Diana Aguilar‐León
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View article: Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement to LAIR-1 in Circulating Monocytes, Avoiding Long COVID
Polymerized Type I Collagen Downregulates STAT-1 Phosphorylation Through Engagement to LAIR-1 in Circulating Monocytes, Avoiding Long COVID Open
The intramuscular administration of polymerized type I collagen (PTIC) for adult symptomatic COVID-19 outpatient downregulated hyperinflammation and improved symptoms. We inferred that LAIR-1 is a potential receptor for PTIC. Thus, binding…
View article: Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease
Participation of Semaphorin Family and Plexins in the Clinical Course of Patients with Inflammatory Bowel Disease Open
Semaphorins are an immunoregulatory protein family. Plexins bind semaphorins (SEMAs) and can form receptor complexes that give them chemotactic capacity. The role and expression profile of semaphorins and plexins in inflammatory bowel dise…
View article: A Higher Manometric Esophageal Length to Height Ratio in Achalasia Explains the Lower Prevalence of Hiatal Hernia
A Higher Manometric Esophageal Length to Height Ratio in Achalasia Explains the Lower Prevalence of Hiatal Hernia Open
The prevalence of HH in achalasia is significantly lower than in GERD. The longer EL and the higher MELH ratio in achalasia could explain the lower prevalence of HH. Despite the low prevalence of HH in achalasia patients, the surgeon shoul…
View article: Polymerized type I collagen down-regulates STAT-1 phosphorylation through engagement to LAIR-1 in M1-macrophages avoiding long COVID
Polymerized type I collagen down-regulates STAT-1 phosphorylation through engagement to LAIR-1 in M1-macrophages avoiding long COVID Open
Background The polymerized type I collagen (PTIC) is a γ-irradiated mixture of pepsinized porcine type I collagen and polyvinylpyrrolidone (PVP). It has immunomodulatory properties. However, the receptor and signaling pathway through which…
View article: Is the Sars‐CoV‐2 virus a possible trigger agent for the development of achalasia?
Is the Sars‐CoV‐2 virus a possible trigger agent for the development of achalasia? Open
Background Achalasia is an autoimmune disease whose probable causal agent is a neurotropic virus that chronically infects the myenteric plexus of the esophagus and induces the disease in a genetically susceptible host. The association betw…
View article: Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia?
Is the Sars-CoV-2 virus a possible trigger agent for the development of achalasia? Open
BACKGROUND Previous studies have suggested that achalasia is an autoimmune disease whose probable causal agent is a neurotropic virus that chronically infects the myenteric plexus of the esophagus and, in a genetically susceptible host, in…
View article: Exposing the Great Imitator: Proposal for a Holistic Diagnosis of Oral Secondary Syphilis in People Living with HIV
Exposing the Great Imitator: Proposal for a Holistic Diagnosis of Oral Secondary Syphilis in People Living with HIV Open
View article: An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation
An enriched environment re-establishes metabolic homeostasis by reducing obesity-induced inflammation Open
Obesity can lead to chronic inflammation in different tissues, generating insulin and leptin resistance and alterations in glucose and lipid metabolism, favoring the development of degenerative diseases, including type II diabetes. Congrue…
View article: Autoantigen characterization in the lower esophageal sphincter muscle of patients with achalasia
Autoantigen characterization in the lower esophageal sphincter muscle of patients with achalasia Open
OBJECTIVE To characterize in sera anti-myenteric autoantibody profiles and in tissues MMP-9 proteoforms towards the identification of possible autoantigenic proteins in the muscle of the lower esophageal sphincter (LES) of achalasia patien…
View article: Clinical features of patients with Rocky Mountain spotted fever, dengue and chikungunya infection
Clinical features of patients with Rocky Mountain spotted fever, dengue and chikungunya infection Open
Rash on the palms and soles, edema and absence of pruritus, together with high levels of direct bilirubin and severe thrombocytopenia could be useful indicators to differentiate patients at RMSF advanced stages from those with dengue and c…
View article: Autoantigen Characterization in the Lower Esophageal Sphincter Muscle of Patients with Achalasia
Autoantigen Characterization in the Lower Esophageal Sphincter Muscle of Patients with Achalasia Open
View article: Infectious agents as potential triggers for autoimmunity in achalasia
Infectious agents as potential triggers for autoimmunity in achalasia Open
View article: AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease
AT1 receptor antagonism before ischemia prevents the transition of acute kidney injury to chronic kidney disease Open
View article: Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study
Achalasia—An Autoimmune Inflammatory Disease: A Cross-Sectional Study Open
Idiopathic achalasia is a disease of unknown etiology. The loss of myenteric plexus associated with inflammatory infiltrates and autoantibodies support the hypothesis of an autoimmune mechanism. Thirty-two patients diagnosed by high-resolu…