-1R)–targeting therapies are currently at an important crossroad given the low clinical response rates seen in unselected patients. Predictive biomarkers for patient selection are critical for impr…
View article: Supplementary Figures S1-S5 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Figures S1-S5 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Supplementary Figures S1-S5. Supplementary Figure S1. Similarity of CNV profiles are seen from both CRC cell lines and CRC primary tumor samples with highlight on chromosome 13 copy number gain. Supplementary Figure S2: The RNA expression …
View article: Data from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Data from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Insulin-like growth factor receptor 1 (IGF-1R)–targeting therapies are currently at an important crossroad given the low clinical response rates seen in unselected patients. Predictive biomarkers for patient selection are critical for impr…
View article: Supplementary Tables S1-S4 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Tables S1-S4 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Supplementary Tables S1-S4. Supplementary Table S1: Association of gene mutations, IRS2 copy number gain, and gene expression level with in vitro sensitivity to BMS-754807 in 60 CRC cell lines. Supplementary Table S2: The relationship betw…
View article: Supplementary Tables S1-S4 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Tables S1-S4 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Supplementary Tables S1-S4. Supplementary Table S1: Association of gene mutations, IRS2 copy number gain, and gene expression level with in vitro sensitivity to BMS-754807 in 60 CRC cell lines. Supplementary Table S2: The relationship betw…
View article: Supplementary Figures S1-S5 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Figures S1-S5 from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Supplementary Figures S1-S5. Supplementary Figure S1. Similarity of CNV profiles are seen from both CRC cell lines and CRC primary tumor samples with highlight on chromosome 13 copy number gain. Supplementary Figure S2: The RNA expression …
View article: Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines
Supplementary Material and Methods from <i>IRS2</i> Copy Number Gain, <i>KRAS</i> and <i>BRAF</i> Mutation Status as Predictive Biomarkers for Response to the IGF-1R/IR Inhibitor BMS-754807 in Colorectal Cancer Cell Lines Open
Material and Methods
View article: Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India
Multicenter Case–Control Study of COVID-19–Associated Mucormycosis Outbreak, India Open
We performed a case–control study across 25 hospitals in India for the period of January–June 2021 to evaluate the reasons for an COVID-19–associated mucormycosis (CAM) outbreak. We investigated whether COVID-19 treatment practices (glucoc…
View article: Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study
Clinical features and management of individuals admitted to hospital with monkeypox and associated complications across the UK: a retrospective cohort study Open
View article: Consensus Statement for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis in Resource Constrained Settings
Consensus Statement for the Diagnosis and Treatment of Idiopathic Pulmonary Fibrosis in Resource Constrained Settings Open
Background.Idiopathic pulmonary fibrosis (IPF) is a specific type of chronic fibrosing interstitial lung disease (ILD) that is progressive in course.Although evidence-based guidelines for IPF are available, these are difficult to interpret…
View article: Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection
Vaccination saves lives: a real-time study of patients with chronic diseases and severe COVID-19 infection Open
Objectives This study aims to describe the demographic and clinical profile and ascertain the determinants of outcome among hospitalized coronavirus disease 2019 (COVID-19) adult patients enrolled in the National Clinical Registry for COVI…
View article: Indwelling pleural catheter for malignant pleural effusion – Are we ready?
Indwelling pleural catheter for malignant pleural effusion – Are we ready? Open
“We cannot change the outcome but we can affect the journey” – Ann Richardson Malignant pleural effusion (MPE) is a common and disabling complication of cancer and is associated with significant morbidity and mortality. Life expectancy in …
View article: Experimental testing of fracture fixation plates: A review
Experimental testing of fracture fixation plates: A review Open
Metal and its alloys have been predominantly used in fracture fixation for centuries, but new materials such as composites and polymers have begun to see clinical use for fracture fixation during the past couple of decades. Along with the …
View article: Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India
Definition, diagnosis, and management of COVID-19-associated pulmonary mucormycosis: Delphi consensus statement from the Fungal Infection Study Forum and Academy of Pulmonary Sciences, India Open
View article: Identification of a Novel Unbalanced t(4;8) (q12;q24) in Paediatric Acute Myeloid Leukemia M2 with AML-ETO Negative Patient by Fluorescence in Situ Hybridization Technique
Identification of a Novel Unbalanced t(4;8) (q12;q24) in Paediatric Acute Myeloid Leukemia M2 with AML-ETO Negative Patient by Fluorescence in Situ Hybridization Technique Open
Identification of chromosomal abnormalities in patients with Acute Myeloid Leukemia (AML) has contributed substantially to our current understanding of the molecular pathogenesis underlying leukemogenesis, and risk-stratification. Based on…
View article: Dual mobility cups hip arthroplasty as a treatment for displaced fracture of the femoral neck in the elderly patients: A prospective, systematic study with specific focus on postoperative dislocation using posterior approach.
Dual mobility cups hip arthroplasty as a treatment for displaced fracture of the femoral neck in the elderly patients: A prospective, systematic study with specific focus on postoperative dislocation using posterior approach. Open
Introduction: Displaced fractures of the femoral neck in the elderly are best treated with arthroplasty. The type of arthroplasty to be used, either hemi- or total hip arthroplasty, remains controversial as total hip replacements potential…
View article: Table of Contents
Table of Contents Open