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View article: ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain‐not otherwise specified in children aged 4–18 years
ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain‐not otherwise specified in children aged 4–18 years Open
Objectives Abdominal pain related disorders of gut–brain interaction (AP‐DGBIs) such as irritable bowel syndrome (IBS) and functional abdominal pain‐not otherwise specified (FAP) are common conditions in children, significantly impacting q…
View article: Expanding horizons in the presentation, diagnosis, and management of congenital sucrase-isomaltase deficiency in children
Expanding horizons in the presentation, diagnosis, and management of congenital sucrase-isomaltase deficiency in children Open
Congenital sucrase-isomaltase deficiency (CSID) is a disorder of carbohydrate metabolism with a broad clinical presentation. There is growing literature to support the presence of genetic variants of CSID that may mimic symptoms of irritab…
View article: Effect of glycerin on colonic motility in children
Effect of glycerin on colonic motility in children Open
Objective Colonic manometry (CM) involves measurement of colonic neuromuscular activity and administration of a stimulant laxative, most commonly bisacodyl, which is part of the study protocol. Glycerin is another laxative used in the trea…
View article: Significance of retrograde flow with antegrade continence enemas in children with fecal incontinence and constipation
Significance of retrograde flow with antegrade continence enemas in children with fecal incontinence and constipation Open
View article: Faecal impaction in children aged 0–18 years: a systematic review and metanarrative analysis of definitions used
Faecal impaction in children aged 0–18 years: a systematic review and metanarrative analysis of definitions used Open
Background Faecal impaction is the result of functional constipation in the majority of cases. Surprisingly, a uniform definition for the term faecal impaction is lacking, leading to heterogeneity across study results. Aim To conduct a met…
View article: Pharmacological treatment for children with constipation: present and future
Pharmacological treatment for children with constipation: present and future Open
View article: Delayed Gastric Emptying Correlates With Decreased Post-prandial Motility in Children: A Single-center Retrospective Review
Delayed Gastric Emptying Correlates With Decreased Post-prandial Motility in Children: A Single-center Retrospective Review Open
ADM findings differ between children with DGE and NGE. Children with DGE are more likely to have abnormal fasting phase III patterns and decreased post-prandial antral activity during ADM testing.
View article: Comparison of colonoscopic versus fluoroscopic colonic manometry catheter placement in children
Comparison of colonoscopic versus fluoroscopic colonic manometry catheter placement in children Open
Objectives Colonic manometry catheter placement can be performed by colonoscopy or fluoroscopy. Our objective was to compare outcomes of colonoscopic to fluoroscopic catheter placement in children based on the extent of colon study and the…
View article: Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility
Pediatric to adult transition care in neurogastroenterology and motility: A position paper from the American Neurogastroenterology and Motility Society and European Society of Neurogastroenterology and Motility Open
Transition services—programs that support adolescents and young adults (AYAs) as they move from a child‐centered to a more autonomous, adult‐orientated healthcare system—have been associated with improved short‐ and long‐term healthcare ou…
View article: Executing and facilitating the successful combined multichannel intraluminal impedance and pH monitoring study
Executing and facilitating the successful combined multichannel intraluminal impedance and pH monitoring study Open
Successful multichannel intraluminal impedance and pH monitoring (MII-pHM) studies rely on constant attendants (CAs) or family members (and sometimes the patients themselves) to assist in the execution and facilitation of the MII-pHM study…
View article: The Effects of High-Intensity Interval Training on Cognitive and Physical Skills in Basketball and Soccer Players
The Effects of High-Intensity Interval Training on Cognitive and Physical Skills in Basketball and Soccer Players Open
As athletes pursue excellence, training techniques continue to advance, making structured physical activity an essential tool for enhancing performance. To optimize athletic performance in modern competitive sports, the balance of physical…
View article: Current practice in the care of children with functional constipation: What is the hold up?
Current practice in the care of children with functional constipation: What is the hold up? Open
Objectives For children with intractable functional constipation (FC), there are no evidence‐based guidelines for subsequent evaluation and treatment. Our objective was to assess the practice patterns of a large, international cohort of pe…
View article: How do we define therapy-resistant constipation in children aged 4–18 years old? A systematic review with meta-narrative synthesis
How do we define therapy-resistant constipation in children aged 4–18 years old? A systematic review with meta-narrative synthesis Open
Background Therapy-resistant constipation often is a frustrating clinical entity recognised by the persistence of infrequent and painful bowel movements faecal incontinence and abdominal pain despite intensive treatment. It is important to…
View article: Ambulatory Impedance-pH Assessment Is the Industry Standard But Is It Always the Best Choice?
