Daidi Fan
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View article: Molecular Engineering of Aggregation‐induced Emission Peroxynitrite Generators for Biofilm Eradication via Bilayer Microneedles
Molecular Engineering of Aggregation‐induced Emission Peroxynitrite Generators for Biofilm Eradication via Bilayer Microneedles Open
Photoactivatable peroxynitrite (ONOO − ), with prolonged half‐life, enhanced diffusion, and precise spatiotemporal control, has emerged as a potent anti‐biofilm and antimicrobial agent. However, conventional ONOO − generators are usually d…
View article: Multi-omics elucidation of recombinant collagen‐mediated modulation of mesenchymal stem cell functions
Multi-omics elucidation of recombinant collagen‐mediated modulation of mesenchymal stem cell functions Open
Recombinant collagen, as a bioactive material, can remodel the functions of mesenchymal stem cells. Specifically, recombinant type I collagen primarily activates the FAK/RHOA/ROCK signaling pathway, while recombinant type III collagen acti…
View article: Advances in Nanotechnology Research in Food Production, Nutrition, and Health
Advances in Nanotechnology Research in Food Production, Nutrition, and Health Open
Nanotechnology, as a burgeoning interdisciplinary field, has a significant application potential in food nutrition and human health due to its distinctive structural characteristics and surface effects. This paper methodically examines the…
View article: Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways
Recombinant Type XVII Collagen Promotes Hair Growth by Activating the Wnt/β-Catenin and SHH/GLI Signaling Pathways Open
(1) Background: As society progresses, increasing numbers of individuals are experiencing hair loss, which can be attributed to factors such as unhealthy diets, insufficient sleep, stress, and hormonal imbalances. Currently available pharm…
View article: Light‐Activated Transient Unilateral Adhesive Recombinant Collagen‐Based Hydrogel for Reversible Fibrosis Induction and Full‐Cycle Management of Pancreatic Fistula
Light‐Activated Transient Unilateral Adhesive Recombinant Collagen‐Based Hydrogel for Reversible Fibrosis Induction and Full‐Cycle Management of Pancreatic Fistula Open
Currently, no effective treatment for pancreatic fistula (PF) exists, which has a mortality rate >40%. Existing protein‐based physical barriers face the challenges of rapid degradation, lack of self‐adhesiveness, and the inability to promo…
View article: A Self-Adhesive Ginsenoside Rk3/Metformin-Loaded Hydrogel Microneedle for Management of Systemic Sclerosis
A Self-Adhesive Ginsenoside Rk3/Metformin-Loaded Hydrogel Microneedle for Management of Systemic Sclerosis Open
Microcirculation damage, dermal thickening, and difficulty in the spatiotemporal coordination of key platelet factor 4 (CXCL4) and transforming growth factor-β (TGF-β) contribute to the lack of effective treatments for systemic sclerosis (…
View article: A Sprayable Hydrogel Based on Biomimetic Polypeptide‐Modified Lipid Nanoparticles for Treating Non‐Compressible Hemorrhaging
A Sprayable Hydrogel Based on Biomimetic Polypeptide‐Modified Lipid Nanoparticles for Treating Non‐Compressible Hemorrhaging Open
Non‐compressible hemorrhaging is the main cause of death in modern warfare. A biomimetic peptide‐modified lipid nanoparticle‐based sprayable hydrogel is developed to mimic and amplify the blood coagulation process for effective hemostasis.…
View article: Recombinant Type XVII Collagen Inhibits EGFR/MAPK/AP-1 and Activates TGF-β/Smad Signaling to Enhance Collagen Secretion and Reduce Photoaging
Recombinant Type XVII Collagen Inhibits EGFR/MAPK/AP-1 and Activates TGF-β/Smad Signaling to Enhance Collagen Secretion and Reduce Photoaging Open
Studies have consistently shown that long-wave ultraviolet A (UVA) radiation triggers skin photoaging, which is evident as reduced elasticity, a loss of firmness, and signs of aging. There is an urgent need to investigate photoaging mechan…
View article: Electrochemical N–N Oxidatively Coupled Dehydrogenation of 3,5-Diamino-1<i>H</i>-1,2,4-triazole for Value-Added Chemicals and Bipolar Hydrogen Production
Electrochemical N–N Oxidatively Coupled Dehydrogenation of 3,5-Diamino-1<i>H</i>-1,2,4-triazole for Value-Added Chemicals and Bipolar Hydrogen Production Open
Electrochemical H2 production from water favors low-voltage molecular oxidation to replace the oxygen evolution reaction as an energy-saving and value-added approach. However, there exists a mismatch between the high demand for H2 and slow…
