Chen Wang
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View article: Multimorbidity profiles in patient population from Central China: a study based on electronic health records
Multimorbidity profiles in patient population from Central China: a study based on electronic health records Open
Comprehensive, life-course multimorbidity data derived from linked outpatient and inpatient electronic health records (EHRs) remain scarce globally. We analyzed integrated EHRs (2016-2023) from approximately 3.2 million individuals in Yich…
View article: Multimorbidity Profiles in Patient Population from Central China: A Study Based on Electronic Health Records
Multimorbidity Profiles in Patient Population from Central China: A Study Based on Electronic Health Records Open
Comprehensive, life-course multimorbidity data derived from linked outpatient and inpatient electronic health records (EHRs) remain scarce globally. We analyzed integrated EHRs (2016-2023) from approximately 3.2 million individuals in Yich…
View article: The effect of preoperative psychological state on postoperative outcomes of anterior cervical approach in cervical spondylotic myelopathy: a retrospective case‒control study
The effect of preoperative psychological state on postoperative outcomes of anterior cervical approach in cervical spondylotic myelopathy: a retrospective case‒control study Open
Objective To explore the impact of the preoperative psychological state on postoperative clinical outcomes in patients with cervical spondylotic myelopathy(CSM) treated surgically by the anterior cervical approach. Methods A retrospective …
View article: Utility-Learning Tension in Self-Modifying Agents
Utility-Learning Tension in Self-Modifying Agents Open
As systems trend toward superintelligence, a natural modeling premise is that agents can self-improve along every facet of their own design. We formalize this with a five-axis decomposition and a decision layer, separating incentives from …
View article: Neoadjuvant chemotherapy with FOLFOXIRI for high-risk relapsed locally advanced colon cancer: a single-arm phase II trial
Neoadjuvant chemotherapy with FOLFOXIRI for high-risk relapsed locally advanced colon cancer: a single-arm phase II trial Open
For patients with hr-LACC, NAC with FOLFOXIRI regimen has preferable safety and deliverability. Longer follow-up and larger clinical studies are needed to validate its efficacy superiority.
View article: MI9: An Integrated Runtime Governance Framework for Agentic AI
MI9: An Integrated Runtime Governance Framework for Agentic AI Open
Agentic AI systems capable of reasoning, planning, and executing actions present fundamentally distinct governance challenges compared to traditional AI models. Unlike conventional AI, these systems exhibit emergent and unexpected behavior…
View article: Doxorubicin delivery by pYEEIE peptide-functionalized rhodiola rosea-derived exosome-like nanovesicles for targeted melanoma therapy
Doxorubicin delivery by pYEEIE peptide-functionalized rhodiola rosea-derived exosome-like nanovesicles for targeted melanoma therapy Open
Introduction Melanoma is the most common cause of skin cancer-related deaths due to its aggressive nature. Plant-derived exosome-like nanovesicles (PELNs) are promising natural nanoparticles for therapeutic applications owing to their bioc…
View article: Depression impact on PTSD in Cancer patients through serial mediation of hope and perceived social support
Depression impact on PTSD in Cancer patients through serial mediation of hope and perceived social support Open
View article: Performance of Bleeding Risk Scores for Major Bleeding in Anticoagulated Patients with Pulmonary Embolism: Insights from the CURES Registry-2
Performance of Bleeding Risk Scores for Major Bleeding in Anticoagulated Patients with Pulmonary Embolism: Insights from the CURES Registry-2 Open
Most bleeding risk scores for pulmonary embolism (PE) were developed in patients receiving traditional anticoagulants. Evidence in East Asian populations and its applicability to direct oral anticoagulants (DOACs) remain limited. This post…
View article: Factors associated with and kinetics of anti–IFN-α autoantibodies in RAG1/2 deficiency
Factors associated with and kinetics of anti–IFN-α autoantibodies in RAG1/2 deficiency Open
