Di Lang
YOU?
Author Swipe
View article: Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium
Stem cell-derived heterocellular atrial engineered cardiac tissue with comparisons to native human atrial myocardium Open
We demonstrate an atrial-like engineered cardiac tissue that recapitulates adult human atrial contraction for both kinetics and force production. Furthermore, we include numerous previously unmeasured ultrastructure metrics such as sarcome…
View article: Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist
Subcellular activation of β-adrenergic receptors using a spatially restricted antagonist Open
Gprotein-coupled receptors (GPCRs) regulate several physiological and pathological processes and represent the target of approximately 30% of Food and Drug Administration-approved drugs. GPCR-mediated signaling was thought to occur exclusi…
View article: Modeling Idiopathic Ventricular Fibrillation Using iPSC Cardiomyocytes and Computational Approaches
Modeling Idiopathic Ventricular Fibrillation Using iPSC Cardiomyocytes and Computational Approaches Open
Idiopathic ventricular fibrillation (IVF) is an unrefined diagnosis representing a heterogeneous patient group without a structural or genetic definition. IVF treatment is not mechanistic-based due to the lack of experimental patient-model…
View article: Caveolar Compartmentalization of Pacemaker Signaling is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure
Caveolar Compartmentalization of Pacemaker Signaling is Required for Stable Rhythmicity of Sinus Nodal Cells and is Disrupted in Heart Failure Open
Background Heart rhythm relies on complex interactions between electrogenic membrane proteins and intracellular Ca 2+ signaling in sinoatrial node (SAN) myocytes; however, mechanisms underlying the functional organization of proteins invol…
View article: Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes
Cholecystokinin-A signaling regulates automaticity of pacemaker cardiomyocytes Open
Aims: The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs). The aims of the present study are to c…
View article: Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes
Cholecystokinin-A Signaling Regulates Automaticity of Pacemaker Cardiomyocytes Open
Aims The behavior of pacemaker cardiomyocytes (PCs) in the sinoatrial node (SAN) is modulated by neurohormonal and paracrine factors, many of which signal through G-protein coupled receptors (GPCRs). The aims of the present study are to ca…
View article: A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene
A phenotype-based forward genetic screen identifies Dnajb6 as a sick sinus syndrome gene Open
Previously we showed the generation of a protein trap library made with the gene-break transposon (GBT) in zebrafish ( Danio rerio ) that could be used to facilitate novel functional genome annotation towards understanding molecular underp…
View article: A phenotype-based forward genetic screen identifies <i>Dnajb6</i> as a sick sinus syndrome gene
A phenotype-based forward genetic screen identifies <i>Dnajb6</i> as a sick sinus syndrome gene Open
Sick sinus syndrome (SSS) is a group of heart rhythm disorders caused by malfunction of the sinus node, the heart’s primary pacemaker. Partially owing to its aging-associated phenotypic manifestation and low expressivity, molecular mechani…
View article: Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium
Region-specific distribution of transversal-axial tubule system organization underlies heterogeneity of calcium dynamics in the right atrium Open
Mouse and human atrial myocardium demonstrate high variability in the organization of the transversal-axial tubule system (TATS), with more organized TATS expressed in the right atrial appendage. TATS distribution governs anatomical hetero…
View article: Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes
Micropattern platform promotes extracellular matrix remodeling by human PSC‐derived cardiac fibroblasts and enhances contractility of co‐cultured cardiomyocytes Open
In native heart tissue, cardiac fibroblasts provide the structural framework of extracellular matrix (ECM) while also influencing the electrical and mechanical properties of cardiomyocytes. Recent advances in the field of stem cell differe…
View article: Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome
Cellular and Molecular Mechanisms of Functional Hierarchy of Pacemaker Clusters in the Sinoatrial Node: New Insights into Sick Sinus Syndrome Open
The sinoatrial node (SAN), the primary pacemaker of the heart, consists of a heterogeneous population of specialized cardiac myocytes that can spontaneously produce action potentials, generating the rhythm of the heart and coordinating hea…
View article: Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology
Human iPSC-engineered cardiac tissue platform faithfully models important cardiac physiology Open
This study seeks to provide an in-depth assessment of contractile performance of human iPSC-derived cardiomyocytes cultured together with fibroblasts in a 3-dimensional-engineered tissue strip and compares performance both over time as the…
View article: Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts
Aligned human cardiac syncytium for in vitro analysis of electrical, structural, and mechanical readouts Open
Human pluripotent stem cell‐derived cardiomyocytes (hPSC‐CMs) have emerged as an exciting new tool for cardiac research and can serve as a preclinical platform for drug development and disease modeling studies. However, these aspirations a…
View article: Genetic Loss of <i>I</i> <sub>K1</sub> Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia
Genetic Loss of <i>I</i> <sub>K1</sub> Causes Adrenergic-Induced Phase 3 Early Afterdepolariz ations and Polymorphic and Bidirectional Ventricular Tachycardia Open
Background: Arrhythmia syndromes associated with KCNJ2 mutations have been described clinically; however, little is known of the underlying arrhythmia mechanism. We create the first patient inspired KCNJ2 transgenic mouse and study effects…
View article: Editorial: Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling
Editorial: Cardiomyocyte Microdomains: An Emerging Concept of Local Regulation and Remodeling Open
EDITORIAL article Front. Physiol., 26 May 2020Sec. Cardiac Electrophysiology Volume 11 - 2020 | https://doi.org/10.3389/fphys.2020.00512
View article: Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis
Caveolae‐Mediated Activation of Mechanosensitive Chloride Channels in Pulmonary Veins Triggers Atrial Arrhythmogenesis Open
Background Atrial fibrillation often occurs in the setting of hypertension and associated atrial dilation with pathologically increased cardiomyocyte stretch. In the setting of atrial dilation, mechanoelectric feedback has been linked to t…
View article: Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation
Epigenetic Priming of Human Pluripotent Stem Cell-Derived Cardiac Progenitor Cells Accelerates Cardiomyocyte Maturation Open
Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) exhibit a fetal phenotype that limits in vitro and therapeutic applications. Strategies to promote cardiomyocyte maturation have focused interventions on differentiated hPSC-CMs…
View article: Long QT syndrome caveolin‐3 mutations differentially modulate K<sub>v</sub>4 and Ca<sub>v</sub>1.2 channels to contribute to action potential prolongation
Long QT syndrome caveolin‐3 mutations differentially modulate K<sub>v</sub>4 and Ca<sub>v</sub>1.2 channels to contribute to action potential prolongation Open
Key points Mutations in the caveolae scaffolding protein, caveolin‐3 (Cav3), have been linked to the long QT type 9 inherited arrhythmia syndrome (LQT9) and the cause of underlying action potential duration prolongation is incompletely und…
View article: Functional Microdomains in Heart’s Pacemaker: A Step Beyond Classical Electrophysiology and Remodeling
Functional Microdomains in Heart’s Pacemaker: A Step Beyond Classical Electrophysiology and Remodeling Open
Spontaneous beating of the sinoatrial node (SAN), the primary pacemaker of the heart, is initiated, sustained, and regulated by a complex system that integrates ion channels and transporters on the cell membrane surface (often referred to …