View article: Qualitative and Quantitative Analysis Method of Recombinant Collagen in Complex Matrix Based on HPLC-MS/MS
Qualitative and Quantitative Analysis Method of Recombinant Collagen in Complex Matrix Based on HPLC-MS/MS Open
The purpose of this study is to achieve the quantitative detection of recombinant type III collagen (rh-COL-III) in dressings with complex matrix. First of all, the marker peptide (GEAGIPGVPGAK) of rhCOL-III was identified with HPLC-MS/MS.…
View article: Glu@Zn‐Ni MOF Constructed Through Ligand Exchange for Bi‐Enzyme Immobilization With Improved Performance in Rare Ginsenoside Production
Glu@Zn‐Ni MOF Constructed Through Ligand Exchange for Bi‐Enzyme Immobilization With Improved Performance in Rare Ginsenoside Production Open
The biological conversion method using immobilized enzymes has become an important means to produce ginsenosides. Among them, the preprepared Zn‐Ni MOF could be used to immobilize glycosyltransferase by specific adsorption for ginsenoside …
View article: Scalable Electro‐Biosynthesis of Ectoine from Greenhouse Gases
Scalable Electro‐Biosynthesis of Ectoine from Greenhouse Gases Open
Converting greenhouse gases into valuable products has become a promising approach for achieving a carbon‐neutral economy and sustainable development. However, the conversion efficiency depends on the energy yield of the substrate. In this…
View article: PLS‐Guided Mutant Recombination to Improve the Stability of Bovine Enterokinases Obtained by Directed Evolution
PLS‐Guided Mutant Recombination to Improve the Stability of Bovine Enterokinases Obtained by Directed Evolution Open
Activity and thermostability are critical yet challenging to improve simultaneously in enzymes. Using directed evolution, we previously identified bovine enterokinase (EK L ) variants with enhanced soluble expression and thermal stability.…
View article: Nanocomposite Hydrogel for Real‐Time Wound Status Monitoring and Comprehensive Treatment
Nanocomposite Hydrogel for Real‐Time Wound Status Monitoring and Comprehensive Treatment Open
Current skin sensors or wound dressings fall short in addressing the complexities and challenges encountered in real‐world scenarios, lacking adequate capability to facilitate wound repair. The advancement of methodologies enabling early d…
View article: Sulforaphane nanoparticles coated with zein‐propylene glycol alginate attenuate <i>N</i> ‐diethylnitrosamine‐induced liver injury in mice
Sulforaphane nanoparticles coated with zein‐propylene glycol alginate attenuate <i>N</i> ‐diethylnitrosamine‐induced liver injury in mice Open
Sulforaphane‐loaded nanoparticles (NP‐SF) were prepared in this study to improve their biological effects. Based on propylene glycol alginate and zein as wall materials and anthocyanin and CaCl 2 as crosslinking agents, the NPs were encaps…
View article: Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions
Light‐Operated Transient Unilateral Adhesive Hydrogel for Comprehensive Prevention of Postoperative Adhesions Open
Dislocation of anti‐adhesion materials, non‐specific tissue adhesion, and the induction of secondary fibrinolysis disorders are the main challenges faced by postoperative anti‐adhesion materials. Herein, a self‐leveling transient unilatera…
View article: Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9–CXCR3 axis
Ginsenoside Rh4 alleviates idiopathic pulmonary fibrosis by enhancing the CXCL9–CXCR3 axis Open
Idiopathic pulmonary fibrosis (IPF), often likened to a “tumor‐like disease,” proves more lethal than several malignancies. Although prior studies have demonstrated the lung‐protective efficacy of ginsenosides, the precise mechanism underl…
View article: Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway
Ginsenoside Rk1 induces autophagy-dependent apoptosis in hepatocellular carcinoma by AMPK/mTOR signaling pathway Open
Hepatocellular carcinoma (HCC) is the third most lethal cancer in the world. Recent studies have shown that suppression of autophagy plays an important role in the development of HCC. Ginsenoside Rk1 is a protopanaxadiol saponin isolated f…
View article: Natural bioactive compounds as potential sources for alleviation and treatment of androgenetic alopecia: A research advance
Natural bioactive compounds as potential sources for alleviation and treatment of androgenetic alopecia: A research advance Open
Alopecia is a common chronic skin disease, which can be categorized as androgenetic alopecia (AGA), scarring line alopecia, genetic alopecia, and chemical alopecia due to the different reasons. Among which AGA caused by metabolism of the a…