Anti-IFN-α autoantibodies reflect immune dysregulation in partial RAG deficiency. Their production is likely aggravated by environmental factors, especially frequent viral infections. Further studies are needed to define their pathogenic r…
View article: Global, regional, and national burden of vascular intestinal disorders, 1990–2021 and predictions to 2035: A systemic analysis for the Global Burden of Disease Study
Global, regional, and national burden of vascular intestinal disorders, 1990–2021 and predictions to 2035: A systemic analysis for the Global Burden of Disease Study Open
Objective This study aims to summarize and evaluate the temporal trends of the disease burden of vascular intestinal disorders (VID) in China and globally from 1990 to 2021, and to predict the disease burden to 2035. Methods We conducted a…
View article: Prevalence of myeloid gene alterations in paediatric cutaneous and systemic mastocytosis
Prevalence of myeloid gene alterations in paediatric cutaneous and systemic mastocytosis Open
Summary Paediatric mastocytosis is a heterogeneous disorder with different clinical subtypes and an often indolent disease course. The molecular landscape of genetic mutations, beyond KIT D816V, remains under exploration. We thus investiga…
View article: Burden of chronic respiratory diseases and their attributable risk factors in 204 countries and territories, 1990–2021: Results from the global burden of disease study 2021
Burden of chronic respiratory diseases and their attributable risk factors in 204 countries and territories, 1990–2021: Results from the global burden of disease study 2021 Open
View article: Functionalized turmeric nanovesicles for precision delivery of doxorubicin in colorectal carcinoma treatment
Functionalized turmeric nanovesicles for precision delivery of doxorubicin in colorectal carcinoma treatment Open
Nanoscale vesicles have emerged as promising biocompatible vehicles for precision drug delivery, owing to their inherent therapeutic properties and versatile structural configurations. This study introduces an innovative biomanufacturing s…
View article: Inhaled PAMAM-based nano-formulation prolonged lung retention for alleviating pulmonary inflammation of COPD
Inhaled PAMAM-based nano-formulation prolonged lung retention for alleviating pulmonary inflammation of COPD Open
View article: Therapeutic Use of Recombinant Interferon-Gamma in Patients with Refractory Disseminated Coccidioidomycosis
Therapeutic Use of Recombinant Interferon-Gamma in Patients with Refractory Disseminated Coccidioidomycosis Open
Introduction Disseminated coccidioidomycosis (DCM) is a serious illness with significant morbidity and mortality, especially in patients with impaired host defense mechanisms in interferon-gamma (IFN-gamma)/interleukin-12 and STAT3 axes. W…
View article: DOCK8 Deficiency: Extended Clinical Phenotypes and the Impact of Somatic Reversions
DOCK8 Deficiency: Extended Clinical Phenotypes and the Impact of Somatic Reversions Open
Introduction DOCK8 deficiency is a rare combined immunodeficiency characterized by atopy, recurrent oto-sinopulmonary infections, viral skin infections, and malignancy. Mortality is approximately 50% by age 20 without curative hematopoieti…
View article: Effects of glucocorticoid administration routes on patients with acute exacerbations of chronic obstructive pulmonary disease in China: A propensity score-matched longitudinal analysis
Effects of glucocorticoid administration routes on patients with acute exacerbations of chronic obstructive pulmonary disease in China: A propensity score-matched longitudinal analysis Open
Background: Glucocorticoids are widely used for managing acute exacerbations of chronic obstructive pulmonary disease (AECOPD); however, limited studies have described the comparative effectiveness of inhaled corticosteroids (ICS), systemi…
View article: Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages
Severe Acute Pancreatitis Complicated by Multiple Intra-Abdominal Hemorrhages Open
Introduction: Intra-abdominal hemorrhage is a rare yet life-threatening complication of acute pancreatitis (AP), with a higher prevalence in cases of severe acute pancreatitis (SAP). This condition is primarily caused by vessel wall erosio…
View article: Antimicrobial peptide DiPGLa-H exhibits the most outstanding anti-infective activity among the PGLa variants based on a systematic comparison
