Yuan‐Di Zhao
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View article: Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy
Engineered Bacterial Outer Membrane Vesicles Hitchhiking on Neutrophils for Antibody Drug Delivery to Enhance Postoperative Immune Checkpoint Therapy Open
In clinical practice, surgical removal of tumors often leaves behind small tumors and circulating tumor cells, increasing the risk of metastasis and recurrence, which seriously affects treatment outcomes. Immunotherapy activates the immune…
View article: Programmable engineered bacteria as sustained-releasing antibody factory in situ for enhancing tumor immune checkpoint therapy
Programmable engineered bacteria as sustained-releasing antibody factory in situ for enhancing tumor immune checkpoint therapy Open
Tumor immune checkpoint therapy (ICT) aims to block immune escape signals between tumor and immune cells. However, low delivery efficiency of immune checkpoint inhibitors (ICIs), narrow single-target approach, and reduced responsiveness no…
View article: Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation
Staudinger Reaction-Responsive Coacervates for Cytosolic Antibody Delivery and TRIM21-Mediated Protein Degradation Open
A low-molecular-weight compound whose structure strikes a fine balance between hydrophobicity and hydrophilicity may form coacervates via liquid-liquid phase separation in an aqueous solution. These coacervates may encapsulate and convoy p…
View article: Open set label noise learning with robust sample selection and margin-guided module
Open set label noise learning with robust sample selection and margin-guided module Open
In recent years, the remarkable success of deep neural networks (DNNs) in computer vision is largely due to large-scale, high-quality labeled datasets. Training directly on real-world datasets with label noise may result in overfitting. Th…
View article: Phase‐Separated Spiropyran Coacervates as Dual‐Wavelength‐Switchable Reactive Oxygen Generators
Phase‐Separated Spiropyran Coacervates as Dual‐Wavelength‐Switchable Reactive Oxygen Generators Open
Low‐molecular‐weight compounds of certain structural features may form coacervates through liquid‐liquid phase separation (LLPS). These coacervates can enter mammalian cells and affect cellular physiology. Controlling the properties of the…
View article: Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy
Regulating copper homeostasis of tumor cells to promote cuproptosis for enhancing breast cancer immunotherapy Open
Cuproptosis is an emerging mode of programmed cell death for tumor suppression but sometimes gets resisted by tumor cells resist under specific mechanisms. Inhibiting copper transporter ATPase (ATP7A) was found to disrupt copper ion homeos…
View article: Advancing ultimate bond stress–slip model of UHPC structures through a novel hybrid machine learning approach
Advancing ultimate bond stress–slip model of UHPC structures through a novel hybrid machine learning approach Open
View article: Research on the Multiple Capacitor Current Sharing of High-Current Receiving Coils in a Series–Series Wireless Charging System
Research on the Multiple Capacitor Current Sharing of High-Current Receiving Coils in a Series–Series Wireless Charging System Open
In order to improve wireless charging power and reduce heating problems, the optimal design of the high-current wireless charging coil has always been the research focus of wireless charging system research. This paper proposes a multi-bra…
View article: Recent progress of nano-drugs in neutron capture therapy
Recent progress of nano-drugs in neutron capture therapy Open
As a developing radiation treatment for tumors, neutron capture therapy (NCT) has less side effects and a higher efficacy than conventional radiation therapy. Drugs with specific isotopes are indispensable counterparts of NCT, as they are …
View article: Ultrasmall Bi/Cu Coordination Polymer Combined with Glucose Oxidase for Tumor Enhanced Chemodynamic Therapy by Starvation and Photothermal Treatment
Ultrasmall Bi/Cu Coordination Polymer Combined with Glucose Oxidase for Tumor Enhanced Chemodynamic Therapy by Starvation and Photothermal Treatment Open
Multi‐modal combination therapy for tumor is expected to have superior therapeutic effect compared with monotherapy. In this study, a super‐small bismuth/copper‐gallic acid coordination polymer nanoparticle (BCN) protected by polyvinylpyrr…
View article: Recognition of Rare Microfossils Using Transfer Learning and Deep Residual Networks
Recognition of Rare Microfossils Using Transfer Learning and Deep Residual Networks Open
Various microfossils from the early Cambrian provide crucial clues for understanding the Cambrian explosion and the origin of animal phyla. However, specimens with important anatomical structures are extremely rare and the efficiency of re…
View article: State-of-the-Art Fluorescent Probes: Duplex-Specific Nuclease-Based Strategies for Early Disease Diagnostics
State-of-the-Art Fluorescent Probes: Duplex-Specific Nuclease-Based Strategies for Early Disease Diagnostics Open
Precision healthcare aims to improve patient health by integrating prevention measures with early disease detection for prompt treatments. For the delivery of preventive healthcare, cutting-edge diagnostics that enable early disease detect…
View article: A self-assembled bilayer polypeptide-engineered hydrogel for spatiotemporal modulation of bactericidal and anti-inflammation process in osteomyelitis treatment
A self-assembled bilayer polypeptide-engineered hydrogel for spatiotemporal modulation of bactericidal and anti-inflammation process in osteomyelitis treatment Open
View article: Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia
Biomimetic material degradation for synergistic enhanced therapy by regulating endogenous energy metabolism imaging under hypothermia Open
Inefficient tumour treatment approaches often cause fatal tumour metastases. Here, we report a biomimetic multifunctional nanoplatform explicitly engineered with a Co-based metal organic framework polydopamine heterostructure (MOF-PDA), an…