Ambulatory Impedance-pH Assessment Is the Industry Standard But Is It Always the Best Choice? Open
View article: Genetic and acquired sucrase‐isomaltase deficiency: A clinical review
Genetic and acquired sucrase‐isomaltase deficiency: A clinical review Open
Genetic sucrase‐isomaltase deficiency (GSID) is an inherited deficiency in the ability to digest sucrose and potentially starch due to mutations in the sucrase‐isomaltase ( SI ) gene. Congenital sucrase‐isomaltase deficiency is historicall…
View article: ESPGHAN and NASPGHAN 2023 protocol for paediatric FAPD treatment guidelines (standard operating procedure)
ESPGHAN and NASPGHAN 2023 protocol for paediatric FAPD treatment guidelines (standard operating procedure) Open
Introduction To date, no international guidelines have been published for the treatment of paediatric functional abdominal pain disorders (FAPDs), subcategorised into functional abdominal pain–not otherwise specified (FAP-NOS), irritable b…
View article: Multi-disciplinary Insights from the First European Forum on Visceral Myopathy 2022 Meeting
Multi-disciplinary Insights from the First European Forum on Visceral Myopathy 2022 Meeting Open
View article: First study to assess the reliability of commonly used pain scales in children with disorders of gut‐brain interaction
First study to assess the reliability of commonly used pain scales in children with disorders of gut‐brain interaction Open
Background There are no validated measures to assess chronic abdominal pain (AP) in clinical trials of children with disorders of gut–brain interaction (DGBIs). Currently used AP measures are extrapolated from studies on adults or children…
View article: Long‐Term Outcomes of Antegrade Continence Enemas to Treat Constipation and Fecal Incontinence in Children
Long‐Term Outcomes of Antegrade Continence Enemas to Treat Constipation and Fecal Incontinence in Children Open
Objectives: The objective of this study is to investigate long‐term outcomes of antegrade continence enema (ACE) treatment in children with constipation or fecal incontinence. Methods: Prospective cohort study including pediatric patients …
View article: Accuracy of Anorectal Manometry to Detect the Rectoanal Inhibitory Reflex in Children
Accuracy of Anorectal Manometry to Detect the Rectoanal Inhibitory Reflex in Children Open
Objectives: Our objective was to investigate if there is a difference in the detection of the rectoanal inhibitory reflex (RAIR) when an anorectal manometry (ARM) is performed awake or under general anesthesia. Methods: A retrospective rev…
View article: Autosomal Recessive ACTG2‐Related Visceral Myopathy in Brothers
Autosomal Recessive ACTG2‐Related Visceral Myopathy in Brothers Open
Objectives: Pediatric intestinal pseudo‐obstruction (PIPO) is a heterogeneous condition characterized by impaired gastrointestinal propulsion, a broad clinical spectrum, and variable severity. Several molecular bases underlying primary PIP…
View article: Significant Temporal Association of Esophageal Air Events (Supragastric Belches, Air Swallows, and Gastric Belches) With Hiccups
Significant Temporal Association of Esophageal Air Events (Supragastric Belches, Air Swallows, and Gastric Belches) With Hiccups Open
We previously reported our ability to objectively assess the strength of temporal relationships between gastroesophageal reflux (GER) disease‐like symptoms with esophageal air events (EAEs) (air swallows, gastric belching, and supragastric…
View article: Do we need an extra dimension? A pilot study on the use of three‐dimensional anorectal manometry in children with functional constipation
Do we need an extra dimension? A pilot study on the use of three‐dimensional anorectal manometry in children with functional constipation Open
Background Recently, a new high‐definition (or three‐dimensional “3D”) high‐resolution anorectal manometry (3D‐ARM) catheter has been introduced. This catheter allows for a more detailed visualization of the anal canal. However, its clinic…
View article: Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial
Hypnosis to Reduce Distress in Children Undergoing Anorectal Manometry: A Randomized Controlled Pilot Trial Open
A brief session of hypnosis for children before ARM is an easily incorporable intervention that lowers distress levels prior to the procedure and is positively perceived by children and parents.
View article: Functional Nausea Is Real and Makes You Sick
Functional Nausea Is Real and Makes You Sick Open
Functional nausea is a condition that severely impairs the quality of life of affected individuals. Only recently, it has been added to the pediatric list of disorders of gut-brain interaction. In most cases, only minimal testing is needed…
View article: International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature
International Consensus Recommendations for Eosinophilic Gastrointestinal Disease Nomenclature Open
View article: Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome
Effect of Open-label Placebo on Children and Adolescents With Functional Abdominal Pain or Irritable Bowel Syndrome Open
ClinicalTrials.gov Identifier: NCT02389998.
View article: The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review
The Use of Linaclotide in Children with Functional Constipation or Irritable Bowel Syndrome: A Retrospective Chart Review Open
Nearly half of children with FC or IBS-C benefited from linaclotide, but adverse events were relatively common. Further prospective, controlled studies are needed to confirm these findings and to identify which patients are most likely to …
View article: Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension
Lubiprostone for Pediatric Functional Constipation: Randomized, Controlled, Double-Blind Study With Long-term Extension Open
Lubiprostone did not demonstrate statistically significant effectiveness over placebo in children and adolescents with PFC but did demonstrate a safety profile similar to that in adults. (ClinicalTrials.gov: Number: NCT02042183; Number: NC…
View article: Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study
Simultaneous assessment of colon motility in children with functional constipation by cine-MRI and colonic manometry: a feasibility study Open