Antimicrobial peptide DiPGLa-H exhibits the most outstanding anti-infective activity among the PGLa variants based on a systematic comparison Open
The escalating threat of antibiotic-resistant bacteria has heightened global interest in antimicrobial peptides as promising candidates due to their potent broad-spectrum activity and low likelihood of resistance development. Despite this …
View article: Choledochoscope-Guided Necrosectomy for Retroperitoneal and Posterior Rectal Post-Pancreatitis Necrosis
Choledochoscope-Guided Necrosectomy for Retroperitoneal and Posterior Rectal Post-Pancreatitis Necrosis Open
BACKGROUND Severe acute pancreatitis is a severe acute abdominal disease. Signs and symptoms classically vary from abdominal pain to fever, vomiting, and abdominal distension. Severe complications, such as infected pancreatic necrosis and …
View article: A15 THERAPEUTIC POTENTIAL OF THE GLYCOCAGE TARGETED DELIVERY SYSTEM FOR IMPROVING INFLAMMATORY BOWEL DISEASE TREATMENT
A15 THERAPEUTIC POTENTIAL OF THE GLYCOCAGE TARGETED DELIVERY SYSTEM FOR IMPROVING INFLAMMATORY BOWEL DISEASE TREATMENT Open
Background Inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), is marked by chronic inflammation along the gastrointestinal tract (GIT). IBD cases are rising globally, with Canada having one of …
View article: Infections in Inborn Errors of STATs
Infections in Inborn Errors of STATs Open
The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway is highly conserved and essential for numerous biological functions triggered by extracellular signals, including cell proliferation, metabolism, immune…
View article: Accumulated subcutaneous fat in abdomen is associated with long COVID-19 symptoms among non-hospitalized patients: a prospective observational study
Accumulated subcutaneous fat in abdomen is associated with long COVID-19 symptoms among non-hospitalized patients: a prospective observational study Open
Introduction Long COVID-19 symptoms may have a variety of potential overlapping causes. In this study, we aimed to investigate the potential correlation between abdominal adipose tissue and long COVID-19 symptoms in non-hospitalized patien…
View article: Updated consensus statement for pulmonary rehabilitation of patients with coronavirus disease 2019 (2023)
Updated consensus statement for pulmonary rehabilitation of patients with coronavirus disease 2019 (2023) Open
View article: Outcomes by best response with hypomethylating agent plus venetoclax in adults with previously untreated acute myeloid leukemia
Outcomes by best response with hypomethylating agent plus venetoclax in adults with previously untreated acute myeloid leukemia Open
View article: Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited
Conventional and genetic associations of BMI with major vascular and non-vascular disease incidence and mortality in a relatively lean Chinese population: U-shaped relationship revisited Open
Background Higher body mass index (BMI) is associated with higher incidence of cardiovascular and some non-cardiovascular diseases (CVDs/non-CVDs). However, uncertainty remains about its associations with mortality, particularly at lower B…
View article: Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives
Synthesis, Anticancer Activity, and Molecular Docking of New 1,2,3-Triazole Linked Tetrahydrocurcumin Derivatives Open
Cancer is one of the deadliest diseases to humanity. There is significant progress in treating this disease, but developing some drugs that can fight this disease remains a challenge in the field of medical research. Thirteen new 1,2,3-tri…
View article: A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension
A new integrative analysis of histopathology and single cell RNA-seq reveals the CCL5 mediated T and NK cell interaction with vascular cells in idiopathic pulmonary arterial hypertension Open
Background Inflammation and dysregulated immunity play vital roles in idiopathic pulmonary arterial hypertension (IPAH), while the mechanisms that initiate and promote these processes are unclear. Methods Transcriptomic data of lung tissue…
View article: Treatment Options for Distal Rectal Cancer in the Era of Organ Preservation
Treatment Options for Distal Rectal Cancer in the Era of Organ Preservation Open