View article: Application of multifunctional nanoprobes in tumor immunotherapy guided by medical imaging
Application of multifunctional nanoprobes in tumor immunotherapy guided by medical imaging Open
Immunotherapy has attracted extensive attention as an effective means for tumor treatment instead of traditional methods such as surgery, radiotherapy, and chemotherapy. The combination of immunotherapy and multifunctional nanoprobes can r…
View article: Recent advances in ionic current rectification based nanopore sensing: a mini-review
Recent advances in ionic current rectification based nanopore sensing: a mini-review Open
In recent years, the intensive studies have been devoted to nanopores due to their unique charge transport properties including ion permselectivity, ion concentration polarization, and ionic current rectification (ICR). Based on ICR, the a…
View article: Red blood cell membrane-enveloped O<sub>2</sub> self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy
Red blood cell membrane-enveloped O<sub>2</sub> self-supplementing biomimetic nanoparticles for tumor imaging-guided enhanced sonodynamic therapy Open
Non-invasive sonodynamic therapy (SDT) was developed because of its advantages of high penetration depth and low side effects; however, tumor hypoxia greatly restricts its therapeutic effect. In this study, we aimed to develop ideal O…
View article: Hollow gold nanoshells-incorporated injectable genetically engineered hydrogel for sustained chemo-photothermal therapy of tumor
Hollow gold nanoshells-incorporated injectable genetically engineered hydrogel for sustained chemo-photothermal therapy of tumor Open
Background Combined therapy has demonstrated to be an effective strategy for cancer therapy. Herein, an injectable hydrogel based on the genetically engineered polypeptide and hollow gold nanoshells (HAuNS) has been developed for chemo-pho…
View article: Detection of alkaline phosphatase activity with a functionalized nanopipette
Detection of alkaline phosphatase activity with a functionalized nanopipette Open
In this study, a label-free sensing method based on a functionalized nanopipette is proposed for detection of alkaline phosphatase (ALP) activity. This method is based on the unique charge transport properties of nanopores in which the ion…
View article: Intelligent gold nanostars for <i>in vivo</i> CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy
Intelligent gold nanostars for <i>in vivo</i> CT imaging and catalase-enhanced synergistic photodynamic & photothermal tumor therapy Open
Photodynamic therapy (PDT) is a clinically approved and minimally invasive form of cancer treatment. However, due to hypoxia at the tumor site and phototoxicity to normal tissues, monotherapies using photosensitizers remain suboptimal. Thi…
View article: A near-infrared light-controlled smart nanocarrier with reversible polypeptide-engineered valve for targeted fluorescence-photoacoustic bimodal imaging-guided chemo-photothermal therapy
A near-infrared light-controlled smart nanocarrier with reversible polypeptide-engineered valve for targeted fluorescence-photoacoustic bimodal imaging-guided chemo-photothermal therapy Open
Despite burgeoning development of nanoplatform made in the past few years, it remains a challenge to produce drug nanocarrier that enables requested on/off drug release. Thus, this study aimed to develop an ideal near-infrared light-trigge…
View article: Tumor Margin Demarcation and Therapy: A NanoFlare‐Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy (Small 50/2018)
Tumor Margin Demarcation and Therapy: A NanoFlare‐Based Strategy for In Situ Tumor Margin Demarcation and Neoadjuvant Gene/Photothermal Therapy (Small 50/2018) Open
In article number 1802745, Yong-Qiang Li and co-workers report a robust tumor microenvironment-responsive theranostic nanoprobe (NanoFlare). By virtue of its anisotropic oligonucleotides-spike nanostructure, the NanoFlare can enter tumor c…
View article: pH-modulated ion-current rectification in a cysteine-functionalized glass nanopipette
pH-modulated ion-current rectification in a cysteine-functionalized glass nanopipette Open
The unique properties of nanopores depend largely on the functionalization of the pore surface, which has always been a great challenge. In this study, a facile method for functionalizing the surface of a glass nanopipette to establish thi…
View article: A multifunctional targeting probe with dual-mode imaging and photothermal therapy used in vivo
A multifunctional targeting probe with dual-mode imaging and photothermal therapy used in vivo Open
View article: <i>In vivo</i> Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy
<i>In vivo</i> Imaging-Guided Nanoplatform for Tumor Targeting Delivery and Combined Chemo-, Gene- and Photothermal Therapy Open
Currently, a large number of anti-tumor drug delivery systems have been widely used in cancer therapy. However, due to the molecular complexity and multidrug resistance of tumors, monotherapies remain suboptimal. Thus, this study aimed to …
View article: Recent advancements of high efficient donor–acceptor type blue small molecule applied for OLEDs
Recent advancements of high efficient donor–acceptor type blue small molecule applied for OLEDs Open
Although the organic light-emitting devices (OLEDs) encompassing TVs, smartphones, and wearable devices, etc. already have been commercialized, there is still room to pursue material improvements in efficiency and cost-effectiveness. Organ…
View article: Preparation, Modification, and Application of Hollow Gold Nanospheres
Preparation, Modification, and Application of Hollow Gold Nanospheres Open
Hollow gold nanospheres (HGNs) have great potential applications in biological sensing, biomedical imaging, photothermal therapy, and drug delivery due to their unique localized surface plasmon resonance (LSPR) feature, easy modification, …